Ramelteon Yepakati 12 CAS 1053239-39-6 Kuchena > 98.0% (HPLC)
Kutungamira Mugadziri uye Mutengesi, Pakati peRamelteon
Ramelteon (TAK-375) CAS 196597-26-9
2,3-Dihydrobenzofuran CAS 496-16-2
1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-imwe CAS 196597-78-1
Ramelteon Acrylonitrile CAS 196597-79-2
Despropionyl Ramelteon Hydrochloride CAS 196597-80-5
2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride CAS 1053239-39-6
Please contact: alvin@ruifuchem.com
| Chemical Name | 2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride |
| Mashoko anoreva zvakafanana | Ramelteon Pakati 12;Ramelteon Stage-2 Kusachena;1,6,7,8-Tetrahydro-2H-Indeno[5,4-B]Furan-8-Ethanamine Hydrochloride |
| Nhamba yeCAS | 1053239-39-6 |
| Nhamba yeCAT | RF2887 |
| Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Matani |
| Molecular Formula | C13H18ClNO |
| Molecular Weight | 239.74 |
| Melting Point | 165.0~167.0℃ |
| Density | 1.058±0.06 g/cm3 |
| Brand | Ruifu Chemical |
| Item | Zvinotsanangurwa |
| Chitarisiko | Ichena kusvika Kuchena-Ichena Solid Powder |
| Kuchena / Analysis Method | >98.0% (HPLC) |
| Kurasika paKuomesa | <1.00% |
| Kusachena Kumwechete | <1.00% |
| Zvose Zvisina Kuchena | <2.00% |
| 1 H NMR Spectrum | Zvinoenderana Nechimiro |
| Test Standard | Enterprise Standard |
| Usage | Pakati peRamelteon (CAS: 196597-26-9) |
Package: Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza uye unyoro
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride (CAS: 1053239-39-6) iri pakati peRamelteon (CAS: 196597- 26-9).Kusiyana nemishonga yakawanda yekushaya hope inotarisa GABA (g-aminobutyric acid) receptor complex, Ramelteon inyanzvi ye melatonin receptor.Kunyanya, ine high selectivity yeMT1 uye MT2 subtypes, iyo yakave yakabatanidzwa mukuchengetedza circadian rhythms, pamusoro peMT3 receptor inotarisira mamwe mabasa emelatonin.Kushaikwa kwayo kwehukama kwete chete GABA receptor complex asiwo neurotransmitter, dopaminerigic, opiate, uye benzodiazepine receptors inoratidza yakagadziridzwa chengetedzo chimiro chisina kushungurudzwa kunogona kuitika kwemishonga yehypnotic inotarisa aya mareceptor.Sezvo zvakadaro, Ramelteon haisi mushonga wakarongwa.Primary metabolites inosanganisira hydroxylation uye oxidation kune carbonyl marudzi ane yechipiri metabolites inokonzerwa neglucuronidation.Sezvo CYP1A2 ndiyo isozyme huru inobatanidzwa muhepatic metabolism yeRamelteon, haifaniri kutorwa pamwe chete neCYP1A2 inhibitors yakasimba, yakadai se fluvoxamine.Kubata pamwe chete neketoconazole (a CYP3A4 inhibitor) kana fluconazole (ine simba CYP2C9 inhibitor) yakaguma nekuwedzera kukuru kweAUC neCmax, asi iyo yakawanda yemasabolism uye yakawanda yakasiyana-siyana yeplasma yeRamelteon yakadzivisa kudiwa kwekushandurwa kwedhesi.Iyo pasuru yekuisa, zvisinei, inonyevera varwere nezve co-kutonga neine simba CYP3A4 uye CYP2C9 inhibitors.Zvichienderana nemhedzisiro yemakiriniki ekuyedzwa, iyo yakakurudzirwa dhizaini yeRamelteon ndeye 8mg inotorwa mukati me30 min yekuenda kunorara.Mukuwedzera kune kuchenjerera kwekubatana pamwe neCYP inhibitors, haifaniri kushandiswa kune varwere vane chirwere chakanyanya chehepatic.Zviitiko zvakashata, zvakaonekwa mu5% yevarwere muzvidzidzo zvekiriniki, vaive vasina kurara, dzungu, kuda kurutsa, kuneta, kutemwa nemusoro, uye kushaya hope.
