Remdesivir GS-5734 CAS 1809249-37-3 COVID-19 API Yemhando yepamusoro
Mugadziri Wekutengesa Kwekutengesa Remdesivir uye Vanoenderana Vanopindirana vane Hunhu Hwepamusoro
Remdesivir CAS 1809249-37-3
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Chemical Name | Remdesivir |
Mashoko anoreva zvakafanana | GS-5734;2-ethylbutyl ((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano -3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate |
Nhamba yeCAS | 1809249-37-3 |
Nhamba yeCAT | RF-API96 |
Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Mazana emaKilogram |
Molecular Formula | C27H35N6O8P |
Molecular Weight | 602.58 |
Density | 1.47±0.1 g/cm3 |
Brand | Ruifu Chemical |
Item | Zvinotsanangurwa |
Chitarisiko | Ichena kusvika Kuchena-Ichena Solid Powder |
Identification A | IR: Iyo infrared absorption spectrum yechigadzirwa inofanira kuenderana neiyo yezvinhu zvinorehwa. |
Kuzivikanwa B | HPLC Kuchengeta nguva yakafanana nereferenzi chinhu |
Specific Rotation | -19.0° ~ -22.0° |
Solubility | Solunle muMethanol, Inonyungudika Zvishoma muEthanol, Inonyungudika zvishoma muAcetonitrile, Isinganyungudike mumvura |
Related Substances | |
Chero Kusachena Kwemunhu | ≤0.10% |
Zvose Zvisina Kuchena | ≤1.0% |
RD-3.1 | ≤0.10% |
RD-C | ≤0.10% |
RD-D | ≤0.10% |
RD-E | ≤0.10% |
RP-Isomer | ≤0.10% |
Nitrophenol | ≤0.10% |
Residual Solvents | |
Methanol Dichloride | ≤6000ppm |
Acetone | ≤5000ppm |
Isopropyl Doro | ≤5000ppm |
Acetonitrile | ≤410ppm |
Dichloromethane | ≤600ppm |
Methyl tert Butyl Ether | ≤5000ppm |
Ethyl Acetate | ≤5000ppm |
Tetrahydrofuran | ≤720ppm |
n-Heptane | ≤5000ppm |
Assay | 98.0% ~ 102.0% (Yakaverengerwa pane yakaomeswa hwaro) |
Total Aerobic Counts | |
Aerobic Bacteria | ≤100cfu/g |
Mbiriso uye Mold | ≤10cfu/g |
E. Coil | Negative |
Bacterial Endotoxin | ≤1.0EU |
Heavy Metals | ≤20ppm |
Test Standard | Enterprise Standard |
Usage | API, COVID-19 |
Package: Bhodhoro, Aluminium foil bag, Cardboard dhiramu, 25kg/Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza, mwando uye tumbuyu.
Remdesivir (CAS 1809249-37-3), inotengeswa pasi pezita rezita reVeklury, mushonga unorwisa utachiona wakagadzirwa nekambani yebiopharmaceutical yeGiriyedhi Sayenzi.Inoitwa kuburikidza nejekiseni mutsinga.Munguva yeCOVID-19 denda, remdesivir yakatenderwa kana kupihwa mvumo yekushandiswa kwekukurumidzira kurapa COVID-19 munyika dzinosvika makumi mashanu.Nhungamiro dzakagadziridzwa kubva kuWorld Health Organisation muna Mbudzi 2020 dzinosanganisira kurudziro yekupokana nekushandiswa kweRemdesivir kurapwa kweCOVID-19.Remdesivir yakatanga kugadzirwa kurapa hepatitis C, uye yakazoferefetwa nezvechirwere cheEbola virus uye Marburg virus utachiona isati yadzidzwa semushonga wekubatira hutachiona hweCOVID-19.Izvo zvinowanzoitika kune vanozvipira vane hutano zvinosimudza mazinga eropa echiropa enzymes (chiratidzo chezvinetso zvechiropa).Iyo inonyanya kukonzeresa muvanhu vane COVID-19 kusvotwa.Mhedzisiro inogona kusanganisira kuzvimba kwechiropa uye kuita kwakabatana-nekupinda nekusvotwa, kuderera kweropa, uye dikita.Remdesivir iprodrug inoitirwa kubvumira intracellular kuendeswa kweGS-441524 monophosphate uye inotevera biotransformation muGS-441524 triphosphate, ribonucleotide analogue inhibitor yeviral RNA polymerase.