Sitagliptin Phosphate Monohydrate CAS 654671-77-9 Kuchena > 99.0% (HPLC) API Factory High Quality

Tsanangudzo Pfupi

Zita reKemikari: Sitagliptin Phosphate Monohydrate

CAS: 654671-77-9

Kuchena:> 99.0% (HPLC pane yakaomeswa nheyo)

Chitarisiko: Ichena kusvika Kure-Ichena Crystalline Powder

Kurapa kwechirwere cheshuga mellitus chechipiri

API High Quality, Commercial Production

E-Mail: alvin@ruifuchem.com

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Tsanangudzo:

Supply Sitagliptin Phosphate Monohydrate Related Intermediates:
Sitagliptin API CAS 486460-32-6
Purogiramu inonzi Sitagliptin Phosphate Monohydrate CAS 654671-77-9
2,4,5-Trifluorophenylacetic Acid CAS 209995-38-0
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid CAS 486460-00-8
Sitagliptin Triazole Hydrochloride CAS 762240-92-6
Sitagliptin Phosphate Monohydrate Yepakati CAS 486460-21-3

Chemical Properties:

Chemical Name	Sitagliptin Phosphate Monohydrate
Mashoko anoreva zvakafanana	(R) -3-amino-1-(3-(trifluoromethyl) -5,6-dihydro--[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4- (2,4,5-trifluorophenyl)butan-1-one phosphate monohydrate
Nhamba yeCAS	654671-77-9
Stock Status	MuStock, Kugadzirwa Kunokwira Kusvika Matani
Molecular Formula	C16H20F6N5O6P
Molecular Weight	523.3240802
Melting Point	202.0~204.0℃
Mvura Solubility	Soluble mumvura
Specific Rotation	-18.0°~-23.0° (C=1, Mvura)
Brand	Ruifu Chemical

Zvinotsanangurwa:

Item	Zvinotsanangurwa
Chitarisiko	Ichena kusvika kuOff-White Crystalline Powder
Kuzivikanwa neHPLC	Nguva yekuchengetedza yemuenzaniso inopindirana nereferensi standard
IR-Infrared Spectrum	Iyo IR Absorption Spectrum yemuenzaniso ichaenderana neiyo yeyakajairwa spectrum
Phosphate	Zvinoenderana
Kuchena / Analysis Method	> 99.0% (HPLC pane yakaomeswa nheyo)
Zvemumvura (KF)	3.3%~4.4%
Residue paIgnition	≤0.20%
Sulfate	≤0.02%
Chloride	≤0.05%
Chiral Kusachena	<0.50%
Related Substances
Kusachena Kumwechete	<0.50%
Zvose Zvisina Kuchena	<1.0%
Ethyl Acetate	<0.50%
Heavy Metals	<20ppm
Test Standard	Enterprise Standard
Usage	Pharmaceutical Intermediates

Package & Kuchengeta:

Package: Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.

Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza uye unyoro.

Zvakanakira:

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Application:

Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9), mushonga mutsva wekurapa chirwere cheshuga chechipiri.Muna Nyamavhuvhu 2009, mushonga uyu wakabvumidzwa neEuropean Union semushonga wekutanga wekurapa chirwere cheshuga cherudzi rwechipiri.Sitagliptin Phosphate ndiyo yekutanga FDA-yakatenderwa dipeptidyl peptidase-IV inhibitor kushandiswa mukurapa rudzi rwechipiri chirwere cheshuga kusvika kure, pasi pezita rekutengesa Januvia.Dipeptidylpeptidase Ⅳ (DPP-Ⅳ) inokurumidza uye zvinobudirira kuderedza GLP-1, GLP-1, inova inonyanya kusimudzira yekugadzirwa kwe insulin uye secretion Naizvozvo, inhibition yeDPP-IV inogona kuwedzera basa reendogenous GLP-1, nekudaro kuwedzera ropa. insulin mazinga, nekudaro kuderedza nekuchengetedza mazinga eglucose eropa muvarwere vane chirwere cheshuga.Parizvino, mishonga yakasimbisa kuti DPP-IV inhibitor rudzi rutsva rwemishonga inorwisa chirwere cheshuga, uye migumisiro yekliniki inoratidza kuti mishonga ine yakanaka hypoglycemic effect.Nekuda kwekuti GLP-1 inotora basa rinoenderana neshuga mukusimudzira kugadzirwa kwe insulin uye kugadzirwa kwe insulin, zvinowanzoitika zvakashata senge hypoglycemia uye kuwanda kwehuremu kunokonzerwa nekushandiswa kwemishonga inorwisa chirwere cheshuga hazviitike.