Sorafenib Tosylate CAS 475207-59-1 Purity ≥99.0% (HPLC) API Factory High Quality
Commerce Supply Sorafenib Tosylate uye Related Intermediates:
Sorafenib Tosylate CAS: 475207-59-1
Sorafenib CAS: 284461-73-0
4-Chloro-N-Methyl-2-Pyridinecarboxamide CAS: 220000-87-3
4-(4-Aminophenoxy)-N-Methylpicolinamide CAS: 284462-37-9
4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate CAS: 327-78-6
| Chemical Name | Sorafenib Tosylate |
| Mashoko anoreva zvakafanana | Nexavar;4--[4-[3--[4-Chloro-3-(Trifluoromethyl)phenyl]ureido]phenoxy]-N-Methylpicolinamide 4-Methylbenzenesulfonate;4- [[4-Chloro-3-(Trifluoromethyl)phenyl]carbamamido]phenoxy]-N-Methyl-2-Pyridinecarboxamide 4-Methylbenzenesulfonate;BAY 43-9006 Tosylate |
| Nhamba yeCAS | 475207-59-1 |
| Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Mazana emaKilogram |
| Molecular Formula | C21H16ClF3N4O3.C7H8O3S |
| Molecular Weight | 637.03 |
| Melting Point | 225.0 kusvika 230.0 ℃ |
| Sensitive | Mhepo Inonzwa, Inonzwa Kupisa |
| Solubility | Soluble muMvura (<1 mg/ml) pa25℃, DMSO (127 mg/ml) pa25℃, uye Ethanol (<1 mg/ml) pa25℃ |
| Shipping Conditions | Inotonhorera & Yakaoma Nzvimbo (2 ~ 8 ℃), Dzivirira kubva kuChiedza |
| COA & MSDS | Available |
| Sherufu Hupenyu | 2 Makore kana Akachengetwa Zvakanaka |
| Brand | Ruifu Chemical |
| Item | Zvinotsanangurwa | Results |
| Chitarisiko | Yero Yero kana Hupfu Huchena | Zvinoenderana |
| Kuchena / Analysis Method | ≥99.0% (HPLC) | 99.8% |
| Melting Point | 225.0~230.0℃ | Zvinoenderana |
| Heavy Metals | ≤10ppm | <10ppm |
| Kurasika paKuomesa | ≤0.50% | 0.12% |
| Residue paIgnition | ≤0.20% | 0.10% |
| Chero Kusachena Kumwe | ≤0.50% | Zvinoenderana |
| Zvose Zvisina Kuchena | ≤0.50% | Zvinoenderana |
| NMR Spectrum | Inopindirana neChimiro | Zvinoenderana |
| Test Standard | Enterprise Standard | Zvinoenderana |
| Usage | Sorafenib Tosylate (CAS: 475207-59-1) mukurapa kweRCC & HCC | |
Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumudziyo wakavharwa zvakasimba.Chengetedza munzvimbo inotonhorera, yakaoma (2 ~ 8 ℃) uye ine mhepo yakanaka yekuchengetera kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
Njodzi Makodhi 36/37/38 - Kushungurudza maziso, kufema system uye ganda.
Tsanangudzo Yekuchengetedza S28 - Mushure mekusangana neganda, geza nekukurumidza nesipo yakawanda.
S26 - Kana wasangana nemaziso, simbura nekukasira nemvura yakawanda uye tsvaga mazano ekurapwa.
Sorafenib Tosylate (CAS: 475207-59-1) rudzi rutsva rwe-multi-target antitumor drug, yakagadziridzwa neGerman Bayer Pharmaceuticals, uye yakaratidza kuwedzera antitumor chiitiko mu preclinical mhuka bvunzo.Sorafenib inowanikwa mumapiritsi e200-mg ekutonga nemuromo uye inoshandiswa mukurapa kweRCC neHCC.Sorafenib Tosylate inogona panguva imwe chete kukanganisa bundu masero uye bundu tsinga dzeropa.Iyo ine kaviri antitumor mhedzisiro: inogona kuvharira sero chiratidzo chekufambisa nzira dzakafambiswa neRAF/MEK/ERK kuvharisa zvakananga tumor cell kukura, uku ichivharisa VEGF uye platelet inotorwa kukura zvinhu (PDGF) receptors kudzivirira kuumbwa kwebundu ropa idzva. midziyo, nokudaro zvisina kunanga inhibiting bundu sero kukura.
Sorafenib Tosylate, zita rekutengesa Nexavar, rakatanga kugadzirwa neBayer Pharmaceuticals kuGermany.Sorafenib Tosylate ndeye multi-kinase inhibitor inogona kushandiswa kurapa zvirwere zvakaita segomarara.Muna Zvita 2005, yakatenderwa neUS FDA semushonga wekutanga wekurapa gomarara retsvo.Muna Nyamavhuvhu 2009, yakanyorwa zviri pamutemo muChina nemvumo yeState Food and Drug Administration.
Sorafenib Tosylate inonzi tyrosine kinases (VEGFR uye PDGFR) uye RAF/MEK/ERK cascade inhibitors, ichishanda panguva imwe chete paRaf-1,wtBRAF uye V599EBRAF, ine IC50 ye6 nM, 22 nM uye 38 nM, zvichiteerana.
Sorafenib Tosylate inogona panguva imwe chete inhibisa zvakasiyana-siyana zve kinase zviripo pane sero uye sero pamusoro, kusanganisira RAF kinase, vascular endothelial growth factor receptor-2 (VEGFR-2), vascular endothelial growth factor receptor-3 (VEGFR-3), platelet. -yakagadzirwa kukura factor receptor-β (PDGFR-β), KIT uye FLT-3.Zvinogona kuonekwa kuti sorafenib toluenesulfonate ine maviri anti-tumor madhara.Kune rumwe rutivi, inogona kudzivisa zvakananga bundu kukura nekudzivisa RAF/MEK/ERK nzira yokuratidza;kune rumwe rutivi, inogona kuvharidzira VEGFR uye PDGFR.Uye vhara kuumbwa kwebundu neovascularization, zvisina kunanga inhibit kukura kwebundu masero.Sorafenib Tosylate ndiwo mushonga unoshanda zvakanyanya pakurapa gomarara rechiropa rinofambira mberi nehurongwa hwekutonga, uye ungangoita mushonga mutsva wekurapa chirwere ichi.
Sorafenib Tosylate kamwe-zuva nezuva kutungamira kwemuromo kwemunhu bundu mhuka transplantation modhi yakaratidza huwandu hwakasiyana hwekurwisa tumor, kusanganisira colon cancer, isiri-diki cell carcinoma, kenza yemazamu, melanoma, pancreatic cancer, leukemia uye ovarian cancer uye mouse renal cell carcinoma. modhi, RENCA modhi.
