Tacrolimus FK-506 Fujimycin CAS 104987-11-3 API Factory High Purity
Mugadziri ane Kuchena Kwepamusoro uye Hwakagadzikana Hunhu
Zita reKemikari: Tacrolimus
Synonyms: FK-506;Fujimycin
CAS: 104987-11-3
API, High Quality, Commercial Production
Chemical Name | Tacrolimus |
Mashoko anoreva zvakafanana | FK-506;Fujimycin |
Nhamba yeCAS | 104987-11-3 |
Nhamba yeCAT | RF-API46 |
Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Matani |
Molecular Formula | C44H69NO12 |
Molecular Weight | 804.02 |
Brand | Ruifu Chemical |
Item | Zvinotsanangurwa |
Chitarisiko | Off-White kana Yellow Fine Poda, isinganhuhwi, Special Sweet Taste |
Identification | Inofanira kuva Positive Reaction |
Kujeka | Teerera neChimiro |
pH | 5.0~6.0 |
Chloride | ≤0.014% |
Sulfate | ≤0.029% |
Masimbi anorema (Pb) | ≤10ppm |
Arsenic | ≤0.0002% |
Kunyorova (KF) | ≤8.0% |
Residue paIgnition | 18.0%~22.0% |
Assay | ≥72.0% (HPLC, pane yakaomeswa nheyo) |
Test Standard | Enterprise Standard |
Usage | API |
Package: Bhodhoro, Aluminium foil bag, Cardboard dhiramu, 25kg/Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza, mwando uye tumbuyu.
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Tacrolimus (zvakare FK-506 kana Fujimycin) is immunosuppressive drug iro rinonyanya kushandiswa kuri mushure mekudyarwa kwenhengo kuderedza chiitiko chemurwere immune system uye nekudaro njodzi yekurambwa kwenhengo.Inoshandiswawo mukugadzirwa kwemusoro mukurapa kweatopic dermatitis yakaoma, yakanyanya refractory uveitis mushure mekutapurwa kwemwongo, uye ganda mamiriro vitiligo.Tacrolimus yakatanga kutorwa mumuto wekuvirisa weStreptomyces tsukuba, utachiona hwevhu hunowanikwa muTsukuba, Japan.Zita rekuti tacrolimus rinotorwa nekutora 't' yeTsukuba, zita regomo pakatorwa sampu yevhu, 'acrol' ye macrolide uye 'imus' ye immunosuppressant.Kunyangwe zvimiro zvisina hukama ne cyclosporin, tacrolimus inoratidza yakafanana spectrum ye immunosuppressive mhedzisiro kune uyu mumiririri pamasero uye mamorekuru level.Zvidzidzo zvekutanga zvakaratidza kuti tacrolimus yaive yakasimba immunosuppressant, ichiratidza kanenge ka100-yakakura in vitro potency pane cyclosporin inhibiting T cell activation.Zvidzidzo zvinotevera mu vivo zvakaratidza tacrolimus kuti ishande mukudzvanya zvinongoerekana zvaitika uye kuyedza autoimmune chirwere, uye mukudzivirira alllograft uye kurambwa kwexenograft mumhando dzemhuka dzekuisirwa nhengo.Pakutanga, tacrolimus yaishandiswa kuita systemic immunosuppression yevarwere vakange vaitwa allograft transplants kuti vadzivise kuramba magrafts avo matsva.Nenguva isipi, zvisinei, kuburikidza nerubatsiro rweserendipity yesainzi, zvakaonekwa kuti tacrolimus inogona kuunza mhedzisiro yakanaka mukukanganiswa kweganda mune vamwe varwere vaive vaiswa transplantation.Kuwanikwa kwetacrolimus nekudaro kwakatungamira mukunzwisisa kwakanyanya kweganda pathology, semuenzaniso weatopic dermatitis.Mushure mezvo, kumwe kushandiswa kwepamusoro kwetacrolimus kwakashumwa uye kushandiswa kwemumiririri uyu mudermatology kuri kuwedzera zvishoma nezvishoma.
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