Tolvaptan CAS 150683-30-0 API Kuchena >99.0% (HPLC)
Manufacturer Supply Tolvaptan uye Related Intermediates:
Tolvaptan CAS 150683-30-0
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Zita | Tolvaptan |
Chemical Name | N- [4-(9-chloro-6-hydroxy-2-azabicyclo[5.4.0]undeca-8,10,12-triene-2-carbonyl)-3-methyl-phenyl]-2-methyl-benzamide |
Nhamba yeCAS | 150683-30-0 |
Nhamba yeCAT | RF-API101 |
Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Matani |
Molecular Formula | C26H25ClN2O3 |
Molecular Weight | 448.94 |
Brand | Ruifu Chemical |
Item | Zvinotsanangurwa |
Chitarisiko | Ichena kusvika kuOff-White Crystalline Powder |
Nzira dzekuzivikanwa | IR, HPLC |
Solubility | Soluble muBenzyl Doro uye Methanol asi Isinganyungudike muMvura neHexane |
Kuchena / Analysis Method | >99.0% (HPLC) |
Melting Point | 219.0~222.0℃ |
Kurasika paKuomesa | <0.50% |
Residue paIgnition | <0.10% |
Kusachena Kumwechete | <0.50% |
Zvose Zvisina Kuchena | <1.00% |
Heavy Metals | ≤20ppm |
Residual Solvents | Sangana Nekutsanangurwa |
Test Standard | Enterprise Standard |
Usage | API;Pharmaceutical Intermediates |
Package: Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza uye unyoro
Tolvaptan (CAS: 150683-30-0), inozivikanwawo seOPC-41061, inosarudza, inokwikwidza arginine vasopressin receptor 2 antagonist inoshandiswa kurapa hyponatremia (low blood sodium levels) inobatanidza ne congestive heart failure, cirrhosis, uye syndrome ye isina kukodzera antidiuretic hormone (SIADH).Otsuka Pharmaceutical ine rezinesi tolvaptan pasi pezita rekutengesa Samsca mushure mekunge FDA yabvumidza mushonga uyu muna Chivabvu 2009. Tolvaptan yakaratidzawo kushanda zvakanaka pakurwisa chirwere chepolycystic itsvo.Mukuedza kwe2004, tolvaptan inoshandiswa nemishonga yemagariro yakaonekwa kuti inowedzera kubuda kwemvura yakawandisa uye kuvandudza mazinga e sodium muropa kune varwere vane mwoyo yakakundikana pasina kubudisa migumisiro yakadai se hypotension (low blood pressure) kana hypokalemia (kuderera kweropa re potassium).Mushonga wacho wakaratidzawo kusakanganisa kushanda kweitsvo.