trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7 Purity >98.0% (HPLC) Afatinib Dimaleate Intermediate Featured Image

trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7 Kuchena >98.0% (HPLC) Afatinib Dimaleate Pakati

Tsanangudzo Pfupi:

trans-4-Dimethylaminocrotonic Acid Hydrochloride

CAS: 848133-35-7

Kuchena:> 98.0% (HPLC)

Kuonekwa: Kuchena kusvika Kunenge Hupfu Huchena

Pakati peAfatinib Dimaleate (CAS: 850140-73-7)

Bata: Dr. Alvin Huang

Nharembozha/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Tumira email kwatiri

Product Detail

Product Tags

Tsanangudzo:

Ruifu Chemical Supply Intermediates yeAfatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-imwe CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Chemical Properties:

Chemical Name	trans-4-Dimethylaminocrotonic Acid Hydrochloride
Mashoko anoreva zvakafanana	trans 4-Dimethylaminocrotonic Acid HCl;(E) -4-(Dimethylamino) -2-Butenoic Acid Hydrochloride;(E) -4-Dimethylaminocrotonic Acid Hydrochloride;(2E) -4- (Dimethylamino) asi-2-Enoic Acid Hydrochloride;Afatinib int-2
Nhamba yeCAS	848133-35-7
Stock Status	MuStock, Commerce Scale
Molecular Formula	C6H12ClNO2
Molecular Weight	165.62
Sensitivity	Hygroscopic.Hunyoro Inonzwa
Melting Point	160.0 kusvika 164.0 ℃
Solubility	DMSO (Zvishoma), Methanol (Zvishoma), Mvura (Zvishoma)
COA & MSDS	Available
Origin	Shanghai, China
Brand	Ruifu Chemical

Zvinotsanangurwa:

Item	Zvinotsanangurwa
Chitarisiko	Hupfu Huchena kusvika Hunenge Huchena
Kuchena / Analysis Method	>98.0% (HPLC)
Kuchena / Analysis Method	>98.0% (NMR)
Kunyorova (KF)	<0.50%
Residue paIgnition	<0.20%
Kusachena Kumwechete	<0.50%
Heavy Metals (as Pb)	<20ppm
Infrared Spectrum	Inopindirana neChimiro
1 H NMR Spectrum	Proton NMR Spectrum
Test Standard	Enterprise Standard
Usage	Pakati peAfatinib, Afatinib Dimaleate

Package & Kuchengeta:

Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.

Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza uye unyoro.

KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.

Chromatographic Purity:

Chiridzwa: Agilent 1200 HPLC HPLC chromatograph, DAD detector.
Column: Agilent XDB-C18,250*4.6mm, 5μm
Nharembozha: B: 1.95g sodium octane sulfonate + 8ml phosphoric acid + 5ml triethylamine + 500ml mvura
C: acetonitrile
Kugadzirira kwemusanganiswa wechikamu chenhare: tora 400ml B mhinduro uye 100ml acetonitrile, sanganisa zvakakwana uye zvakaenzana, uye pomba mvura yacho muchikamu chimwe.
Kuyerera mwero: 0.5ml/min54bar
Column tembiricha: 25 ℃
Wavelength: 210nm
Sample solution: mobile phase yakashandiswa se solvent, solid sample: 0.0040g/2ml, saizi yemuenzaniso 2.0μl.

Zvakanakira:

FAQ:

Application:

trans-4-Dimethylaminocrotonic Acid Hydrochloride (CAS: 848133-35-7) inonzi reagent inoshandiswa mukugadzirira tyrosine kinase inhibiting antitumor agents.trans-4-Dimethylaminocrotonic Acid Hydrochloride inogona kushandiswa sepakati peAfatinib (CAS: 439081-18-2), Afatinib Dimaleate (CAS: 850140-73-7), Neratinib (CAS: 698387-09-6).Afatinib mushonga unotenderwa kurapa usiri diki cell lung carcinoma (NSCLC), wakagadzirwa naBoehringer Ingelheim.Inoshanda seangiokinase inhibitor.Kufanana neLapatinib neNeratinib, Afatinib inonzi tyrosine kinase inhibitor (TKI) iyo inodzivisawo zvisingadzoreki inhibits epidermal growth factor receptor 2 (Her2) uye epidermal growth factor receptor (EGFR) kinases.Afatinib haisi kushanda chete kurwisa EGFRshanduko dzakanangwa nechizvarwa chekutanga TKIs likeerlotinib kana gefitinib, asiwo kune avo vasina hanya neaya maitiro ekurapa.Nekuda kwebasa rayo rekuwedzera kurwisa Her2, iri kuongororwa gomarara rezamu pamwe nemamwe EGFR uye Her2 inofambiswa negomarara.Neratinib yakagadziridzwa neUS Wyeth kambani isingachinjiki epidermal kukura factor receptor (EGFR) inhibitor.Iyo yakawanda inotarirwa poindi yediki molecule tyrosine kinase inhibitors kune HER 2 uye HER1 mushure meLapatinib, uye isingachinjike ErbB receptor tyrosine kinase inhibitor.Neratinib inogona kurambidza HER-1 uye HER-2 yeEGFR mhuri (IC50 yaive 92 nmol / L uye 59 nmol / L, zvichiteerana).Tsvagiridzo yekiriniki yakaratidza kuti Neratinib yakaratidza kurapa kwakakosha kune isiri-diki kenza yemapapu, kenza yekoloni, uye kenza yemazamu.The phaseⅡclinical trial yakaratidza kuti Neratinib yakaratidza kushanda zvakanaka uye kushivirira kune HER-2 varwere vane kenza yepamusoro yemazamu avo vakagamuchirwa kana kuti kwete Trastuzumab kurapwa.Chikamu Ⅲ kenza yemazamu kiriniki yekuyedza yakapera munaGunyana 2014.