Vitamin E-TPGS (Tocofersolan) CAS 9002-96-4 D-α-Tocopherol ≥25.0%
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira kugadzira Vitamin E-TPGS (Tocofersolan) (CAS: 9002-96-4) ine mhando yepamusoro.Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga Vitamin E-TPGS,Please contact: alvin@ruifuchem.com
| Chemical Name | Vitamin E Polyethylene Glycol Succinate |
| Mashoko anoreva zvakafanana | Vitamin E-TPGS;TPGS;Tocofersolan;α-Tocopherol Polyethylene Glycol Succinate;D-α-Tocopherol Polyethylene Glycol 1000 Succinate;Alpha-Tocopherol Polyethylene Glycol Succinate |
| Stock Status | MuStock, Commerce Scale |
| Nhamba yeCAS | 9002-96-4 |
| Molecular Formula | C33H54O5.(C2H4O)n |
| Melting Point | 34.0 ~ 38.0℃ |
| Density | 1.01g/cm3 |
| Sensitive | Mhepo Inonzwa, Chiedza Chinonzwisiswa, Kunyorova |
| WGK Germany | 2 |
| Storage Temp. | Nzvimbo Inotonhorera & Yakaoma (2~8℃) |
| COA & MSDS | Available |
| Muenzaniso | Available |
| Chemical Family | Vitamin E Derivative |
| Brand | Ruifu Chemical |
| Items | Kuongorora Maitiro | Results |
| Chitarisiko | Off-White kusvika Pale Yellow Waxy Solid | Zvinoenderana |
| Kuzivikanwa (GC) | Nguva yekuchengeta yenhongonya huru yemuenzaniso mhinduro inoenderana neiyo yeStandard solution | Zvinoenderana |
| Melting Point | 34.0 ~ 38.0℃ | 36.0 ~ 36.6 ℃ |
| Assay D-alpha Tocopherol | ≥25.0% (C29H50O2) | 26.4% |
| Yemahara Tocopherol | ≤1.5% | Zvinoenderana |
| Specific Rotation | ≥+24.0° | +24.5° |
| Solubility mumvura | 20g Muenzaniso Inogona Kunyungudutswa mu80ml Mvura Inofashaira | Pachena Mukati me3 h |
| Acid Value | ≤0.27ml (0.10 N Sodium Hydrooxide) | 0.22ml |
| Masimbi anorema (Pb) | ≤10ppm | <10ppm |
| Arsenic (As) | ≤1ppm | <1ppm |
| Tungamira | ≤3ppm | <3ppm |
| Mercury (Hg) | ≤0.1ppm | <0.010ppm |
| Residual Solvents | ||
| Ethyl Acetate | ≤50ppm | Haina Kuonekwa |
| Ethanol | ≤50ppm | 23ppm |
| Total Plate Count | ≤1000CFU/g | <10CFU/g |
| Mbiriso uye Molds | ≤100CFU/g | <10CFU/g |
| Salmonella | Negative | Negative |
| Escherichia Coli | Negative | Negative |
| Psendomonas Aeruginosa | Negative | Negative |
| Staphylococcus Aureus | Negative | Negative |
| Infrared Spectrum | Inopindirana neChimiro | Zvinoenderana |
| Mhedziso | Chigadzirwa chacho chakaedzwa uye chinoenderana nezvakapihwa | |
Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumudziyo wakavharwa zvakasimba.Chengetedza munzvimbo inotonhorera, yakaoma (2 ~ 8 ℃) uye ine mhepo yakanaka yekuchengetera kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
DEFINITION
Vitamin E Polyethylene Glycol Succinate musanganiswa wakaumbwa ne esterification ye d-alpha tocopheryl acid succinate uye polyethylene glycol.Musanganiswa we ester unosanganisira kunyanya mono-esterified polyethylene glycol uye shoma shoma ye di-esterified polyethylene glycol.Iine NLT 25.0% ye d-alpha tocopherol (C29H50O2).
KUZIVA
• A. Gasi Chromatographic Identification Test
Ongororo: Enderera sekurairwa muyedzo yeZviri muAlpha Tocopherol.
Maitiro ekugamuchira: Nguva yekuchengeta yenhongonya huru yeSample solution inoenderana neiyo yeStandard solution.
COMPOSITION
• Zviri mukati meAlpha Tocopherol
Solvent: 0.25 mL ye phenolphthalein TS mu 1 L yedoro
Internal standard solution: 12 mg/mL ye ethyl arachidate mu isooctane
Mhinduro yakajairwa: Kuendesa 32.5 mg yeUSP Alpha Tocopherol RS kune yakakodzera reaction flask.Wedzera 2 mL yepyridine uye 0.5 mL yeN, O-bis(trimethylsilyl) trifluoroacetamide ne 1% trimethylchlorosilane, uye kupisa flask pa 100 kwemaminitsi gumi.Tonhodza flask, wedzera 5.0 mL yeInternal standard solution inoteverwa ne20 mL yeisooctane, uye zunza.
Sample solution: Tumira huwandu hunoenzana ne 0.100–0.160 g ye Vitamin E Polyethylene Glycol Succinate yakanyungudutswa pa 60 kune tsika chubhu (inenge 20 cm kureba uye 2.5 cm mudhayamita) ine screw cap.Wedzera 40-50 mg ye ascorbic acid uye machipisi mashoma anofashaira, achiteverwa ne20 mL yeSolvent.[Cherechedza-Reflux mhinduro zvinyoro nyoro pasina kuburitsa zviri mukati.] Isa chubhu mumudziyo wekupisa wakaiswa pa100-150.Kana sampu yanyungudika zvakazara, wedzera 0.25 g ye potassium hydroxide, uye ramba uchiita reflux kwemaminitsi makumi matatu.Bvisa chubhu kubva pakupisa, uye zviri mukati zvichiri kupisa, wedzera 1–2 mL yehydrochloric acid inodonha kusvikira ruvara rwepingi rwanyangarika.[Kuchenjerera—Kusagadzikana.Bvumira asidhi kuti idonhe pasi mukati mechubhu kudzivirira kupfachuka.] Tonhodza chubhu, wogeza mativi echubhu ne20 mL yemvura.Wedzera 5.0 mL yeInternal standard solution, cap, uye zunza kuti uve nechokwadi chekusanganisa.Bvumira chubhu kuti imire kusvikira zvidimbu zviviri zvakasiyana zvakaumbwa.Shandura 2.5–3.5 mL yedenga repamusoro mubhokisi rakakodzera rekuita, wowedzera 2.0 mL yepyridine inoteverwa ne2.5 mL yeN,O-bis(trimethylsilyl) trifluoroacetamide ne1% trimethylchlorosilane.Pisa flask pa100 kwemaminitsi gumi.Kutonhorera, uye wobva wawedzera 12 mL ye isooctane.
Chromatographic system
(Ona Chromatography 621, System Suitability.)
Modhi: GC
Detector: Moto ionization
Column: 0.25-mm × 15-m fused-silica capillary;yakavharwa ne0.25-µm firimu rechikamu G27
Tembiricha
Injector: 280
Detector: 345
Column: Ona Tafura 1.
Tafura 1
Initial Temperature(°) Temperature Ramp (°/min) Yekupedzisira Tembiricha (°) Bata Nguva paTembiricha yekupedzisira (min)
260 20 340 1
Mutakuri gasi: Helium
Kuyerera kweyero: 1.5 mL/min
Jekiseni saizi: 1 µL
Mhando yejekiseni: Kupatsanura reshiyo, 200:1
Kukodzera kwehurongwa
Muenzaniso: Standard solution
Kukodzera zvinodiwa
Tailing factor: NMT 2.0 yealpha tocopherol peak
Relative standard kutsauswa: NMT 2.0% yereshiyo yealpha tocopherol peak nzvimbo kune yemukati mwero wepamusoro nzvimbo.
Analysis
Samples: Yakajairwa mhinduro uye Sample Solution
Verenga chikamu che d-alpha tocopherol (C29H50O2) muchikamu cheVitamin E Polyethylene Glycol Succinate yakatorwa:
Mhedzisiro = (RU/RS) × (WS/WU) × 100
RU = yemukati mwero chiyero (nzvimbo yepamusoro yealpha tocopherol / peak nzvimbo yemukati chiyero) kubva kuSample solution
RS = yemukati mwero reshiyo (nzvimbo yepamusoro yealpha tocopherol / nzvimbo yepamusoro yeiyo yemukati chiyero) kubva kune Standard mhinduro
WS= huremu hweUSP Alpha Tocopherol RS yakashandiswa kugadzira iyo Standard solution (mg)
WU= huremu hweVitamin E Polyethylene Glycol Succinate yakatorwa kugadzirira Sample solution (mg)
Maitiro ekugamuchira: NLT 25.0%
ZVIYEDZO ZVAKANAKA
• Optical Rotation, Specific Rotation 781S
[Cherechedza-Iyi bvunzo inoratidza d-alpha tocopherol mushure mekuita saponification.]
Sample solution: Transfer 0.9 g ye Vitamin E Polyethylene Glycol Succinate, yakanyungudutswa pa60, kune yakakodzera test chubhu yakaiswa kepisi, uye inonyungudika mu10.0 mL yedoro.Isa chubhu mumudziyo wekudziya wakaiswa pa100–105.[Cherechedza-Reflux mhinduro zvinyoronyoro pasina kuburitsa zviri mukati.] Kana sampu yanyungudika zvakazara, wedzera 2-3 pellets yesodium hydroxide, uye ramba uchiita reflux kwemamwe 30 min.Bvisa chubhu kubva pakupisa, uye kana zviri mukati zvichiri kupisa, gadzirisa kushandisa phenolphthalein sechiratidzo nekuwedzera zvishoma nezvishoma 10 mL yemusanganiswa wemvura uye hydrochloric acid (1: 1) kusvikira ruvara rwepinki rwapera.[Kuchenjerera-Exothermic kuita.Bvumira mushonga weasidhi udonhe nemukati mechubhu kudzivirira kupfachuka.] Tonhodza chubhu, kepisi, uye zunza kusvika zviri mukati zvanyatsosangana.Wedzera 25.0 mL yeheptane, chivharo, uye zunza kweminiti 1 kuti uone kusanganiswa kwakakwana.Bvumira chubhu kuti imire kusvikira zvidimbu zviviri zvakasiyana zvakaumbwa.Chinja chikamu chepamusoro kune yakachena, yakaoma tsika chubhu, wobva wawedzera 10.0 mL yemvura kune mhinduro yakadzoserwa.Cap, zunza, uye bvumira kuti zvidimbu zviparadzanise.Shandura chikamu chepamusoro kune yakachena, yakaoma chubhu.Wedzera 10.0 mL ye potassium ferricyanide solution, yakagadzirwa nekunyungudutsa 2 g ye potassium ferricyanide mu 10.0 mL ye 0.2 M sodium hydroxide, uye shandura chivharo.Kuzunungusa nesimba kwe45 s, uye bvumira kuti zvidimbu zviparadzanise 30 min.Kana iyo yepamusoro heptane layer yakajeka, enderera mberi nechiyero chekutenderera kwakananga;kana zvisina kujeka, omesa pamusoro peanhydrous sodium sulfate usati waenderera mberi nemuedzo.[Cherechedza-Shandisa zvabuda muyedzo yeZviri muAlpha Tocopherol kuverenga kutenderera chaiko.]
Maitiro ekugamuchira: NLT +24.0
• Solubility muMvura
Muenzaniso: 20 g yeVhitamini E yakanyunguduka Polyethylene Glycol Succinate
Kuongorora: Isa Muenzaniso mumudziyo wegirazi pane magnetic stirrer.Ibva wawedzera 80 mL yemvura iri kufashaira uchikurunga.Bvumira kutonhora kusvika kukamuri yekupisa nekugara uchikurudzira.
Maitiro ekugamuchira: Mhinduro inobuda pachena mukati me3 h.
• Acid Kukosha
Muenzaniso: 1 g ye Vitamin E Polyethylene Glycol Succinate
Ongororo: Dissolve Sample mu 25 mL yemusanganiswa wedoro uye ether (1: 1) iyo yakagadziriswa ku phenolphthalein ine 0.1 N sodium hydroxide.Wedzera 0.5 mL ye phenolphthalein TS, uye titrate ne 0.10 N sodium hydroxide kusvikira mhinduro inoramba iine pink zvishoma mushure mekudengenyeka kwe30 s.
Maitiro ekugamuchira: NMT 0.027 mEq/g, yakaenzana neNMT 0.27 mL ye0.10 N sodium hydroxide
ZVIMWE ZVINODIWA
• Kurongedza uye Kuchengeta: Chengetedza mumidziyo yakaoma, uye chengetedza kubva pachiedza.
• Mazita: Mazita anoratidza d-alpha tocopherol zvirimo, zvinoratidzwa mumg/g.
• USP Reference Standards 11
USP Alpha Tocopherol RS
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
Vitamin E Polyethylene Glycol Succinate (Vitamin E-TPGS; TPGS; Tocofersolan) (CAS: 9002-96-4) chigadzirwa chekugadzira.Inowanikwa seyakachena-kuchena kusvika kucheneruka waxy Yakasimba uye haina kunaka.Kemikari, musanganiswa unoumbwa zvakanyanya ne monoesterified polyethylene glycol 1000, iyo diesterified polyethylene glycol 1000, yemahara polyethylene glycol 1000, uye yemahara tocopherol.
Vitamin E Polyethylene Glycol Succinate yakashandiswa zvakanyanya mukutsvagisa mishonga, sesolubilizer, absorption kukurudzira, emulsifier, plasticizer uye mutakuri wemvura-isina kunyungudika kana mafuta soluble zvinodhaka dhizaini system, senge kupararira kwakasimba, mutakuri wekutengesa zvinodhaka, mutakuri we intranasal. kuendeswa kwezvinodhaka, nezvimwewo Sezvokudya zvinowedzera.
Vitamin E Polyethylene Glycol Succinate imvura inonyungudika kubva muvhitamini E, inoumbwa nekuita carboxyl boka revhitamini E succinate neboka rehydroxyl re polyethylene glycol.Nekuti ine zvese vhitamini E lipophilic boka uye polyethylene glycol hydrophilic refu cheni, ine yakanaka surfactant zvinhu uye solubility mvura, izvo zvinogona kuwedzera zvakanyanya kutorwa kwemishonga isinganyungudika mudumbu, yakawedzera bioavailability.
Mumakore achangopfuura, zvidzidzo zvakawanda zvakawana kuti TPGS haingogoni kushandiswa semishonga inobatsira chete, asiwo ine maitiro akawanda akasiyana-siyana, sekuwedzera kwekunyura uye multidrug resistance reversal agents, TPGS inogonawo kushandiswa kune zvigadzirwa, micelles, liposomes, TPGS-copolymer. vatakuri kuti vavandudze solubility, permeability uye kugadzikana kwegadziriro, kuitira kuti uwane kunonoka, kudzorwa kuburitswa uye kunanga mhedzisiro, kukurudzira kutorwa kwezvinodhaka.
1. Pharmaceutical - Vitamin E-TPGS inowedzera zvakanyanya kubatwa, bioavailability uye kushanda kwemishonga yemishonga (APIs)
2. Zvokudya zvinowedzera - Vitamin E-TPGS inoshandiswa kugadzira zvinowedzera, kunyanya izvo zvakagadzirirwa kuvandudza labsorption yevhitamini E uye mamwe lipophilic nutrients uye nutraceuticals.
3. Chikafu uye Chinwiwa - Vitamin E-TPGS inogona kushandiswa kusimbisa chikafu nezvinwiwa, zvinwiwa zvemitambo, mvura uye muto.
4. Kuchengeta Pachedu - Vitamin E-TPGS inoshanda senge ethanol isina, hypoallergenic, isingagumbure emulsifier/excipient mukuchengeta kwemunhu uye zvizoro.
5. Zvigadzirwa zveMhuka Zvokudya - Vitamin E-TPGS inopa vhitamini E inotorwa zvakanyanya uye inowanika bioavailable kumhuka dzisingatore zvakanaka marudzi ekare evhitamini E.
Vitamin E polyethylene glycol succinate ndeye esterified vhitamini E (tocopherol) inobuda inonyanya kushandiswa sesolubilizer kana emulsifying agent nekuda kweiyo surfactant zvinhu.Zvimiro, ndeye amphipathic uye hydrophilic, kusiyana ne tocopherols, uye naizvozvo inotora mvura-inonyungudutswa inogona kushandiswa mumishonga yemishonga yakadai se capsules, mapiritsi, kupisa-kunyunguduka extrusion, microemulsions, topical products, uye parenterals.Imwe yeanonyanya kukosha mashandisirwo iko kushandiswa kwayo semotokari yelipid-based drug delivery formulations.Inogonawo kushandiswa sechitubu chevhitamini E. Vitamin E polyethylene glycol succinate yakave yakaratidzwa maererano nemaitiro ayo ekuita uye yakadzidzwa sePglycoprotein inhibitor.
Vitamin E polyethylene glycol succinate haienderani nemaasidhi akasimba uye alkali yakasimba.
GRAS yakanyorwa.Inosanganisirwa muFDA Inactive Ingredients Database (ophthalmic solution kana madonhwe; oral capsules, solution, tablet; topical solution kana madonhwe).Inosanganisirwa muCanada Rondedzero Yezvinogamuchirwa Zvisiri-Mushonga Ingredients.
