Zoledronic Acid CAS 118072-93-8 Purity ≥99.7% API Factory High Quality

Tsanangudzo Pfupi

Zita reKemikari: Zoledronic Acid

CAS: 118072-93-8

Chitarisiko: Ichena kusvika Kure-Ichena Crystalline Powder

Kuchena: ≥99.7%

Mukurapa kweHypercalcemia yeMalignancy (HCM)

API High Quality, Commercial Production

Inquiry: alvin@ruifuchem.com


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Tsanangudzo:

Supply with High Purity and Stable Quality
Zita reKemikari: Zoledronic Acid
CAS: 118072-93-8
Iyo ine simba Farnesyl Diphosphate (FPP) Synthase Inhibitor
API High Quality, Commercial Production

Chemical Properties:

Chemical Name Zoledronic Acid
Mashoko anoreva zvakafanana ZOL 446, ZA, Zoledronate, CGP-4244, GP42446A, Zometa, Zomera;[1-Hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid
Nhamba yeCAS 118072-93-8
Nhamba yeCAT RF-API90
Stock Status MuStock, Kugadzirwa Kunokwira Kusvika Mazana emaKilogram
Molecular Formula C5H10N2O7P2
Molecular Weight 272.09
Melting Point 193.0~204.0℃
Brand Ruifu Chemical

Zvinotsanangurwa:

Item Zvinotsanangurwa
Chitarisiko Ichena kusvika kuOff-White Crystalline Powder
Identification IR Spectrum yemuenzaniso inoenderana neiyo yereferensi chiyero
pH 2.0~4.0
Solubility Zvishoma Soluble mu 0.1N Sodium Hydroxide Solution, Inonyungudika zvishoma muMvura uye 0.1N Hydrochloric Acid, Inoita Insoluble muEthanol
Related Substances
Chero Kusachena Kwemunhu ≤0.10%
Zvose Zvisina Kuchena ≤0.30%
Kurasika paKuomesa 5.0%~7.0%
Chloride ≤0.02%
Phosphite ≤0.50%
Phosphate ≤0.50%
Heavy Metals ≤10ppm
Kuchena ≥99.7%
Test Standard Enterprise Standard
Usage API, FPP Synthase Inhibitor, Hypercalcemia yeMalignancy (HCM)

Package & Kuchengeta:

Package: Bhodhoro, Aluminium foil bag, Cardboard dhiramu, 25kg/Drum, kana zvinoenderana nezvinodiwa nemutengi.

Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza, mwando uye tumbuyu.

Zvakanakira:

1

FAQ:

Application:

Zoledronic Acid (CAS 118072-93-8) ine simba bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC50 = 20 nM).Inhibits osteoclast-mediated bone resorption.Zvakare inhibits kusaina kweRas uye kukura kwebundu, uye induces apoptosis mupancreatic cancer maseru.Inodzosera epithelial-mesenchymal shanduko uye inhibits kenza yemazamu sero kuvandudzwa kuburikidza nekusashanda kweNF-κB.Zoledronic acid yakabvumidzwa neUS FDA muna 2001 kurapwa kwe hypercalcemia yemalignancy, metabolic complication inogona kuisa hupenyu munjodzi.Hypercalcemia yemalignancy inogona kuitika kusvika ku50% yevarwere vanoonekwa vaine kenza yepazamu yepamusoro, multiple myeloma, uye nonsmall cell lung cancer.Ichi chiitiko chinomuka apo kemikari inogadzirwa nebundu inokonzeresa kuwanda kweosteoclasts.Kana pane kuwedzera kwekuora kwepfupa, kune kupindirana kwekubudiswa kwe calcium mu plasma.Kana serum yakawandisa yecalcium ichikwira nekukurumidza, itsvo hadzigone kubata iyo yakawandisa, uye hypercalcemia inoguma.Zoledronic acid inonyatso kudzikisa plasma calcium concentrations kuburikidza nekuvharirwa kwebhonzo resorption (inhibition ye osteoclastic chiitiko uye induction ye osteoclast apoptosis).Pamusoro pezvo zoledronic acid yakatenderwa neUS FDA kurapwa kweakawanda myeloma uye bhonzo metastases ine chekuita neakasimba tumor-based cancers (semuenzaniso, prostrate nemapapu).

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