2-Amino-1-Pyrroline Hydrochloride CAS 7544-75-4 daahirnimo>99.5% (HPLC) Tipiracil Hydrochloride Warshada Dhexdhexaadka ah
Soo-saarka wax-soo-saarka, Tayada Sare iyo Qiimaha Tartan
Tipiracil Hydrochloride (CAS: 183204-72-0) Dhexdhexaadiyeyaasha la xidhiidha
6-(Chloromethyl) uracil CAS: 18592-13-7
6-(Hydroxymethyl) uracil CAS: 22126-44-9
2-Amino-1-Pyrroline Hydrochloride CAS 7544-75-4
| Magaca Kiimikada | 2-Amino-1-Pyrroline Hydrochloride |
| La mid ah | 3,4-Dihydro-2H-Pyrrol-5-Amine Hydrochloride;2-Aminopyrrolidine HCl |
| Lambarka CAS | 7544-75-4 |
| Lambarka CAT | RF-PI1838 |
| Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
| Qaanuunka molecular | C4H8N2·HCl |
| Miisaanka Molecular | 120.58 |
| Meesha dhalaalaysa | 171.0 ilaa 175.0 ℃ |
| Xasaasi ah | Hygroscopic |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha | Natiijooyinka |
| Muuqashada | Budada Cad | Budada Cad |
| Daahirnimada / Habka Falanqaynta | > 99.5% (HPLC) | 99.8% |
| Xumaan kali ah ee ugu weyn | <0.50% | 0.09% |
| Waxyaabaha Biyaha (KF) | <0.50% | 0.45% |
| Proton NMR Spectrum | Waafaqsan Qaab-dhismeedka | waafaqsan |
| Heerka Imtixaanka | Heerka Ganacsiga | |
| Isticmaalka | Dhexdhexaadiyaha Tipiracil Hydrochloride (CAS: 183204-72-0) | |
Xidhmada: Dhalo, bacda bireed aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka
2-Amino-1-Pyrroline Hydrochloride (CAS: 7544-75-4) waa unug dabiici ah oo heterocyclic ah, kaas oo loo isticmaali karo dhexdhexaadka dawooyinka.2-Amino-1-Pyrroline Hydrochloride waa dhexdhexaadiye Tipiracil Hydrochloride (CAS: 183204-72-0) ee daawaynta Kansarka Malawadka.Tipiracil Hydrochloride waa horjooge awood leh oo tartan u leh thymidine fosforylase (TPase) oo leh IC50 qiimaha 35 nM ee TPase mandheerta aadanaha.Waxay u doorataa TPase marka loo eego enzymes kale ee pyrimidine-metabolizing (IC50s => 1 mM ee UPase, OPRTase, TK, iyo DPDase).TPI waxay joojisaa fosfooraska iyo hoos u dhaca trifluorothymidine, cytotoxic nucleoside, ee naaska bini'aadamka iyo shaybaarada kansarka mindhicirka.Maamulka afka ee TPI (12.5-50 mg / kg) waxay wanaajisaa waxqabadka anti-buro ee trifluorothymidine ee jiirka AZ-521 kansarka caloosha xenograft.Daawooyinka ka kooban TPI ayaa loo isticmaalay daawaynta kansarka mindhicirka ee metastatic.
