3-Methyl-6-Nitroindazole CAS 6494-19-5 daahirnimo>98.0% (HPLC)
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Magaca Kiimikada | 3-Methyl-6-Nitroindazole |
La mid ah | 3-Methyl-6-Nitro-1H-Indozole;6-Nitro-3-Methylindazole |
Lambarka CAS | 6494-19-5 |
Lambarka CAT | RF2682 |
Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
Qaanuunka molecular | C8H7N3O2 |
Miisaanka Molecular | 177.16 |
Meesha dhalaalaysa | 184.0 ilaa 188.0 ℃ |
Barta Karsan | 384.9 ± 22.0 ℃ |
Cufnaanta | 1.437 |
Solubility | Chloroform (wax yar), methanol (wax yar) |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Jaalle fudud ilaa jaale madow ilaa budada bunni ilaa Crystal |
Daahirnimada / Habka Falanqaynta | >98.0% (HPLC) |
Meesha dhalaalaysa | 184.0 ilaa 188.0 ℃ |
Khasaare xagga qalajinta | <1.00% |
Wadarta wasakhda | <2.00% |
Infrared Spectrum | Waafaqsan Qaab-dhismeedka |
Proton NMR Spectrum | Waafaqsan Qaab-dhismeedka |
Heerka Imtixaanka | Heerka Ganacsiga |
Isticmaalka | Dhexdhexaadiyaha Dawada;Dhexdhexaadiyaha Pazopanib Hydrochloride |
Xidhmada: Dhalo, bacda bireed aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka
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3-Methyl-6-Nitroindazole (CAS: 6494-19-5) waxaa loo istcimaalaa sidii Dhexdhexaadka Farmasiga.Waxa loo isticmaali karaa sidii dhexe ee Pazopanib Hydrochloride (CAS: 635702-64-6).Pazopanib Hydrochloride waxaa baadhay oo soo saaray GlaxoSmithKline, waa jiilka xididada xididada afka ee cusub kaas oo faragelin kara badbaadada burada madax adag iyo koritaanka xididdada dhiigga cusub ee loo baahan yahay.Bartilmaameedka receptor endothelial factor receptor factor (VEGFR), waxay u shaqeysaa iyadoo la joojinayo angiogenesis ee sahayda dhiiga burada.Waxay ku habboon tahay kansarka unugyada kelyaha ee horumarsan (helitaanka unugyada kansarka ee tuubooyinka kelyaha), unugyada jilicsan ee sarcoma (STS), kansarka ugxan-sidaha epithelial iyo daaweynta kansarka sambabada unugyada yaryar (NSCLC).Maamulka Cuntada iyo Dawooyinka ee Mareykanka (FDA) ayaa ansixiyay Oktoobar 19, 2009 in Pazopanib Hydrochloride (magaca ganacsiga Votrient) uu ku jiro liiska, daawaynta lixaad ee la oggolaaday ee kansarka kelyaha tan iyo 2005.