5-Fluorocytosine (5-FC) CAS 2022-85-7 daahirnimada ≥99.5% (HPLC) Capecitabine Emtricitabine Dhexdhexaadiyaha Warshada

5-Fluorocytosine (5-FC) CAS: 2022-85-7 Habka Falanqaynta
Muuqashada-White ama Ku dhawaad ​​White Budada Crystalline
Luminta qallajinta-ku qalaji 105 ilaa 4 saacadood: waxay luminaysaa wax aan ka badnayn 1.50% miisaankeeda.
Hadhaaga dabka-aan ka badnayn 0.1%.
Biraha culus-aan ka badnayn 0.002%.
Fluoride- Isku qas 70 mL oo ah xal cusub oo koloriin ah oo la diyaariyey oo leh 30 ml oo aalkolo isopropyl ah, ka buuxi korantada dusha sare ee saafiga ah, una oggolow korantada inuu ku sii jiro isku dhafka wax aan ka yarayn 2 saacadood ka hor isticmaalka, ama doorbidaya habeen.
Markaad cabbiraadda qaadanayso, ku wareeji xalka 150-mL digsi, oo quusi ​​korantada.Geli baararka wax kicinaya ee polytef-dahaarka leh ee digsiga, ku rid weelka dubista magnetka oo leh dusha dahaaran, una ogolow inaad walaaqdo ilaa dheellitirka laga helayo (qiyaastii 1 ilaa 2 daqiiqo).Biyo raaci oo engeji electrodes inta u dhaxaysa cabbirada, ka taxadar inaadan xoqin kareemka ku jira korantada ion ee gaarka ah.
Cabbir awoodda diyaarinta Heerarka kasta, oo ku sawir feejignaanta fluoride-ka, mg per 100 mL, marka la barbar dhigo kartida, mV, warqad semilogarithmic ah.Cabbir awoodda diyaarinta Tijaabada, oo ka go'aami qalooca caadiga ah fiirsashada fluoride, mg per 100 mL.Xisaabi boqolleyda fluoride ee qaybta Flucytosine ee ay qaadato caanaha:
C / 10
taas oo C ay tahay diiradda fluoride, mg per 100 mL, laga bilaabo qalooca caadiga ah: aan ka badnayn 0.05% ee fluoride ayaa la helay.
Fluorouracil-ku milmi 250 mg 10 mL oo isku dar ah glacial acetic acid iyo biyo (4:1).Codso 20 µL ee xalkan saxan koromograafi ah oo khafiif ah oo lagu dahaadhay lakabka 0.5-mm ee isku dhafka silica chromatographic.Saxan isku mid ah ku dalbo 20 µL, 10-µL kordhin, oo ah 0.025 mg halkii ml ee USP Fluorouracil RS oo isku dar ah glacial acetic acid iyo biyo (4:1).Samee chromatogram-ka isku-dar ah chloroform iyo glacial acetic acid (13:7) ilaa inta hore ee dareeruhu ay ka soo guurto wax aan ka yarayn 14 cm asalka.Ka saar saxanka qolka soo koraya, una ogolow dareeraha inuu uumi baxo.Hel meelaha saxanka ku yaal adiga oo ku eegaya shucaaca UV-mawjadda gaaban: meel kasta oo ka mid ah xalka tijaabada kama weyna cabbirka iyo xoogga meesha ay ku kala duwan yihiin RF ee ay soo saartay xalalka Standard, oo u dhiganta in aan ka badnayn 0.1% fluorouracil.
Assay-Mee ku saabsan 400 mg oo Flucytosine ah, oo si sax ah loo miisaamay, 250-mL beaker, ku dar 150 mL oo isku dar ah 2 muga oo ah glacial acetic acid iyo 1 mugga acetic anhydride, oo milmi, diirran si tartiib ah haddii loo baahdo.Titrate si awood leh oo leh 0.1 N perchloric acid VS, adoo isticmaalaya nidaamka korantada calomel-glass.Samee go'aan maran, oo samee sixid kasta oo lagama maarmaan ah.ML kasta oo ah 0.1 N perchloric acid waxay u dhigantaa 12.91 mg ee C4H4FN3O.Flucytosine wuxuu ka kooban yahay wax aan ka yarayn 98.5 boqolkiiba oo aan ka badnayn 101.0 boqolkiiba C4H4FN3O, oo lagu xisaabiyo sal engegan.