5-Methylisoxazole-4-Carboxylic Acid CAS 42831-50-5 Leflunomide Dhexdhexaad Nadiifnimo>99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. waa saaraha ugu horreeya ee 5-Methylisoxazole-4-Carboxylic Acid (CAS: 42831-50-5) oo leh tayo sare leh.Ruifu waxa uu bixin karaa keenista adduunka oo dhan, qiimo tartan ah, adeeg aad u fiican, tiro yar iyo tiro badan oo la heli karo.Iibso 5-Methylisoxazole-4-Carboxylic Acid,Please contact: alvin@ruifuchem.com
Magaca Kiimikada | 5-Methylisoxazole-4-Carboxylic acid |
La mid ah | 5-Methyl-4-Isoxazolecarboxylic acid |
wasakhnimo | Leflunomide EP wasakh D/ Leflunomide BP wasakh D |
Heerka Saamiyada | Suuqa dhexdiisa, Miisaanka Ganacsiga |
Lambarka CAS | 42831-50-5 |
Qaanuunka molecular | C5H5NO3 |
Miisaanka Molecular | 127.10 g/mol |
Meesha dhalaalaysa | 145.0 ilaa 149.0 ℃ ( shid) |
Cufnaanta | 1.348± 0.06 g/cm3 |
Heerkulka Kaydinta | Meel Qabow & Qallalan (2 ~ 8 ℃) |
COA & MSDS | La heli karo |
Summada | Kiimikada Ruifu |
Walxaha | Heerarka Kormeerka | Natiijooyinka |
Muuqashada | Caddaan ilaa midab jaalle ah budada crystalline, aan ur lahayn | U hogaansama |
Meesha dhalaalaysa | 145.0 ilaa 149.0 ℃ | 147.8-148.5 ℃ |
Khasaare xagga qalajinta | ≤0.50% | 0.13% |
Hadhaaga dabka | ≤0.10% | 0.04% |
Biraha culus (Pb) | ≤0.002% | <0.002% |
3-Methyl Isomeric Compound | ≤0.20% | <0.20% |
Daahirnimada / Habka Falanqaynta | >99.0% (HPLC) | 99.74% |
Infrared Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
1 H NMR Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
Gabagabo | Alaabta waa la tijaabiyay oo waafaqay tilmaamihii la bixiyay | |
Adeegsada | Dhexdhexaadiyaha Dawada ee Leflunomide (CAS: 75706-12-6) |
Xidhmada:Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weel si adag u xiran.Ku kaydi bakhaar qabow, qalalan (2 ~ 8 ℃) iyo bakhaar hawo wanaagsan leh oo ka fog walxaha aan ku habboonayn.Ka ilaali iftiinka iyo qoyaanka.
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Dukumentiyada?Adeegga iibka kadib: COA, MOA, ROS, MSDS, iwm waa la bixin karaa.
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Heerka Khatarta IRRATANT
5-Methylisoxazole-4-Carboxylic Acid (CAS: 42831-50-5) waa dhex dhexaad u ah isku dhafka Leflunomide (CAS: 75706-12-6).Leflunomide waa nooc ka mid ah dawooyinka difaaca jirka ee isoxazole oo leh firfircoonida ka hortagga faafinta, farmashiistaha casriga ah waxay u kala saartaa alaabtan sida dawooyinka antipyretic, xanuunka xanuunka iyo ka hortagga bararka.Alaabtan ayaa si degdeg ah loogu beddeli karaa metabolite firfircoon oo door ka ciyaara beerka iyo cytoplasm xiidmaha iyo microsomes, iyada;Habka ugu muhiimsan waa inta lagu guda jiro isku-darka DNA-ga, xannibaya dhaqdhaqaaqa muhiimka ah ee enzyme-DHODH (DHODH), si ay nucleotide-yada ku dhex jira B-lymphocyte ay dhammaato, waxay joojisaa biosynthesis ee DNA iyo RNA, unugyadu ma geli karaan marxaladda s, ugu dambeyntiina ma geli karaan. bataan, taasoo keentay saamaynta anti-rheumatic, waxay ku habboon tahay daaweynta dadka qaangaarka ah ee leh rheumatoid arthritis-ka firfircoon, ankylosing spondylitis, waxay hoos u dhigi kartaa burburinta lafaha, waxay yareyn kartaa calaamadaha iyo calaamadaha.Intaa waxaa dheer, leflunomide waxay sidoo kale joojin kartaa dhaqdhaqaaqa tyrosine kinase, taas oo ka hortagaysa kororka unugyada T, unugyada B iyo unugyada aan difaaca lahayn, laakiin sidoo kale waxay awood u leedahay, xakamaynta biosynthesis ee cyclooxygenase-2 (COX2), waxay joojisaa isku-darka prostaglandin waxayna ka hortagtaa anti- saamaynta bararka iyo in ay joojiyaan unugyada mast iyo basophils histamine sii daayo.Marka badeecadan loo isticmaalo bukaanada xubinta taranka, hagaajinta qiyaasta waa adag tahay, inta badan waxaa loo isticmaalaa in lagu daaweeyo rheumatoid arthritis-ka iyo cudurrada kale ee difaaca jirka.