6-Amino-5-Bromoquinoxaline CAS 50358-63-9 daahirnimo>99.0% (HPLC) Brimonidine Tartrate Dhexdhexaad
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Magaca Kiimikada | 6-Amino-5-Bromoquinoxaline |
La mid ah | 5-Bromoquinoxalin-6-Amiin;5-Bromo-6-Quinoxalinamine;5-Bromo-6-Aminoquinoxaline |
wasakhnimo | Brimonidine EP wasakhnimada B |
Lambarka CAS | 50358-63-9 |
Lambarka CAT | RF2515 |
Heerka Saamiyada | Kaydka dhexdiisa, Awood Wax-soo-saar 35 Tan bishii |
Qaanuunka molecular | C8H6BrN3 |
Miisaanka Molecular | 224.06 |
Meesha dhalaalaysa | 153.0 ilaa 157.0 ℃ |
Cufnaanta | 1.744±0.06 g/cm3 |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Bunni ilaa budada huruudda fudud |
Daahirnimada / Habka Falanqaynta | >99.0% (HPLC) |
Meesha dhalaalaysa | 153.0 ~ 157.0 ℃ |
Khasaare xagga qalajinta | <1.00% |
Max.Xumaanta Shaqsiga ah | <0.50% |
Wadarta wasakhda | <1.00% |
Infrared Spectrum | Waafaqsan Qaab-dhismeedka |
Proton NMR Spectrum | Waafaqsan Qaab-dhismeedka |
Heerka Imtixaanka | Heerka Ganacsiga |
Isticmaalka | Dhexdhexaadiyaha Brimonidine Tartrate (CAS: 70359-46-5) |
Meesha dhalaalaysa
Isticmaal habka baaritaanka guud oo kordhi heerkulka 1.5℃/daqiiqo.Waa inay dhalaalisaa inta u dhaxaysa 153.0 ~ 157.0 ℃
Khasaare xagga qalajinta
Aan ka badnayn 1.0% Waxaa lagu go'aamiyay 1.0g iyadoo lagu qallajinayo foornada 105 ℃ ilaa miisaan joogto ah
Iskudhisyada la xidhiidha (HPLC)
Nidaamka Chromatographic:
Tiirka: ODS, C18,
Mawjadaha wax baadha: 264nm
Heerka socodka: 1.0 ml daqiiqadii
Marxaladda mobilada:
Diyaarso isku dhafka la sifeeyay oo la nadiifiyey ee bakhaar (ku milmi 2.6g Sodium 1-heptanesulfonate 690ml oo biyo ah) -methanol-glacial acetic acid-trietylamine (690:310:7.5:2.5).
Tusaalaha diyaarinta xalka:
Ku mil muunad si sax ah loo miisaamay oo ah 25.0mg gudaha 25ml wajiga wareega
Habka:
Duri mugga 10 l ee xalka muunada oo ku duub chromatogram-yada 4 jeer wakhtiga haynta ee ugu sarreysa.Xisaabi meelaha ugu sarreeya ee wasakhdu waxay yareeyaan meesha ugu sarreysa ee bannaan.Wadarta guud
wasakhda aan ka badnayn 1.00%, wasakh kasta oo aan ka badnayn 0.50%.
Jidka Synthesis ee 6-Amino-5-Bromoquinoxaline (CAS: 50358-63-9)
Xidhmada: Dhalo, bacda bireed aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka
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Dukumentiyada?Adeegga iibka kadib: COA, MOA, ROS, MSDS, iwm waa la bixin karaa.
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6-Amino-5-Bromoquinoxaline (CAS: 50358-63-9) waa dhexdhexaad muhiim ah oo ka mid ah derivatives quinoxaline.6-Amino-5-Bromoquinoxaline waxaa loo istcimaalaa dhexdhexaadka dawooyinka, dhexdhexaadinta Brimonidine Tartrate (CAS: 70359-46-5).Brimonidine waa xannibaade α2-receptor ah oo si heer sare ah loo xushay, oo ay si guul leh u soo saartay Shirkadda Allergan ee Maraykanka, taas oo ah daawada indhaha.Waxay yarayn kartaa cadaadiska intraocular (IOP).Brimonidine Tartrate xalinta indhaha ee suuqa ayaa ah qaabka brimonidine tartrate, taas oo ah daawo hooseysa IOP wanaagsan oo loogu talagalay glaucoma xagal furan oo dabadheeraad ah iyo daaweynta hypertension indhaha ee bukaanka, laakiin sidoo kale loogu talagalay heerarka laser argon IOP.Xalka indhaha ee Brimonidine Tartrate waxa uu leeyahay hab laba hab oo ficil ah iyada oo la dhimayo wax soo saarka kaftanka aqueous iyo kordhinta lakabka midabka ee ujeedooyinka daaweynta scleral dareeraha ah.Ka dib markaad hoos u dhigto isha, saameyntu waa mid degdeg ah, waxayna gaari kartaa meesha ugu sarreysa marka la isticmaalayo ilaa 2h, iyo waqtiga waxtarka leh wuxuu ilaalin karaa 12h.Dhiiggu wuxuu ogaan karaa oo kaliya raadadka daroogooyinka.Alaabtani waxay leedahay dheef-shiid kiimikaad hore ee beerka, iyo dheef-shiid kiimikaad oo ay ka soo baxaan kaadida ee kelyaha.Nuugista nidaamka iyo qaybinta ma saameeyaan, iyo waayeelka uma baahna hagaajin qiyaasta.Xalka indhaha ee Brimonidine Tartrate marka la barbar dhigo kuwa kale ee α-blockers, dufanka-soluble waa yar yahay, halka aysan sahlanayn in la dhex maro xannibaadda dhiigga-maskaxda oo aan soo saarin suuxdin, dhiig-yaraan iyo fal-celin kale oo la mid ah clonidine dhexe.