6-O-Methylguanine CAS 20535-83-5 Warshada Dhexe ee Nelzarabine
Bixinta Nadiif Sarreysa, Wax Soo Saarka Ganacsiga
Magaca Kiimikada: 6-O-Methylguanine
CAS: 20535-83-5
| Magaca Kiimikada | 6-O-Methylguanine |
| La mid ah | 2-Amino-6-Methoxypurine |
| Lambarka CAS | 20535-83-5 |
| Lambarka CAT | RF-PI509 |
| Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
| Qaanuunka molecular | C6H7N5O |
| Miisaanka Molecular | 165.16 |
| Meesha dhalaalaysa | > 300 ℃ ( shid) |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Budada Crystalline Off-White |
| Habka Qiimaynta / Falanqaynta | ≥98.5% (HPLC) |
| Khasaare xagga qalajinta | ≤0.50% |
| Hadhaaga dabka | ≤0.50% |
| Wadarta wasakhda | ≤1.5% |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | Dhexdhexaadka Nelzarabine (CAS: 121032-29-9), T-ALL & T-LBL |
Xidhmada: Dhalo, bacda bireed ee aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka.
6-O-Methylguanine (CAS: 20535-83-5) waxaa loo isticmaali karaa dhex-dhexaadinta isku-dhafka Nelzarabine (CAS: 121032-29-9).Nelarabine waa daawo loogu talagalay deoxyguanosine analogue-9-beta-D-arabinofuranosyl guanine (ara-G).Nelarabine demethylates ee doorka adenosine deaminase (ADA) oo isu beddela ara-G.Nelarabine waxaa markii ugu horreysay si guul leh u soo saartay GlaxoSmithKline.Oktoobar 28, 2005 iyadoo la raacayo oggolaanshaha Maamulka Cunnada iyo Dawooyinka ee Mareykanka, waxay noqotay daawo cusub oo loogu talagalay daawaynta T-cell acute lymphoblastic leukemia (T-ALL) iyo T-Cells lymfoblasticlymphoma (T-LBL) kuwaas oo adkaysi u leh ugu yaraan. laba nooc oo daawaynta kiimoterabiga ah ama soo noqnoqda ka dib daawaynta hore.Daawadaan cusub ayaa si rasmi ah loogu taxay dalka Mareykanka 2006dii.
