7-Methoxy-1-Naphthaleneacetic Acid CAS 6836-22-2 daahirnimo>99.5% (HPLC) Agomelatine Dhexdhexaadiyaha Warshada
Soo saaraha hormuudka ah iyo iibiyaha Agomelatine Intermediates
Agomelatine CAS 138112-76-2
7-Methoxy-1-Tetralone CAS 6836-19-7
7-Methoxy-1-Naphthaleneacetic Acid CAS 6836-22-2
7-Methoxy-1-Naphthylacetonitrile CAS 138113-08-3
7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester CAS 6836-21-1
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| Magaca Kiimikada | 7-Methoxy-1-Naphthaleneacetic Acid |
| La mid ah | (7-Methoxy-1-Naphthyl) acetic acid;2- (7-Methoxynaphthalen-1-yl) acetic acid;2- (7-Methoxy-1-Naphthyl) acetic acid |
| Lambarka CAS | 6836-22-2 |
| Lambarka CAT | RF2688 |
| Heerka Saamiyada | Kaydka dhexdiisa, Awood Wax-soo-saar 20 Tan bishii |
| Qaanuunka molecular | C13H12O3 |
| Miisaanka Molecular | 216.24 |
| Meesha dhalaalaysa | 153.0 ilaa 158.0 ℃ |
| Barta Karsan | 408.8 ± 20.0 ℃ |
| Cufnaanta | 1.235 |
| Solubility | Ku milma Methanol |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Budada Adag ee Jaallaha fudud |
| Daahirnimada / Habka Falanqaynta | > 99.5% (HPLC) |
| Meesha dhalaalaysa | 153.0 ~ 158.0 ℃ |
| Khasaare xagga qalajinta | <0.50% |
| Hadhaaga dabka | <0.20% |
| Xumaanta Keliya | <0.50% |
| Wadarta wasakhda | <0.50% |
| 1 H NMR Spectrum | Waafaqsan Qaab-dhismeedka |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | Dhexdhexaadiyaha Dawooyinka ee Agomelatine (CAS: 138112-76-2) |
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7-Methoxy-1-Naphthaleneacetic Acid (CAS: 6836-22-2) waa dhexdhexaad Aomelatine (CAS: 138112-76-2).Agomelatine waa daawada niyad-jabka ee loo isticmaalo daawaynta niyad-jabka.Maskaxdu inta badan way ku fiican tahay hubinta inaan haysano kiimikooyinka aan u baahanahay si aan si sax ah ugu shaqeyno.Laakiin niyad-jabku wuxuu saameyn karaa tiro kiimikooyin maskaxda ah.Kiimikooyinkaas waxaa ka mid ah noradrenaline, dopamine iyo serotonin;niyad-jabku waxa uu yareeyaa heerarka gudbiyaha maskaxda.Niyad-jabka sidoo kale wuxuu saameeyaa kiimiko la yiraahdo melatonin.Melatonin oo yaraatay waxay ku xidhan tahay khalkhal ku yimaada qaabka hurdada.Agomelatine waa daawada niyad-jabka ee ugu horreysa ee kordhisa dhaqdhaqaaqa melatonin si toos ah.Tani waxay ku samaynaysaa iyada oo u dhaqmaysa sida melatonin ee goobaha bartilmaameedka ah ee melatonin ka shaqeyso.(Kuwaan waxaa loo yaqaanaa melatonin reseptors).Marka la kordhiyo dhaqdhaqaaqa melatonin, agomelatine wuxuu kaloo si toos ah u kordhiyaa dhaqdhaqaaqa noradrenaline iyo dopamine.Agomelatine waxay leedahay saameyn liddi ku ah walaaca, waxay nafisisaa hurdo la'aanta dadka qaba niyad-jabka.Agomelatine waxa uu nidaamiyaa wareegga hurdada ee jidhka.Agomelatine waa horumar laga gaaray daaweynta niyad-jabka.Agomelatine waxaa soo saartay shirkadda dawooyinka ee Servier.Waxaa loo suuq geeyaa daaweynta xanuunka weyn ee niyad-jabka waxaana lagu soo warramey inaysan soo saarin xanuunka joojinta oo aysan lahayn wax saameyn ah oo galmo ah marka loo eego SSRIs, SNRIs iyo antidepressants tricyclic ka weyn.Agomelatine waxa kale oo laga yaabaa inay saameyn togan ku yeelato hurdada.
