7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester CAS 6836-21-1 daahirnimo>99.0% (GC) Agomelatine Dhexdhexaad
Soo saaraha hormuudka ah iyo iibiyaha Agomelatine Intermediates
Agomelatine CAS 138112-76-2
7-Methoxy-1-Tetralone CAS 6836-19-7
7-Methoxy-1-Naphthaleneacetic Acid CAS 6836-22-2
7-Methoxy-1-Naphthylacetonitrile CAS 138113-08-3
7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester CAS 6836-21-1
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| Magaca Kiimikada | 7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester |
| La mid ah | Ethyl 2-(7-Methoxynaphthalen-1-yl) acetate |
| Lambarka CAS | 6836-21-1 |
| Lambarka CAT | RF2687 |
| Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
| Qaanuunka molecular | C15H16O3 |
| Miisaanka Molecular | 244.29 |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Dareeraha Hufan ee Jaallaha fudud |
| Daahirnimada / Habka Falanqaynta | >99.0% (GC) |
| Biyaha (waxaa qoray Karl Fischer) | <0.50% |
| Walxaha laxidhiidha | <1.00% |
| Infrared Spectrum | Waafaqsan Qaab-dhismeedka |
| NMR Spectrum | Waafaqsan Qaab-dhismeedka |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | Dhexdhexaadiyaha Dawooyinka ee Agomelatine (CAS: 138112-76-2) |
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7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester (CAS: 6836-21-1) waa mid dhexdhexaad ah oo dabiici ah oo faa'iido leh, oo loo isticmaali karo dhexdhexaadka daawada Aomelatine (CAS: 138112-76-2).Agomelatine, oo ay soo saartay shirkadda Faransiiska Servier, waa melatonin-ka ugu horreeya adduunka ee MT1 iyo MT2 agonist ee daawada niyad-jabka.Waxay khusaysaa daaweynta bukaanka qaangaarka ah ee qaba niyad-jabka daran.Agomelatine waa daawada niyad-jabka.Agomelatine waa agonist of melatonin (MT) reseptors iyo derivative of melatonin.Waxay ku xidhan tahay MT1 iyo MT2 reseptors (Kis = 0.14 iyo 0.41 nM, siday u kala horreeyaan) oo waxay leedahay EC50 qiimaha 0.1 nM ee [35S] GTPγS ku xidhidhiyaha iyadoo la adeegsanayo unugyada CHO ee muujinaya soo-qabayaasha MT2.Waxaa loo kala saaraa sida norepinephrine-dopamine disinhibitor (NDDI) sababtoo ah ka soo horjeeda soo-dhoweeyaha 5-HT2C.Dhaqdhaqaaqa 5-HT2C reseptors ee serotonin ayaa joojisa sii deynta dopamine iyo norepinephrine.
