7-Methoxy-1-Naphthylacetonitrile CAS 138113-08-3 daahirnimo>99.0% (HPLC) Agomelatine Dhexdhexaad
Soo saaraha hormuudka ah iyo iibiyaha Agomelatine Intermediates
Agomelatine CAS 138112-76-2
7-Methoxy-1-Tetralone CAS 6836-19-7
7-Methoxy-1-Naphthaleneacetic Acid CAS 6836-22-2
7-Methoxy-1-Naphthylacetonitrile CAS 138113-08-3
7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester CAS 6836-21-1
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| Magaca Kiimikada | 7-Methoxy-1-Naphthylacetonitrile |
| La mid ah | 7-Methoxy-1-Naphthylmethylcyanide;7-Methoxy-1-Naphthaleneacetinitrile;1-Cyanomethyl-7-Methoxynaphthalene;2- (7-Methoxy-1-Naphthyl) acetonitrile;2- (7-Methoxynaphthalen-1-yl) acetonitrile;Agomelatine wasakh 12;Dhexdhexaadiyaha Aomelatine 1 |
| Lambarka CAS | 138113-08-3 |
| Lambarka CAT | RF2504 |
| Heerka Saamiyada | Kaydka dhexdiisa, Awood Wax-soo-saar 30 Tan bishii |
| Qaanuunka molecular | C13H11NO |
| Miisaanka Molecular | 197.24 |
| Meesha dhalaalaysa | 83.0 ilaa 86.0 ℃ |
| Cufnaanta | 1.135±0.06 g/cm3 |
| Tusmada N20/D | 1.44 |
| Solubility | Ku milma Methanol |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Budada Jaallaha fudud |
| Daahirnimada / Habka Falanqaynta | >99.0% (HPLC) |
| Meesha dhalaalaysa | 83.0 ~ 86.0 ℃ |
| Khasaare xagga qalajinta | <0.50% |
| Hadhaaga dabka | <0.20% |
| Xumaanta Keliya | <0.50% |
| Wadarta wasakhda | <1.00% |
| Biraha culus | <20ppm |
| Proton NMR Spectrum | Waafaqsan Qaab-dhismeedka |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | Dhexdhexaadiyeyaasha Dawooyinka;Dhexdhexaadiyaha Aomelatine |
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7-Methoxy-1-Naphthylacetonitrile (CAS: 138113-08-3) waa dhexdhexaad Aomelatine (CAS: 138112-76-2).Agomelatine, oo ay soo saartay shirkadda Faransiiska Servier, waa melatonin-ka ugu horreeya adduunka ee MT1 iyo MT2 agonist ee daawada niyad-jabka.Agomelatine waxay quseysaa daaweynta bukaanada qaangaarka ah ee qaba niyad-jabka daran.Agomelatine waa daaweeyaha cusub ee niyad-jabka leh ee leh ficillada agonist-ka ee xulashada melatonin reseptors iyo ficil antagonist xulashada ee serotonin 5HT-2C reseptors.Ma saameynayso qaadashada serotonin, noradrenaline ama dopamine.Agomelatine waxay kaa caawin kartaa habaynta saacada jidhkaaga (xanuunka wareegga wareegga) oo leh faa'iidooyin togan oo ku saabsan niyadda iyo niyad-jabka hurdada Agomelatine waxaa loo isticmaalaa daawaynta niyad-jabka ama si looga hortago soo noqoshada niyad-jabka, oo keliya ayaa lagu heli karaa warqad dhakhtar.Agomelatine - Xanuunka Dhimirka Qayb kale oo ah "blockbuster" oo ah daroogo.Agomelatine wuxuu leeyahay daaweeyaha niyad-jabka, ka-hortagga werwerka, hagaajinta laxanka hurdada iyo nidaaminta doorka saacadda noolaha, iyo falcelinteeda xun, waxqabadka galmada iyada oo aan lahayn saameyn xun, iyo jawaab celin la'aan.Agomelatine waxay saameyn wanaagsan ku leedahay bukaanada qaba niyad-jabka, falcelinta xunna aad ayey u yar tahay.Qiyaasta lagu taliyey ee Agomelatine guud ahaan waa 25mg maalin kasta nus saac gudahood ka hor hurdada.
