Acesulfame K CAS 55589-62-3 Acesulfame Potassium Purity>99.0% (HPLC)

Qeexitaan
Acesulfame Potassium wuxuu ka kooban yahay NLT 99.0% iyo NMT 101.0% ee C4H4NO4SK, oo lagu xisaabiyo sal qallalan.
AQOONSIGA
• A. NUUXA NUUXDA AH <197K>
B. Tijaabooyinka Aqoonsiga-GUUD, Potassium <191>
Tusaalaha xalalka: 100 mg/mL
Shuruudaha aqbalaadda: Buuxiyay shuruudaha
ASSAY
HABKA
Tusaale: 150 mg
Nidaamka Titrimetric (Eeg Titrimetry <541>)
Habka: Titration toos ah
Titrant: 0.1 N perchloric acid VS
Banaan: 50 ml oo ah glacial acetic acid
Ogaanshaha barta dhamaadka: Potentiometric
Falanqaynta: Ku mil muunada 50 mL ee glacial acetic acid.
Titrate leh 0.1 N perchloric acid VS.Samee go'aan maran.
Xisaabi boqolkiiba acesulfame potassium (C4H4NO4SK) ee Tusaalaha:
Natiijadu = [(V - B) × N × F × 100]/W
V = mugga titrant ee uu isticmaalo Tusaalaha (mL)
B = mugga titrant ee uu isticmaalo Bannaanka (mL)
N = titrant caadiga ah ee dhabta ah (mEq/mL)
F = qodob u dhigma, 201.2 mg/mEq
W = miisaanka Tusaalaha (mg)
Shuruudaha aqbalaadda: 99.0%-101.0% ee salka qallalan
XANUUNKA
XADKA FLUORID
[FIIRO GAAR AH- Isticmaal balaastikada tijaabadan oo dhan.]
Xalka A: Ku mil 210 g oo ah citric acid monohydrate 400 ml oo biyo ah.Ku hagaaji ammonia-kooxeed pH 7.0, oo ku qas biyo ilaa 1000 ml.
Xalka B: 132 mg/mL oo ah ammonium phosphate dibasic
Xalka C: Joojinta 292 g oo ah edetic acid 500 ml oo biyo ah, ku dar 200 ml ammonium hydroxide, ku hagaaji ammonium hydroxide pH inta u dhaxaysa 6 iyo 7, oo ku milo biyo si aad u samayso 1000 mL.
Xalka Buffer: Isku qas qiyaas siman oo ah Xalka A, Xalka B iyo Xalka C, oo ku hagaaji ammonium hydroxide pH ee 7.5.
Xalka kaydka caadiga ah: Miisaanka 0.442 g oo ah fluoride sodium, oo hore loo qalajiyey 300 ° 12 saacadood, geli galaaska mugga 1-L, oo ​​biyo ku qas mugga.Ku kaydi xalka weel bac ah oo xiran.Isla markiiba ka hor intaan la isticmaalin, tuubada 5 mL ee xalkan ku rid weel mugga 100-mL, oo ​​ku qas biyo ilaa mugga.ML kasta oo ka mid ah xalalkani waxa uu ka kooban yahay 10µg oo ah fluoride ion.
Xalka caadiga ah A: Isku qas 0.5 mL oo ah xalalka caadiga ah iyo 15.0 ml ee xalalka Buffer, oo ku qas biyo ilaa 50ml.
Xalka caadiga ah ee B: Isku qas 1.0 mL oo ah xalalka caadiga ah iyo 15.0 ml ee xalalka Buffer, oo ku qas biyo ilaa 50ml.
Xalka caadiga ah C: Isku qas 1.5 mL oo ah xalalka caadiga ah iyo 15.0 mL ee xalalka Buffer, oo ku qas biyo ilaa 50ml.
Xalka caadiga ah D: Isku qas 3.0 mL oo ah xalalka caadiga ah iyo 15.0 ml ee xalalka Buffer, oo ku qas biyo ilaa 50ml.
Xalka muunada: 50-mL weel mug leh ku dar 3 g oo Potassium Acesulfame ah.Ku milmi biyaha, ku dar 15.0 mL oo ah xalka Buffer, oo ku mil biyo ilaa mugga.
Falanqaynta
Tusaalooyinka: Xalka caadiga ah A, Xalka caadiga ah B, Xalka caadiga ah C, Xalka caadiga ah D, iyo xal muunad
Si wada jir ah u cabbir kartida (eeg Titrimetry <541>) ee mV, ee xalalka caadiga ah iyo xalka Tusaalaha, oo leh mitirka pH ee ku habboon oo ku qalabaysan korantad gaar ah oo fluoride ah iyo electrode tixraac ah oo koloride-silver ah.Markaad cabbiraadda qaadanayso, ku wareeji xalka 25-mL beeriye, oo quusi ​​electrodes-ka.Geli birta wax kicinaysa ee dahaarka leh ee birta gasha, ku rid weeliyaha saara kiciya magnetka leh oo leh dusha dahaaran una ogolow inuu walaaqo ilaa laga helayo dheellitirka (1-2 daqiiqo).Biyo raaci, oo qalaji electrodes inta u dhaxaysa cabbirada, ka taxadar inaadan xoqin kareemka ku jira korantada ion-gaar ah ee fluoride.Cabbir awoodda xal kasta oo Heerarka ah, oo ku sawir feejignaanta fluoride, µg/ml, oo ka soo horjeeda awoodda, mV, warqad semilogarithmic ah.Cabir awoodda muunad xal, oo go'aami fiirsashada fluoride ka qalooca caadiga ah, µg/ml.
Xisaabi waxa ku jira ppm, ee fluoride ee qaybta Acesulfame Potassium ee laga qaatay:
Natiijadu = (V × C/W)
V = mugga xalka muunada (mL)
C = fiirsashada fluoride ee xalka Tusaalaha, laga bilaabo qalooca caadiga ah (mg/mL)
W = Miisaanka Acesulfame Potassium oo la qaaday si loogu diyaariyo muunad xal (g)
Shuruudaha aqbalaadda: NMT 3 ppm
• Biraha culus, Habka I <231>: NMT 10 ppm
• NADAAFADDA CHOMATOGARAPHIC
Xalka A: 3.3 mg/mL oo ah tetrabutylammonium hydrogen sulfate
Marxaladda mobilada: Acetonitrile iyo Solution A (2:3)
Xalka ku habboonaanta nidaamka: 2 µg/ml midkiiba USP Acesulfame Potassium RS iyo ethylparaben
Xalka caadiga ah: 0.2 µg/ml oo ah USP Acesulfame Potassium RS
Tusaalaha xalalka: 10 mg/mL
Nidaamka Chromatographic
(Fiiri Chromatography <621>, Habboonaanta Nidaamka.)
Habka: LC
Baaraha: UV 227 nm
Tiirka: 4.6-mm × 25-cm;5-µm xirmo L1
Heerka socodka: 1 ml/min
Cabbirka duritaanka: 20 µL
Ku habboonaanta nidaamka
Tusaalaha: Xalka ku habboonaanta nidaamka
Shuruudaha ku habboonaanta
Xallinta: NLT 2 inta u dhaxaysa acesulfame potassium iyo ethylparaben
Falanqaynta
Tusaalooyinka: Xalka caadiga ah iyo xalalka muunada
Ku duub chromatogram-yada wakhti run ah NLT 3 jeer wakhtiga haynta ugu sarraysa potassium-ka, oo cabbir jawaabaha aagga meelaha ugu sarreeya.
Shuruudaha aqbalaadda: Jawaabta wax kasta oo ugu sarreeya ee wakhtiga haynta ee aan ka ahayn ta acesulfame potassium ee ka timaadda muunadda kama badna jawaabta ugu sarreysa potassium acesulfame ee xalka Heerka (0.002%).
IMTIXAANO GAAR AH
• ACIDITY AMA ALKALIN
Xalka Tusaalaha: 4.0 g 20 ml oo biyo ah oo aan lahayn kaarboon laba ogsaydh
Falanqaynta: Ku dar 0.1 ml oo bromothymol buluug ah TS.Haddii xalku yahay jaalle, titrate leh 0.01 N sodium hydroxide si loo soo saaro midab buluug ah.Haddii xalku buluug yahay, titrate leh 0.01 N hydrochloride acid si loo soo saaro midab huruud ah.
Shuruudaha aqbalaadda: NMT 0.2 mL ee 0.01 N sodium hydroxide ama NMT 0.2 mL ee 0.01 N hydrochloric acid ayaa loo baahan yahay.
• luminta qallajinta <731>: Ku qalaji muunad 105° 3 saac: waxay luminaysaa NMT 1.0% miisaankeeda.
SHURUUD DHEERAAD AH
Baakadaha iyo Kaydinta: Ku kaydi weel si fiican u xidhan, kana ilaali iftiinka.Ku kaydi heerkulka qolka.
HEERARKA Tixraaca USP <11>
USP Acesulfame Potassium RS