S-Adenosyl-L-Methionine (Ademetionine; SAME) CAS 29908-03-0
Kiimikada Ruifu waa saaraha ugu horreeya ee S-Adenosyl-L-Methionine (Ademetionine; SAME) (CAS: 29908-03-0) oo leh tayo sare.Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibso S-Adenosyl-L-Methionine,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | S-Adenosyl-L-Methionine |
| La mid ah | Ademetionine;S-Adenosylmethionine;SAME;SAM;AdoMet |
| Heerka Saamiyada | Suuqa dhexdiisa, Wax-soo-saarka Ganacsiga |
| Lambarka CAS | 29908-03-0 |
| Qaanuunka molecular | C15H22N6O5S |
| Miisaanka Molecular | 398.44 g/mol |
| Meesha dhalaalaysa | 267.0 ~ 269.0 ℃ |
| Xasaasi ah | Aad u Hygroscopic |
| Biyuhu milmayn | Ku milmay Biyaha |
| Urta & Dhadhanka | Astaamaha |
| COA & MSDS | La heli karo |
| Tusaale | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Summada | Kiimikada Ruifu |
| Walxaha | Tilmaamaha | Natiijooyinka |
| Muuqashada | Ku dhawaad Budada Fiican ee Cad (Aad u Hygroscopic) | La xaqiijiyay |
| Solubility | Ku milmay Biyaha | |
| Aqoonsiga | 1. falcelinta kiimikada | Falcelin togan |
| 2. IR: Waafaqsan spectrum la helay RS | La xaqiijiyay | |
| 3. Wakhtiga haynta ee ugu sarraysa waxa ay buuxisaa codsiyada | La xaqiijiyay | |
| Qiimaha acid | 1.5 ~ 2.5 | 1.9 |
| Cadaynta iyo Midabka Xalka | Aan Ka Midab Badnayn RS Y1 | La xaqiijiyay |
| Biyaha waxaa qoray Karl Fischer | ≤3.00% | 2.2% |
| Hadhaaga dabka | ≤0.30% | 0.14% |
| Biraha culus (Pb) | ≤10pm | <10pm |
| Endotoxin | ≤0.3EU/mg | La xaqiijiyay |
| Microbiological | Waa in uu buuxiyo shuruudaha | |
| Wadarta tirada saxanada | ≤1000cfu/g | 55cfu/g |
| Khamiirka & Caaryada | ≤100cfu/g | 12cfu/g |
| E. Coli | Maqan/10g | U hogaansama |
| S. Aureus | Maqan/10g | U hogaansama |
| Salmonella | Maqan/10g | U hogaansama |
| S-Adenosyl-L-Homocysteine | ≤0.50% | 0.10% |
| Meththioadenosine | ≤1.00% | 0.24% |
| Adenine | ≤0.50% | 0.09% |
| Walxaha laxidhiidha | ||
| Wasakhda Kale Ee Ugu Weyn | ≤0.20% | 0.01% |
| Wadarta guud ee wasakhda kale | ≤0.50% | 0.006% |
| (S,S) Ismer | >62.0% | 79.4% |
| Butanedisulfonate | 46.0 ~ 49.0% (Saloolka la qalajiyey) | 47.5% |
| Ademetionine | 50.0 ~ 53.0% (Saloolka la qalajiyey) | 52.1% |
| Wadarta nuxurka | > 97.5% (ku salaysan qalalan) | 99.6% |
| Gabagabo | Alaabtu waa la tijaabiyay oo waafaqday tilmaamihii la bixiyay | |
| Nolosha shelf | 2 Sano Marka Si Wanaagsan loo kaydiyo | |
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S-Adenosyl-L-Methionine (Ademetionine; SAME) (CAS: 29908-03-0) waa cosubstrate caadi ah oo ku lug leh wareejinta kooxda methyl.SAME waxaa markii ugu horeysay laga helay Talyaaniga GL Cantoni 1952, SAME waa molecule ay si joogto ah u soo saaraan dhammaan unugyada noolaha, waxay ka hortagi karaan kansarka beerka, kor u qaadida unugyada cartilaginous samaynta iyo isku dhejinta, waxay kaa caawin kartaa la dagaallanka niyad-jabka, cudurka alzheimer, cudurka beerka, iyo xanuunka osteoarthritis, SAME hadda caalamka oo dhan ayaa loo aqoonsan yahay inay tahay dawooyin muhiim ah oo lagu daweeyo cudurrada beerka.Maanta SAME waxaa caadi ahaan loo isticmaalaa dawooyinka, warshadaha cuntada daryeelka caafimaadka labadaba suuqa gudaha iyo kan caalamiga ah.SAME waxaa lagu iibiyaa Maraykanka si kabitaan cunto ah.
1. S-Adenosyl-L-Methionine waa nafaqo u fiican beerka, taas oo ka hortagi karta khamriga, daroogada iyo unugyada beerka;
2. S-Adenosyl-L-Methionine waxay saameyn weyn oo ka hortag ah ku leedahay cagaarshowga firfircoon ee joogtada ah iyo arrimo kale oo keena dhaawaca beerka, cudurrada wadnaha, kansarka iyo wixii la mid ah.
3. S-Adenosyl-L-Methionine waxa la ogaaday in uu waxtar u leeyahay sida dawooyinka lagu daweeyo xanuunka lafaha iyo niyad jabka wayn.
4. Dalka Maraykanka, SAM waxa lagu iibiyaa kaab nafaqo ahaan iyada oo hoos imanaysa magaca suuq-gaynta SAM-e (sidoo kale loo higaadiyay SAME ama SAME).Daraasadaha qaarkood ayaa muujiyay in qaadashada SAM ee joogtada ah ay kaa caawin karto la dagaallanka niyad-jabka, cudurka beerka, iyo xanuunka lafaha lafaha.Tijaabooyin caafimaad oo dhowr ah ayaa muujiyay inay u roon tahay niyad-jabka, cudurrada beerka qaarkood iyo lafo-xanuunka.Dhammaan calaamadaha kale lama xaqiijin.
5. Si kiliinik ahaan loo isticmaalo si loo hagaajiyo shaqada beerka.Isku darka L-DOPA ee daaweynta cudurka Parkinson waxay wanaajin kartaa waxtarka L-dopa waxayna yareyn kartaa dhibaatooyinka soo raaca.Xanuun maxalli ah, walaac ku meel gaar ah iyo hurdo la'aan meesha la duray ayaa la arki karaa.
S-Adenosyl-L-Methionine (Ademetionine; SAME) (CAS: 29908-03-0) sidoo kale waxay leedahay saameyn daweyn oo wanaagsan oo ku saabsan arthritis-ka, murqaha fibreska, madax xanuunka dhanjafka iyo cudurrada kale, waxayna leedahay saameyn yar.Horraantii 1970-meeyadii, SAME waxa loo isticmaali jiray daawoyinka la qoro ee arthritis-ka Yurub.Sannadkii 1999kii, US FDA waxay ogolaatay SAME inuu yahay badeecad caafimaad waxayna noqotay mid ka mid ah alaabta nafaqada ee ugu iibinta badan gudaha Maraykanka.
S-Adenosyl-L-Methionine waxaa inta badan lagu diyaariyaa isku-dhafka kiimikada, halsano iyo isbeddelka enzymatic.Habka halsano ayaa ah in lagu daro horudhaca L-Methionine dhexdhexaadinta aasaasiga ah ee ka kooban ilaha C iyo N, iyo xaddi badan oo S-Adenosylmethionine ah ayaa lagu heli karaa iyadoo la abuurayo unugyada microbial.Tani hadda waa jidka ugu weyn ee wax soo saarka warshadaha ee S-Adenosylmethionine.Waxaa ka mid ah, microorganisms-ka loo isticmaalo halsano waxaa lagu heli karaa baaritaanka ama dib-u-habaynta hababka dhismaha, kuwaas oo lagu duubay maqaallo badan iyo shatiyo gudaha iyo dibaddaba.Daraasadaha qaarkood waxay bixiyeen habka diyaarinta ee S-adenosylmethionine, iyadoo la adeegsanayo polyhydroxy reagents organic si loo ilaaliyo dhaqdhaqaaqa enzyme, iyadoo la adeegsanayo adenosine triphosphate precursor, L-Methionine iyo fosfate ions sida substrates, glucose ama / iyo maltose sida deeq-bixiyeyaasha tamarta, ku daraya halabuurka ee ions birta ah, iyo iyadoo la isticmaalayo cadaadis wax soo saarka daadi kara si ay u kiciyaan wax soo saarka ee S-Adenosylmethionine ee unugyada oo dhan.Isticmaalka ka kooban ions biraha si loo habeeyo socodka dheef-shiid kiimikaadka si loo hagaajiyo tamarta is-ku-xidhka hufnaanta, ku daray reagents organic si loo ilaaliyo dhaqdhaqaaqa bakteeriyada iyo ensaymes, iyadoo la isticmaalayo cadaadis wax soo saarka permeable si ay u diyaariyaan S-Adenosylmethionine, gaabin waqtiga synthesis, iyo ka dhig badeecada meel ka baxsan unugga, taas oo badbaadin karta qiimaha kala-soocidda dambe oo fududayn karta tallaabooyinka hawlgalka.
Macluumaadka ku saabsan badbaadada muddada-dheer ee S-Adenosyl-L-Methionine waa xaddidan tahay sababtoo ah ka-qaybgalayaasha daraasadaha intooda badan waxay ku qaateen kaliya waqti gaaban.Si kastaba ha ahaatee, hal daraasad oo ku saabsan cudurka beerka ee khamriga, kaqeybgalayaashu waxay qaateen S-Adenosyl-L-methionine 2 sano;Daraasadaas, wax saameyn ah oo halis ah lama soo sheegin.
Dadka qaba xanuunka laba-cirifoodka (cudurka lagu garto isbeddelka niyadda, laga bilaabo niyad-jabka ilaa waallida) waa inaysan u qaadan SAME calaamadaha niyad-jabka ah marka laga reebo kormeerka bixiyaha xanaanada caafimaadka sababtoo ah SAME waxay ka sii dari kartaa calaamadaha waallida.
In kasta oo S-Adenosyl-L-Methionine loo isticmaalay daawaynta cholestasis-ka xilliga uurka, ammaankeeda xilliga uurka lama xaqiijin.
SAME waxa laga yaabaa inay hoos u dhigto saamaynta levodopa (L-dopa), daawada loo isticmaalo daawaynta cudurka Parkinson.Waxa kale oo suurtogal ah in SAME ay la falgasho daroogooyinka iyo kaabisyada cuntada ee kordhiya heerarka serotonin (kiimiko ay soo saaraan unugyada dareemayaasha), sida antidepressants, L-tryptophan, iyo St. John's wort.
Waxaa jira walaac aragtiyeed oo ku saabsan isticmaalka SAME ee dadka difaaca jirran (sida kuwa qaba HIV).Dadka difaaca jirkoodu liito waxay halis ugu jiraan infekshanka Pneumocystis carinii, iyo SAME waxay kor u qaadaysaa korriinka microorganism-ka.
Dhibaatooyinka ay keento SAME waa wax aan caadi ahayn, marka ay dhacaanna waxay badanaa yihiin dhibaatooyin yaryar sida lallabbo ama calool-xanuun.
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