Afatinib Dimaleate CAS 850140-73-7 Purity>99.5% (HPLC) API

Afatinib Dimaleate (CAS: 850140-73-7), qaabka milixda dimaleate ee afanitib, waa wakiilka antineoplastic ee afka laga helo.Afatinib Dimaleate waa horjooge qoyska EGFR ah oo aan la beddeli karin oo leh IC50s ee 0.5 nM, 0.4 nM, 10 nM iyo 14 nM ee EGFRwt, EGFRL858R, EGFRL858R/T790M iyo HER2, siday u kala horreeyaan.Afatinib Dimaleate waxaa lagu tilmaamaa daawaynta safka kowaad ee bukaanada qaba kansarka sambabada unugyada aan yarayn ee metastatic (NSCLC) kuwaas oo burooyinkooda ay leeyihiin unugyada koritaanka epidermal factor reseptor (EGFR) exon 19 tirtirka ama exon 21 (L858R) beddelka beddelka sida ay ogaatay FDA- imtixaan la ansixiyay.Waagii hore, daawaynta caadiga ah ee daaweynta kimoterabi-ku-salaysan ee platinum-ku-salaysan ayaa loo qaddariyay daawaynta safka koowaad ee caadiga ah ee dhammaan bukaannada qaba NSCLC.Si kastaba ha ahaatee, caddaymaha soo baxaya ayaa aqoonsaday dad-hoosaadyo kuwaas oo daawaynta la beegsaday ay aad waxtar u leedahay, taasoo horseedaysa horumarinta daawooyinka is-beddelka gaarka ah.Afatinib Dimaleate waxa soo saaray Boehringer Ingelheim Pharmaceuticals, Afatinib Dimaleate waxa ansixisay FDA sanadkii 2013 sidii daawo agoon ah oo hoos timaada magaca ganacsiga Gilotrif.Afatinib Dimaleate waxa lagu farsameeyay kiimiko ahaan iyadoo la isticmaalayo hababka caadiga ah.Afatiib Dimaleatema aha oo kaliya firfircoon ka soo horjeeda isbeddellada EGFR ee ay bartilmaameedsanayaan jiilka kowaad TKIs sida erlotinib ama gefitinib, laakiin sidoo kale ka soo horjeeda isbeddellada sida T790M kuwaas oo aan xasaasi u ahayn daaweyntan caadiga ah.Sababtoo ah waxqabadkeeda dheeraadka ah ee ka dhanka ah Her2, waxaa laga baarayaa kansarka naasaha iyo sidoo kale EGFR iyo kansarrada kale ee Her2.