Afatiib Dimaleate Intermediate CAS 314771-76-1 daahirnimo>99.0% (HPLC) Sawirka Warshada

Afatiib Dimaleate Intermediate CAS 314771-76-1 daahirnimo>99.0% (HPLC) Warshada

Sharaxaad Gaaban:

Magaca Kiimikada: (S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine

CAS: 314771-76-1

Daahirsanaanta:>99.0% (HPLC)

Muuqashada: Jaal fudud ilaa budada jaalaha ah

Dhexdhexaadiyaha Afatiib Dimaleate (CAS: 850140-73-7)

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Sharaxaad:

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Guryaha Kiimikada:

Magaca Kiimikada	(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-Diamine
La mid ah	N4-(3-Chloro-4-Fluorophenyl) -7-[[(3S)-Tetrahydro-3-Furanyl] oxy] -4,6-Quinazolinediamine;Afatilib wasakh B;Afatinib-des (4-Dimethylamino-2-en-1-oxo)butyl;Des(4-Dimethylamino-2-en-1-oxo)butyl Afatinib
Lambarka CAS	314771-76-1
Lambarka CAT	RF-PI2028
Heerka Saamiyada	Kaydka dhexdiisa, Awoodda Wax-soo-saarka 100MT/Sannadka
Qaanuunka molecular	C18H16ClFN4O2
Miisaanka Molecular	374.8
Barta Karsan	559.0±50.0℃
Cufnaanta	1.473 ± 0.060 g / cm3
Summada	Kiimikada Ruifu

Tilmaamaha:

Shayga	Tilmaamaha
Muuqashada	Jaalle fudud ilaa budada jaalaha ah
Aqoonsiga	Waqtiga Haynta ee Maamulaha Sare ee HPLC waa in uu la jaanqaadaa heerka
Daahirnimada / Habka Falanqaynta	>99.0% (HPLC)
Khasaare xagga qalajinta	<0.50%
Hadhaaga dabka	<0.20%
Xumaanta Keliya	<0.50%
Wadarta wasakhda	<1.00%
Biraha culus (sida Pb)	≤20pm
Heerka Imtixaanka	Heerka Ganacsiga
Isticmaalka	Dhexdhexaadiyaha Afatiib Dimaleate (CAS: 850140-73-7)

Xidhmada & Kaydinta:

Xidhmada: Dhalo, bacda bireed aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka

Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka

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FAQ:

Codsiga:

(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine (CAS: 314771-76-1) waa dhex dhexaad ka ah Afatinib Dimaleate (CAS: 850140-73-7).Afatinib waa jiilka labaad ee awoodda leh oo aan dib loo celin karin dual inhibitor of the epidermal factor factor reseptor (EGFR) iyo koritaanka epidermal factor receptor 2 (HER2) tyrosine kinase, horumariyo by Boehringer Ingelheim, Germany.Waxay awood u leedahay inay si aan leexleexad lahayn u joojiso dhaqdhaqaaqa tyrosine kinase iyada oo la marinayo falcelinta Michael ee kooxda thiol ee cysteine ee booska 797 ee EGFR.Shaqada: 1. Sida Lapatinib iyo Neratinib, Afatinib waa borotiinka kinase inhibitor kaas oo sidoo kale si aan leexleexad lahayn u xakameynaya kororka koritaanka epidermal ee bini'aadamka 2 (Her2) iyo receptor factor factor (EGFR) kinases.2. Afatinib kaliya ma aha mid ka soo horjeeda isbeddellada EGFR ee ay bartilmaameedsanayaan jiilka kowaad ee TKIs sida erlotinib ama gefitinib, laakiin sidoo kale ka soo horjeeda isbeddellada sida T790M kuwaas oo aan xasaasi u ahayn daaweynta caadiga ah.Sababtoo ah waxqabadkeeda dheeraadka ah ee ka dhanka ah Her2, waxaa laga baarayaa kansarka naasaha iyo sidoo kale EGFR iyo kansarrada kale ee Her2.3. Afatinib waa daawo loogu talagalay daawaynta safka kowaad ee bukaanada qaba noocyada kala duwan ee metastatic (EGFR mutation positive) kansarka sambabada unugyada yaryar (NSCLC).Waxay u shaqeysaa sidii is-hortaag aan la bedeli karin oo ka mid ah soo-dhoweeyaha tyrosine kinases epidermal growth factor reseptor (EGFR) iyo erbB-2 (HER2).