Afatiib Dimaleate Intermediate CAS 314771-88-5 daahirnimo>99.0% (HPLC) Warshada
Dhexdhexaadiyaha Keenida Kiimikada Ruifu ee Afatinib
Afatirib CAS 439081-18-2
Afatiib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino) acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-hal CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5
Magaca Kiimikada | (S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-Amine |
La mid ah | N- (3-Chloro-4-Fluorophenyl) -6-Nitro-7-[(3S) -oxolan-3-yl] oxyquinazolin-4-Amine;7-((S)-Tetrahydrofuran-3-yloxy) -4- (3-Chloro-4-Fluorophenyl) amino-6-Nitroquinazoline;Afatilib wasakhnimo |
Lambarka CAS | 314771-88-5 |
Lambarka CAT | RF-PI2027 |
Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
Qaanuunka molecular | C18H14ClFN4O4 |
Miisaanka Molecular | 404.78 |
Cufnaanta | 1.534± 0.060 g/cm3 |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Jaalle ilaa fudud budada jaalaha ah |
Daahirnimada / Habka Falanqaynta | >99.0% (HPLC) |
Khasaare xagga qalajinta | <0.50% |
Xumaanta Shaqsiga ah | <0.50% |
Wadarta wasakhda | <1.00% |
Biraha culus | ≤20pm |
Heerka Imtixaanka | Heerka Ganacsiga |
Isticmaalka | Dhexdhexaadiyaha Afatiib Dimaleate (CAS: 850140-73-7) |
Xidhmada: Dhalo, bacda bireed aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-Amine (CAS: 314771-88-5) ayaa loo isticmaalaa diyaarinta Afatiib Dimaleate (CAS: 850140-73-7).Afatinib waa dawo cusub oo lagula dagaalamo kansarka, waa jiil cusub oo ah daawada afka laga qaato, daawadii ugu horaysay ee la dagaalanka kansarka ee aduunka taas oo si aan kasoo noqosho lahayn ugu xidhan qoyska ErbB, aadna u waxtar badan oo la beegsaday Waxay xannibtaa calaamada kicisa koritaanka unugyada kansarka. , yaraynta ama dib u dhigista badinta unugyada kansarka.Afatinib waxay ka tirsan tahay koox dawooyin ah oo loo yaqaanno tyrosine kinase inhibitors.Waxay u shaqeysaa iyada oo xannibaysa shaqada laba borotiin oo isku dhow, soo-dhoweeyaha kobaca epidermal (EGFR) iyo receptor factor factor koritaanka epidermal 2 (HER2).Loo isticmaalo daawaynta safka kowaad ee bukaanada qaba kansarka sambabada unug yar-yar.Afatinib waa dawo cusub oo lagula dagaalamo kansarka, waa jiil cusub oo ah daawada afka laga qaato, daawadii ugu horaysay ee la dagaalanka kansarka ee aduunka taas oo si aan kasoo noqosho lahayn ugu xidhan qoyska ErbB, aadna u waxtar badan oo la beegsaday Waxay xannibtaa calaamada kicisa koritaanka unugyada kansarka. , yaraynta ama dib u dhigista badinta unugyada kansarka.