Anastrozole CAS 120511-73-1 Tayada Sare ee Warshada API
Soo saaraha soo saaraha oo leh nadiif sare iyo tayo xasilan
Magaca Kiimikada: Anastrozole
CAS: 120511-73-1
Magaca | Anastrozole |
La mid ah | Arimidex;α,α,α',α'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl) -1,3-benzenediacetonitrile |
Lambarka CAS | 120511-73-1 |
Lambarka CAT | RF-API74 |
Heerka Saamiyada | Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram |
Qaanuunka molecular | C17H19N5 |
Miisaanka Molecular | 293.37 |
Solubility | Ku milmay DMSO iyo ethanol |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Budada Crystalline ee Caddaan iyo Off-White |
Aqoonsiga A | IR/MS Waafaqsan heerka tixraaca |
Aqoonsiga B | HPLC iyo qaabka ugu sarreeya: Ku habboon tixraaca |
Meesha dhalaalaysa | 81.0 ~ 84.0 ℃ |
Waxyaalaha biyaha (waxaa qoray KF) | ≤0.30% |
Hadhaaga dabka | ≤0.10% |
Khasaare xagga qalajinta | ≤0.50% |
Biraha culus | ≤10pm |
Walxaha laxidhiidha | |
Xumaanta A | ≤0.10% |
Xumaanta B | ≤0.20% |
Xumaanta C | ≤0.20% |
Xumaanta D | ≤0.10% |
Xumaanta E | ≤0.10% |
Xumaan Kale Oo Keliya | ≤0.10% |
Wadarta wasakhda | ≤0.50% |
Xalalka Haraaga ah | |
Cyclohexane | ≤0.30% |
Ethyl acetate | ≤0.50% |
Qiimayn | 98.0% ~ 102.0% (ku salaysan qalalan) |
Nolosha shelf | 24 bilood |
Heerka Imtixaanka | Heerka Ganacsiga;USPharmacopoeia (USP) Heerka |
Isticmaalka | Daawaynta Kansarka Naasaha |
Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
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Anastrozole (CAS 120511-73-1), waa non-steroidal, jiilka saddexaad achiral triazole derivative suuqay sida ARIMIDEX® by AstraZeneca Pharmaceuticals LP1.Waa mid ka mid ah jiilka saddexaad ee aromatase inhibitor kaas oo ah mid aad u tartan badan oo xakameynaya aromatase, sidaas darteed xannibaya beddelka testosterone ee estradiol iyo androstenedione galay estrone.Joojinta enzyme aromatase waxay si gaar ah u dhacdaa iyada oo loo marayo tartanka tartanka aromatase ee kooxda hemegroup ee cytochrome P450, hoos u dhigista biosynthesis estrogen ee unugyada durugsan ee jirka iyo naaska.
Anastrozole waa daaweyn guud oo si wanaagsan loo dulqaatay oo loogu talagalay kansarka naasaha marxaladda hore.Sida kuwa kale ee aromatase inhibitors, saamaynta xun ee ugu muhiimsan waxay ahayd khatarta sii kordheysa ee jabka lafaha, taas oo loogu talagalay anastrozole waxay ku xaddidnayd muddada daaweynta.Waxay si gaar ah u leedahay sun khafiif ah marka la barbar dhigo kiimoterabiga;si kastaba ha ahaatee, waxaa la ogaaday in bukaanno badan oo lagu daaweeyay anastrozole ay ka cawdeen calaamadaha wadajirka ah intii la filayay, gaar ahaan qallafsanaanta dhijitaalka ah ee la mid ah kan rheumatoid arthritis-ka.Qaar ka mid ah tijaabooyinka bukaan-socodka ee anastrozole ee haweenka postmenopausal ee qaba kansarka naasaha ee Yurub iyo Maraykanka ayaa soo sheegay xanuunada muruqyada sida dhacdooyinka xun.Anastrozole (Arimidex®) waa inhibitor aromatase ah oo lagu ansixiyey Midowga Yurub, Maraykanka iyo dalalka kale ee adduunka oo dhan si loogu isticmaalo daawaynta adjuvant ee haweenka postmenopausal ee leh marxalad hore, hormoon receptor-hormoon kansarka naasaha.Waxa kale oo laga oggolaaday Midowga Yurub iyo waddamo kale oo adduunka ah sii wadida daawaynta adjuvant ee haweenka hore u lahaa 2-3 sano ee daawaynta tamoxifen adjuvant ee kansarka naasaha.
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