Apixaban CAS 503612-47-3 daahirnimo ≥99.5% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. waa saaraha ugu horreeya ee Apixaban (CAS: 503612-47-3) oo leh tayo sare leh.Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibso Apixaban,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | Apixaban |
| La mid ah | 1- (4-Methoxyphenyl) -7-oxo-6-[4- (2-oxopiperidin-1-yl) phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c] pyridine -3-carboxamide, 4,5,6,7-Tetrahydro-1- (4-methoxyphenyl) -7-oxo-6-[4- (2-oxo-1-piperidinyl) phenyl]-1H-pyrazolo[3, 4-c]pyridine-3-carboxamide, BMS 562247, BMS-562247 |
| Heerka Saamiyada | Suuqa dhexdiisa, Wax-soo-saarka Ganacsiga |
| Lambarka CAS | 503612-47-3 |
| Qaanuunka molecular | C25H25N5O4 |
| Miisaanka Molecular | 459.51 g/mol |
| Meesha dhalaalaysa | 235.0 ~ 238.0 ℃ |
| Cufnaanta | 1.42 |
| COA & MSDS | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Qaybta | API |
| Summada | Kiimikada Ruifu |
| Walxaha | Heerarka Kormeerka | Natiijooyinka |
| Muuqashada | Budada Crystalline ee Caddaan iyo Off-White | U hogaansama |
| Khasaare xagga qalajinta | ≤0.50% | 0.10% |
| Hadhaaga dabka | ≤0.10% | 0.08% |
| Biraha culus (sida Pb) | ≤20pm | U hogaansama |
| Walxaha laxidhiidha | ||
| Xumaan Keli ah | ≤0.50% | U hogaansama |
| Wadarta wasakhda | ≤0.50% | U hogaansama |
| Daahirnimada / Habka Falanqaynta | ≥99.5% (HPLC) | 99.9% |
| Infrared Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| 1 H NMR Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| Gabagabo | Alaabta waa la tijaabiyay oo waafaqay qeexitaannada | |
Xidhmada:Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
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Suuqyada Waaweyn?Iibiya suuqa gudaha, Waqooyiga Ameerika, Yurub, Hindiya, Kuuriya, Jabbaan, Australia, iwm.
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Apixaban (CAS: 503612-47-3) waa nooc cusub oo daawada xinjirowga lidka ku ah afka ee ay sameeyeen Bristol Myers Squibb iyo Pfizer.Waa nooc cusub oo afka ah Xa factor inhibitor, magaceeduna ganacsi waa Eliquis.Apixaban waxaa loo isticmaalaa in lagu daaweeyo bukaanada qaangaarka ah ee lagu sameeyo qalliinka beddelka miskaha ama jilibka si looga hortago xinjirowga xididka (VTE)
Apixaban (CAS: 503612-47-3) waa afka laga soo xushay firfircoonida Xa factor inhibitor wuxuuna ka hortagi karaa jiilka thrombin iyo thrombosis.
Apixaban (CAS: 503612-47-3) waa daawada xinjirowga lidka ku ah afka saddexaad ee saddexaad ee iibka ah, ka dib dabigatran iyo rivaroxaban, waxaana horey loogu ansixiyay Yurub si looga hortago xinjirowga xididdada xididdada dhiigga ee bukaanada maraya qaliinka beddelka miskaha ama jilibka.Saddexdan xinjirowga lidka ku ah afka ee lagu ansixiyey Yurub, marka la barbar dhigo daawaynta caadiga ah ee ka hortagga ah ee ka hortagga xinjirowga xididada xididada, enoxaparin, rivaroxaban ayaa ku fiicnaaday tijaabada rikoodhada, iyo apixaban ayaa ku fiicnaaday tijaabada hore.Saamaynta daawaynta ee Rivaroxaban ayaa xoogaa sare u kacday, laakiin waxay keentay dhiigbax ka daran kan apixaban.Cilmi-baadhayaashu waxay u sababeeyeen kala duwanaanshahan wakhtiga daawaynta, maadaama rivaroxaban la qaatay 6-8 saacadood qalliinka ka dib tijaabada rikoodhada, halka apixaban la isticmaalay 18 saacadood ka dib qaliinka tijaabada hore.Daawooyinkani waxay leeyihiin saameyn bogsiineed oo wanaagsan marka loo isticmaalo meel u dhow wakhtiga qalliinka, laakiin sidoo kale waxay leeyihiin khatarta dhiig-baxa oo kordhay.Cilmi-baaris caafimaad ayaa muujisay in marka la barbardhigo cirbadeynta maalinlaha ah ee 40mg enoxaparin, 2 qiyaasta 2.5mg ee afka ee apixaban waxay leedahay saameyn ka hortag ah oo ka hortagga xididdada xididdada dhiigga ka dib qalliinka beddelka sinta ama jilibka mana kordhin khatarta dhiig-baxa.
Apixaban (CAS: 503612-47-3) waa nooc cusub oo afka ah Xa factor inhibitor oo ay si wadajir ah u soo saareen Bristol-Myers Squibb iyo Pfizer.Magaca ganacsiga waa eratol, oo ah nooc cusub oo ah daawada xinjirowga lidka ku ah afka.Iyadoo la joojinayo xinjirowga muhiimka ah ee Xa, apixaban waxay ka hortagi kartaa soo saarista thrombin iyo xinjirowga dhiigga.Bishii Abriil 26, 2007, Bristol-Myers Squibb waxay ku biirtay gacmaha Pfizer si ay ugu dhawaaqdo iskaashiga horumarinta apixaban cusub ee daawada xinjirowga lidka ku ah afka oo ay leedahay Bristol-Myers Squibb iyada oo beddelka warfarin la cusboonaysiiyay.Sida ku cad heshiiska iskaashiga, Pfizer waxay bixin doontaa lacag horudhac ah oo US $ 0.25 bilyan ah Bristol-Myers Squibb si ay u qaadato 60% ee kharashka horumarinta xinjirowga lidka ku ah apixaban (oo la hirgelinayo Janaayo 1, 2007), halka Bristol-Myers Squibb wuxuu qaadi doonaa inta soo hartay 40%, si uu u helo xuquuqda wadajirka ah ee horumarinta iyo iibinta daawada.Bishii Maajo 2011, apixaban ayaa ahayd tii ugu horreysay ee oggolaatay ka hortagga xinjirowga dhiigga ee bukaannada qaangaarka ah ee lagu sameynayo qalliinka beddelka misigta ama jilibka ee 27 dalalka EU, Iceland iyo Norway.Bishii Nofeembar 20, 2012, Guddiga Yurub ayaa ansixiyay Ererto (apixaban) si looga hortago istaroogga iyo embolism nidaamka ee bukaannada qaangaarka ah ee qaba fibrillation-ka aan-valvular atrial (NVAF) oo leh hal ama dhowr arrimood oo halis ah.Ka dib, Maamulka Cuntada iyo Dawooyinka ee Kanadiyaanka, Japan, iyo US FDA ayaa ansixiyay Ererto?(apixaban) ee ka hortagga istaroogga iyo embolism-ka nidaamka ee bukaannada qaangaarka ah ee qaba fibrillation-ka aan valvular ahayn (NVAF) oo leh hal ama dhowr arrimood oo halis ah.Abriil 12, 2013, dawada cusub ee xinjirowga lidka ku ah ee Eloto (ELIQUIS)(apixaban) oo ay si wadajir ah u sameeyeen Bristol-Myers Squibb iyo Pfizer ayaa si rasmi ah loogu dhawaaqay in lagu taxay Shiinaha.Ererto waa cunsur cusub oo afka laga qaato Xa inhibitor oo loogu talagalay ka hortagga xinjirowga dhiigga xididada (VTE) ee bukaannada qaangaarka ah ee lagu beddelayo sinta ama jilibka ee la doortay.Liiskeedu wuxuu bixiyaa doorasho cusub oo badbaado leh oo waxtar leh oo loogu talagalay xinjirowga lidka ku ah bukaan-socodka ka dib qalliinka lafaha, waxayna u keentaa war wanaagsan bukaannada Shiinaha ee maraya beddelka miskaha/jilibka.Daraasadaha caafimaadku waxay xaqiijiyeen in marka la barbardhigo 40mg enoxaparin hal mar maalintii, 2 jeer maalintii maamulka afka ee eratol?(apixaban) 2.5mg ayaa aad waxtar ugu leh ka hortagga xinjirowga dhiigga ee xididdada dhiigga ka dib qalliinka beddelka sinta ama jilibka, mana kordhinayso khatarta dhiig-baxa.Jaantuska 1 wuxuu muujinayaa kaniiniyada Elotoapixaban ee ay soo saareen Bristol-Myers Squibb iyo Pfizer.
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