Argatroban CAS 74863-84-6 API Warshada Nadiifinta Sare ee Dhiig-xinjirowga
Dhexdhexaadiyeyaasha la xidhiidha saadka saaraha Argatroban:
Ethyl (2R,4R)-4-Methyl-2-Piperidinecarboxylate CAS 74892-82-3
N-Nitro-1,2,3,4-tetradehydro Argatroban Ethyl Ester CAS 74874-09-2
3-Methyl-8-Quinolinesulphonyl Chloride CAS 74863-82-4
Argatroban Monohydrate CAS 141396-28-3
Argatroban Anhydrous CAS 74863-84-6
| Magaca Kiimikada | Argatroban |
| La mid ah | Argatroban Anhydrous |
| Lambarka CAS | 74863-84-6 |
| Lambarka CAT | RF-API67 |
| Heerka Saamiyada | Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram |
| Qaanuunka molecular | C23H36N6O5S |
| Miisaanka Molecular | 508.63 |
| Meesha dhalaalaysa | 188.0 ~ 189.0 ℃ |
| Barta Karsan | 801.3ºC at 760 mmHg |
| Cufnaanta | 1.47 g/cm3 |
| Xaalada Maraakiibta | Lagu soo raray Heer kulka jawiga |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Budada Crystalline ee Caddaan iyo Off-White |
| Aqoonsiga HPLC | Waqtiga haynta ee mabda'a ugu sarreeya ee laga helay xalka Tijaabada wuxuu waafaqsan yahay kan laga helay xalalka caadiga ah, sida tijaabada Assay |
| Aqoonsiga IR | Waafaqsan IR Spectrum ee AG RS |
| Aqoonsiga UV | 259nm iyo 332nm meesha dhererka mawjada waa inay lahaadaan nuugista ugu badan |
| Biyo | 2.5-4.5% |
| Midabka Xalka & Cadaynta | Xalku waa inuu noqdaa Midab cad |
| La Xidhiidh Walxaha | |
| wasakhda A + wasakhda H | ≤0.10% |
| Xumaanta B | ≤0.10% |
| wasakhda C + wasakhda E | ≤0.10% |
| Xumaanta D | ≤0.10% |
| Xumaanta I | ≤0.10% |
| Bach of Nijaasta Aan La cayimin | ≤0.10% |
| Wadarta wasakhda | ≤0.30% |
| Xalalka Haraaga ah | |
| Methanol | ≤3000pm |
| Ethanol | ≤5000ppm |
| Dichloromethane | ≤600pm |
| Ethyl acetate | ≤5000ppm |
| Enantiomer (HPLC) | ≤0.10% |
| Saamiga Isomer (HPLC) | 30.0% -40.0% |
| Chloride | ≤0.01% |
| Hadhaaga dabka | ≤0.10% |
| Biraha culus | ≤10pm |
| Bakteeriyada Endotoxins | <5EU/mg |
| Xadka Microbial | TAMC ≤1000 cfu/g |
| Qiimayn | 98.0% -102.0% (oo ku salaysan anhydrous) |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | API, Synthetic Antithrombotic Agent Anti xinjirowga lidka ku ah |
Xidhmada: Dhalo, Bac aluminium biil ah, Durbaan kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
Shanghai Ruifu Chemical Co., Ltd. waa soo saaraha iyo soo saaraha ugu horreeya ee Argatroban (CAS: 74863-84-6) oo leh tayo sare, API.
Argatroban (CAS: 74863-84-6) waa wakiilka antithrombotic synthetic cusub oo waxtar u leh dayactirka ka hortagga xinjirowga lidka ku ah iyaga oo ischaemic stroke iyo faafiyay xinjirowga intravascular.Waa daawada xinjirowga lidka ku ah oo ah molecule yar oo toos ah xannibaadaha thrombin.Sannadkii 2000, argatroban waxa shati ka siisay Maamulka Cuntada iyo Dawooyinka (FDA) ka hortagga ama daawaynta xinjirowga bukaanka qaba heparin-induced thrombocytopenia (HIT).Sannadkii 2002, waxaa la oggolaaday in la isticmaalo inta lagu guda jiro waxqabadyada xididdada xididdada dhiigga ee bukaannada qaba HIT ama khatarta ugu jira inay yeeshaan.Sannadkii 2012, waxa ay MHRA ee UK u ansixisay ka-hortagga xinjirowga lidka ku ah bukaannada qaba heparin-induced thrombocytopenia Nooca II (HIT) kuwaas oo u baahan daawaynta antithrombotic parenteral.
