Aripiprazole CAS 129722-12-9 daahirnimo>99.0% (HPLC) API
Soo saaraha Dhexdhexaadiyaha Aripiprazole oo leh daahir sare
Aripiprazole API CAS 129722-12-9
1- (2,3-Dichlorophenyl)piperazine Hydrochloride CAS 119532-26-2
7-Hydroxy-3,4-Dihydro-2(1H)-Quinolinone CAS 22246-18-0
7-(4-Bromobutoxy)-3,4-Dihydro-2(1H)-Quinolinone CAS 129722-34-5
| Magaca Kiimikada | Aripiprazole |
| La mid ah | 7-[4-[4-(2,3-Dichlorophenyl)-1-Piperazinyl]butoxy]-3,4-Dihydro-2(1H)-Quinolinone |
| Lambarka CAS | 129722-12-9 |
| Lambarka CAT | RF-PI2270 |
| Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
| Qaanuunka molecular | C23H27Cl2N3O2 |
| Miisaanka Molecular | 448.39 |
| Solubility | Ku milmayn Biyaha;Aan lagu milmi karin Methanol |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Caddaan ama ku dhawaad cad budada crystalline |
| Aqoonsiga | By IR;By HPLC |
| Solubility | Ku milmay Acid Asiidh, Waxoogaa Ku Soluble Ethanol |
| Meesha dhalaalaysa | 136.0 ~ 140.0 ℃ |
| Khasaare xagga qalajinta | <0.50% |
| Hadhaaga dabka | <0.10% |
| Biraha culus | ≤20pm |
| Xalalka Haraaga ah | |
| Ethanol | ≤1000ppm |
| DMF | ≤200pm |
| Walxaha laxidhiidha | |
| Xumaan Keli ah | <0.20% |
| Wadarta wasakhda | <1.00% |
| Daahirnimada / Habka Falanqaynta | >99.0% (HPLC) |
| Qiimayn | 98.0% ~ 102.0% (oo ku salaysan Anhydrous) |
| Xadka yar | |
| Wadarta tirada Microbial Aerobic | ≤1000 cfu/g |
| Khamiirka iyo caaryada isku dhafan | ≤100 cfu/g |
| E·Coli | Maqnaanshaha |
| Abaabulka cudur-sidaha | Maqnaanshaha |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | API;Anti-psychotic |
Xidhmada: Dhalo, 5kg/Aluminium Aluminium, 25kg/ Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka
Aripiprazole (CAS: 129722-12-9) waa nooc cusub oo ka mid ah derivatives quinoline lipid aadka u lipid, saameynteeda dawooyinka sifo waa in aysan ahayn kaliya postsynaptic dopamine D2 antagonist, laakiin sidoo kale presynaptic dopamine D2 receptor agonist, waxay sidoo kale kartaa. kiciya D1, D3, D4 reseptors.Aripiprazole waa jiil labaad oo ah antipsychotic atypical antipsychotic iyo anti-depressant oo leh qayb ka mid ah firfircoonida agonist ee dopamine D2 iyo serotonin 5-HT1A reseptors iyo waxqabadka antagonist ee serotonin 5-HT2A reseptors.Qiimaha Ki waa 0.34 nM, 0.8 nM, 1.7 nM, iyo 3.4 nM, siday u kala horreeyaan, ee dopamine D2 iyo D3, serotonin 5-HT1A iyo 5-HT2A.Aripiprazole waxaa loo isticmaalaa daawaynta schizophrenia iyo xanuunada nafsiga ah ee la xidhiidha.Bristol-Myers Squibb iyo Otsuka Pharmaceutical Company ayaa ku dhawaaqay in Midowga Yurub uu ogolaaday Abilify (Aripiprazole) daaweynta codsiga liiska shisoofrani.Schizophrenia waxay saamaysaa 1% dadweynaha adduunka, iyo in ka badan oo ku dhaca da'yarta.Schizophrenia waxay saamaysaa fikirka, xakamaynta shucuureed iyo kartida go'aan qaadashada bukaanka.Bukaannada qaba cudurka dhimirka ee schizophrenia waxay yeelan doonaan calaamado ay ka mid yihiin dhalanteed iyo dhalanteed, bukaannada qaba calaamadaha xun waa ka-bax bulsho, la'aanta isbeddellada niyadeed.Sannadkii 2002 FDA waxay ogolaatay Abilify daawaynta schizophrenia, kaas oo leh shan awoodood oo qiyaas ah: 5 mg, 10 mg, 15 mg, 20 mg iyo 30 mg, tan iyo markii la ansixiyay.
