Atazanavir CAS 198904-31-3 Nadiifnimada ≥99.0% API Warshada Kahortagga HIV-ga HIV-1

Atazanavir (CAS 198904-31-3) waa antiretroviral, sheeko cusub iyo dawada azapeptide xoogga leh ee fasalka protease inhibitor (PI).Waxaa lagu iibiyaa magaca ganacsiga Reyataz.Sida antiretrovirals kale, waxaa loo isticmaalaa in lagu daweeyo caabuqa fayraska difaaca jidhka bini'aadamka nooca 1 (HIV-1) protease enzyme leh xannibaad joogto ah Ki of 66 nmol/L iyo sidoo kale waxay joojisaa taranka fayraska ee HIV-1 oo leh 50% fiirsashada waxtarka leh EC50 2.6 ilaa 5.3 nmol/L.Atazanavir waxay ku xidhan tahay HIV-1 protease ka hortagga dillaaca gag iyo gag-pol polyproteins, taas oo keenta samaynta virions aan qaan-gaarin ee unugyada HIV-1.Atazanavir waxay leedahay qaab-dhismeedka kiimikaad ee C-2 oo kala duwan iyo guud ahaan awoodda ka hortagga retroviral ee noocyada kala duwan ee HIV marka la barbar dhigo kuwa kale ee xannibaya borotiinka, oo ay ku jiraan Indinavir, Nelfinavir, Ritonavir, Saquinavir iyo Amprenavir.Atazanavir waxaa laga soocaa PI-yada kale in la siin karo hal mar maalintii oo ay saameyn yar ku yeelato astaanta dufanka ee bukaanka.Sida kuwa kale ee ka hortagga protease, waxa loo isticmaalaa oo keliya marka lagu daro dawooyinka kale ee HIV.Atazanavir waa novel azapeptide HIV protease inhibitor.Ka hortagga fayraska.Waxaa afka laga qaadaa hal mar maalintii.