Bacitracin Zinc CAS 1405-89-6 Awoodda ≥70 IU/mg Warshada Antibiyootiga ee Peptide
Shanghai Ruifu Chemical Co., Ltd. waa saaraha iyo soo saaraha ugu horreeya ee Bacitracin Zinc (Zinc Bacitracin) (CAS: 1405-89-6) oo leh tayo sare leh.Waxaan bixin karnaa COA, gaarsiinta adduunka oo dhan, tiro yar iyo tiro badan oo la heli karo.Haddii aad xiisaynayso Bacitracin Zinc (Zinc Bacitracin),Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | Bacitracin Zinc |
| La mid ah | Bacitracin Zinc Salt;Zinc Bacitracin |
| Heerka Saamiyada | Kaydka dhexdiisa, Awoodda Wax-soo-saarka 10 Tan sannadkii |
| Lambarka CAS | 1405-89-6 |
| Qaanuunka molecular | C66H101N17O16SZn |
| Miisaanka Molecular | 1486.07 |
| Meesha dhalaalaysa | 250 ℃ (diseembar) |
| Biyuhu milmayn | 5.1 g/L |
| COA & MSDS | La heli karo |
| Tusaale | La heli karo |
| Summada | Kiimikada Ruifu |
| Walxaha | Tilmaamaha | Natiijooyinka |
| Muuqashada | Cadaan ama iftiin jaale-cawlan ama budada beige | waafaqsan |
| Aqoonsiga | Buuxi Shuruudaha | U Muuqda Falcelin Wanaagsan |
| pH | 6.0 ~ 7.5 | 7.1 |
| Khasaare xagga qalajinta | ≤5.0% | 2.7% |
| Zinc ( walxo la qalajiyey) | 4.0% ~ 6.0% | 4.20% |
| Awoodda | ≥70 IU/mg Imtixaanka Microbial Assay (Asal qallalan) | 71 IU/mg |
| Waxyaabaha ay ka kooban tahay Bacitracin A | ≥40.0% | 58.2% |
| Waxa ku jira Bacitracin firfircoon | ≥70.0% (Bacitracin A, B1, B2, iyo B3) | 86.1% |
| Xadka Hore ee Peptides Eluting | ≤20.0% | 7.6% |
| Xaddidaadda Bacitracin F | ≤6.0% | 1.1% |
| Wadarta tirada hawada ee la hirgalin karo | <100 CFU/gram | waafaqsan |
| Gabagabo | Alaabtu waxay u hoggaansamaysaa heerarka USP44 | |
| Isticmaalka ugu weyn | Antibiyootiga Peptide | |
Xidhmada:Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Weelka si adag u xidh oo ku kaydi qabow, qalalan (2 ~ 8 ℃) iyo bakhaar hawo wanaagsan leh oo ka fog walxaha aan ku habboonayn.Ka ilaali iftiinka iyo qoyaanka.
Rarida:Ku gaarsii adduunka oo dhan hawo, by FedEx/DHL Express.Bixi keenid degdeg ah oo la isku halayn karo.
Bacitracins, kakan zinc.
Bacitracins zinc complex [1405-89-6].
» Bacitracin Zinc waa isku-dhafka zinc ee bacitracin, oo ka kooban isku-dar ah polypeptides antimicrobial, qaybaha ugu muhiimsan waa bacitracins A, B1, B2, iyo B3.Waxay leedahay awood aan ka yarayn 65 Unugyada Bacitracin halkii mg, oo lagu xisaabiyo sal qallalan.Waxay ka kooban tahay wax aan ka yarayn 4.0 boqolkiiba oo aan ka badnayn 6.0 boqolkiiba zinc (Zn), oo lagu xisaabiyo saldhigga qallalan.
Baakadaha iyo kaydinta- Ku kaydi weelal cidhiidhi ah, oo ku kaydi meel qabow.
Calaamadee-ku calaamadee si aad u muujiso in loo isticmaalo samaynta daawooyinka aan waalid ahayn oo keliya.Halka lagu baakadeeyey isku-darka daawada, ku calaamadee si aad u muujiso in aanay nadiif ahayn iyo in awoodda aan la hubin karin in ka badan 60 maalmood ka dib marka la furo, iyo si aad u sheeg tirada unugyada Bacitracin halkii milligram.Meesha loogu talagalay in loogu isticmaalo diyaarinta foomamka qiyaasta qiyaasta nadiifka ah, calaamaddu waxay sheegaysaa in ay nadiif tahay ama ay tahay in lagu sameeyo habayn dheeraad ah inta lagu jiro diyaarinta foomamka qiyaasta qiyaasta nadiifka ah.
Heerarka Tixraaca USP <11>-
USP Bacitracin Zinc RS
Aqoonsiga -
A: Tijaabada Aqoonsiga Chromatographic ee khafiifka ah <201BNP>: buuxiyey shuruudaha.
B: Waxay buuxisay shuruudaha nidaamka chromatographic dareeraha ee tijaabada Halabuurka.
Madhalaysnimada <71>-Halka ay calaamaddu ku sheegayso inay nadiif tahay, waxay buuxinaysaa shuruudaha marka la tijaabiyo sida lagu faray sifaynta Membrane ee hoos timaada Tijaabada Madhalaysnimada Alaabta si loo baadho, marka laga reebo isticmaalka dareeraha A ee L kasta oo lagu daray 20 g ee disodium edetate.
pH <791>: inta u dhaxaysa 6.0 iyo 7.5, ee xal (qanaysan) oo ka kooban ku dhawaad 100 mg halkii ml.
Luminta qalajinta <731>-Ku qallaji qiyaastii 100 mg dhalada daboolka daboolan ee vacuum 60 ilaa 3 saacadood: waxay luminaysaa wax aan ka badnayn 5.0% miisaankeeda.
Waxyaalaha Zinc- [xusuus-Diyaar garowga caadiga ah iyo diyaarinta Tijaabada waxaa laga yaabaa in tiro ahaan lagu qasi karo 0.001 N hydrochloric acid, haddii loo baahdo, si loo helo xalalka fiirsashada ku habboon, la qabsan kara toosan ama kala duwanaanta shaqada ee qalabka.]
Diyaargarowga caadiga ah-Ku wareeji 3.11 g oo ah zinc oxide, si sax ah loo miisaamay, ilaa 250-mL weel mug leh, ku dar 80 mL ee 1 N hydrochloric acid, diirran si ay u milaan, qabow, ku milmaan biyo mugga, iyo qas.Xalkani wuxuu ka kooban yahay 10 mg oo zinc ah halkii ml.Ku sii dar xalkan 0.001 N hydrochloric acid si aad u hesho diyaargarowga caadiga ah ee ka kooban 0.5, 1.5, iyo 2.5 µg of zinc per mL, siday u kala horreeyaan.
Diyaarinta Tijaabada-Ku wareeji qiyaastii 200 mg oo Zinc Bacitracin ah, oo si sax ah loo miisaamay, kuna wareeji weel mug leh oo 100-ml ah.Ku milmi 0.01 N hydrochloric acid, ku mil isla dareere la mid ah mugga, oo qas.Dhuumaha 2 mL ee xalkan ku shub weel mug leh oo 200-mL ah, ku mil 0.001 N hydrochloric acid si mug ah, oo isku qas.
Habka-Si isku mid ah u go'aami nuugista diyaarinta Heerka iyo diyaarinta Tijaabada ee xariiqda resonance zinc ee 213.8 nm, oo leh spectrophotometer nuugista atomiga ku habboon (eeg Spectrophotometry iyo Iftiin-kala-firdhinta <851>), oo ku qalabaysan nalka zinc godan-cathode iyo olol hawo-acetylene, oo isticmaalaya 0.001 N hydrochloric acid sida bannaan.Qoree nuugista istaandarka iyo fiirsashada, µg halkii ml, ee zinc, oo sawir xariiq toosan oo ku habboon saddexda dhibcood ee la qorsheeyay.Laga soo bilaabo garaafka sidaas la helay, go'aami fiirsashada, µg halkii ml, ee zinc ee diyaarinta Imtixaanka.Xisaabi waxa ku jira zinc, boqolkiiba, qaybta Bacitracin Zinc ee ay qaadatay caanaha:
1000C / W
kaas oo C ay ku jirto µg halkii ml, ee zinc ee diyaarinta Imtixaanka;iyo W waa miisaanka, mg, qaybta Bacitracin Zinc ee la qaatay.
Halabuurka-
Buffer- Ku mil 34.8 g oo ah phosphate potassium, dibasic, 1 L oo biyo ah.Ku hagaaji 27.2 g oo ah phosphate potassium, monobasic, ku milmay 1 L oo biyo ah, pH ah 6.0.
Wajiga guurguura- Diyaari isku dhafka methanol, biyo, kayd, iyo acetonitrile (26:15:5:2).Si fiican isku qas, iyo degas.
Dareemka-Mila 40 g oo ah disodium edetate 1 L oo biyo ah.Ku hagaajiso sodium hydroxide ku milmi pH ah 7.0.
Xalka ku habboonaanta nidaamka-Ku milmi tirada saxda ah ee la miisaamay ee USP Bacitracin Zinc RS gudaha Diluent si aad u hesho xal leh qiyaas magac ahaan ah oo ku saabsan 2.0 mg halkii ml.
Soo gudbinta xadka xadka-Ku qas tiro ahaan, biyo, mugga ku habboon ee xalka ku habboon nidaamka si loo helo xal la og yahay oo ah 0.01 mg halkii ml.
Xalka aqoonsiga ugu sarreeya-Ku milmaan cadad la miisaamay oo USP Bacitracin Zinc RS ah mug ku habboon oo Diluent ah si loo helo xal ururin magaceedu yahay 2.0 mg halkii ml.Kuleyli biyaha qubeyska ee karkaraya 30 daqiiqo.Ku qabow heerkulka qolka.
Tijaabada xalka-Ku milmi qadar saxan oo la miisaamay oo ah Bacitracin Zinc gudaha Diluent si aad u hesho xal leh qiyaas magac ahaan ah oo ah 2.0 mg halkii ml.
Nadaamka Chromatographic (eeg Chromatography <621>)-Kromaatograph-ka dareeraha ah waxa uu ku qalabaysan yahay qalabka wax-nuugista iyo 4.6- × 250-mm tiir dhamaadka-kooban oo ka kooban 5-µm xirmo L1.Heerka socodka waa 1.0 mL daqiiqadii.Deji dhererka hirarka baaraha 300 nm.Ku duri ilaa 100 µL ee xalka aqoonsiga Peak, oo cadee meesha ay ku jirto bacitracin F, taas oo ah wasakh la yaqaan, adoo isticmaalaya wakhtiga haynta ee ku cad shaxda 1.
Shaxda 1
Magaca Qaybaha Waqtiga Haynta Qaraabo (qiyaastii)
Bacitracin C1 0.5
Bacitracin C2 0.6
Bacitracin C3 0.6
Bacitracin B1 0.7
Bacitracin B2 0.7
Bacitracin B3 0.8
Bacitracin A 1.0
Bacitracin F 2.4
Beddel dhererka hirarka baaraha oo dhig 254 nm.Chromatograph oo ah xalka ku habboonaanta nidaamka, oo qor jawaabaha ugu sarreeya sida lagu faray Habraaca: aqoonso meelaha ugu sarreeya ee qaybaha ugu firfircoon ee bacitracin (bacitracins A, B1, B2 iyo B3), peptides hore u soo baxaysa (kuwa ka soo baxaya ka hor heerka ugu sarreeya sababtoo ah bacitracin B1 iyo wasakhda, bacitracin F, iyadoo la isticmaalayo qiimaha wakhtiga haynta qaraabo ah ee lagu sheegay shaxda 1. Xisaabi saamiga ugu sarreeya ilaa dooxada adoo isticmaalaya qaacidada:
Hp / HV
kaas oo Hp uu yahay dhererka ka sarreeya saldhigga ugu sarreeya sababtoo ah bacitracin B1;iyo HV waa dhererka ka sarreeya saldhigga ugu hooseeya ee qalooca kala sooca bacitracin B1 ee ugu sarreeya sababtoo ah bacitracin B2.Saamiga ugu sarreeya ee dooxada kama yara 1.2.
Habka-Si gooni ah u duri mugga siman (100 µL) ee dareeraha, xalka tijaabada, iyo ka warbixinta xalalka xadka.Ku duub chromatogram-yada ilaa saddex jeer wakhtiga haynta ee bacitracin A. Aqoonso meelaha ugu sarreeya adiga oo isticmaalaya wakhtiyada haynta qaraabada ah ee ku cad shaxda 1. Cabir meelaha ugu sarreeya ee dhammaan meelaha ugu sarreeya ee xalka Tijaabada.[Xusuusin- Iska daa wax kasta oo ugu sarreeya ee xalka Tijaabada isagoo leh aag ka yar aagga bacitracin-ka A ugu sarreysa ee xalka warbixinta;iska daa wax kasta oo ugu sarreeya ee lagu arkay Diluent.]
note-Guud ahaan aagga xisaabinta soo socota waxaa lagu qeexaa inay tahay bedka dhammaan meelaha ugu sarreeya marka laga reebo heerka warbixinta.
waxa ku jira bacitracin a- Xisaabi boqolkiiba bacitracin A adoo isticmaalaya caanaha:
(rA / Wadarta bedka) × 100
taas oo rA ay tahay jawaabta aagga bacitracin A. Bacitracin A waxa ku jira aan ka yarayn 40.0% wadarta aagga.
Waxa ku jira bacitracin firfircoon- Xisaabi boqolkiiba bacitracin firfircoon (bacitracin A, B1, B2, iyo B3) adoo isticmaalaya qaaciddada:
(rA + rB1 + rB2 + rB3 / aagga guud)×100
kuwaas oo rA, rB1, rB2, iyo rB3 ay yihiin jawaabaha aagga ee bacitracin A, B1, B2, iyo B3, siday u kala horreeyaan.Wadarta bacitracin A, B1, B2, iyo B3 kama yara 70.0% wadarta aagga.
Xadka hore ee peptides-ka- xisaabi boqolkiiba dhammaan meelaha ugu sarreeya ee sarreeya ka hor inta aan la gaarin heerka ugu sarreeya sababtoo ah bacitracin B1 adoo isticmaalaya caanaha:
(rPreB1 / wadarta aagga) ×100
taas oo rPreB1 ay tahay wadarta jawaabaha dhammaan meelaha ugu sarreeya ee ka soo baxaya ka hor inta aan la gaarin heerka ugu sarreeya ee bacitracin B1.Xadka hore ee peptides (kuwa ka soo baxa ka hor inta aan la gaarin heerka ugu sarreeya sababtoo ah bacitracin B1) kama badna 20.0%.
xadka bacitracin f- Xisaabi boqolkiiba bacitracin F adoo isticmaalaya caanaha:
100 × (rF / rA)
taas oo rF ay tahay jawaabta bacitracin F ee xalka tijaabada;iyo rA waa jawaabta bacitracin A ee xalka tijaabada.Xadka bacitracin F, wasakh la og yahay, kama badna 6.0%.
Imtixaan-ku-sii wad Bacitracin Zinc sida lagu faray hoosta Antibiyootigyada-Baadhitaannada Microbial 81.
Sidee loo Iibsadaa?Fadlan la xidhiidhDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Bacitracin waxaa laga soosaaraa xalalka dhaqameed ee lichen (Bacillus licheniformis) waana antibiyootig polypeptide ah.Caddaan ama budo huruud ah oo fudud, aan ur lahayn ama wax yar ur, dhadhan qadhaadh, hygroscopic.Si fudud ugu milmay biyaha iyo ethanol, aan degganayn, xalalka aqueous si fudud ayaa loo dami karaa heerkulka qolka, aan degganayn pH 9, waana in lagu qaboojiyaa qaboojiyaha ka dib kala diri.Alaabtan waxaa loo xisaabiyaa sidii alaab qalalan, iyo titer halkii milligram waa inuusan ka yarayn 55 unug bacitracin.Bacitracin zinc waa bacitracin zinc milixda, taas oo ka xasilloon marka loo eego bacitracin.Waxa loo istcimaalaa sida wax lagu daro quudin waxayna leedahay hawlo kor u qaadida koritaanka iyo kobcinta xoolaha iyo digaaga, ka hortagga caabuqa mindhicirka, iyo kordhinta gunnada quudinta.Qiyaasta waxay la mid tahay bacitracin.Bacitracin bakteeriyada spectrum waxay la mid tahay penicillin, taas oo saameyn xooggan ku leh bakteeriyada gram-positive oo aan wax saameyn ah ku yeelan bakteeriyada garaam-negative.Caabuqyada daran ee Staphylococcus aureus u adkaysta daawada.Maamulka afka lama nuugo waxaana loo isticmaalaa caabuqa mindhicirka.Isticmaalka dibadda ayaa sidoo kale waxtar u leh oogada jirka, caabuqa afka iyo indhaha iyo naaso ay keento bakteeriyada xasaasiga ah.Waxay saameyn xun ku leedahay kelyaha.Bacitracin zinc ayaa loo isticmaalay sida daroogo quudin ah.Maamulka afka ayaa ah mid si dhib leh loo nuugo, sidaa darteed waxaa guud ahaan la rumeysan yahay in aysan jirin wax dhibaato ah oo haraaga daroogada ah ee xoolaha iyo wax soo saarka digaaga.Alaabtani waa antibiyootig cidhiidhi ah, kaas oo saameyn xoog leh ku leh bakteeriyada garaam-positive.Waxa kale oo ay wax ku ool u tahay spirochetes iyo actinomycetes, laakiin waa wax aan waxtar lahayn bakteeriyada gram-negative.Waxay leedahay saamayn synergistic leh noocyo kala duwan oo antibiyootik ah sida penicillin G, streptomycin, neomycin, polymyxin, iwm. Its cusbada zinc waxaa inta badan loo isticmaalaa sida lagu daro feed, kaas oo uu leeyahay hawlaha ka hortagga caabuqa mindhicirka, kor u koritaanka iyo hagaajinta quudinta.Bakteeriyadu waxay si tartiib tartiib ah u yeelan kartaa caabbinta alaabtan, laakiin ma jiraan wax iska caabin ah oo u dhexeeya alaabtan iyo antibiyootiga kale.Alaabtani aad bay sun u tahay lamana duri karoWaxa afka laga qaadan karaa in lagu daweeyo shubanka bakteeriyada ee xoolaha iyo Treponema dysentery ee doofaarka.Kiliinik ahaan, waxaa inta badan loo isticmaalaa in lagu daro noocyo kala duwan oo antibiyootik ah sida penicillin, streptomycin, neomycin, polymyxin B, iwm si kor loogu qaado waxtarka.
Bacitracin Zinc waa kakan ay sameeyeen bacitracin iyo ion zinc.waa antibiyootiga polypeptide waana antibiyootiga loogu isticmaalka badan yahay wakhtigan xaadirka ah.Maadada zinc guud ahaan waa 2% ~ 12%.Alaabooyinka synthetic waa budo cad ama huruud ah, oo leh ur gaar ah, oo ay fududahay in lagu milmo walxaha alkaline ee daciifka ah, si fududna ugu milma biyaha, methanol iyo ethanol.Bacitracin zinc waxay leedahay saameyn bakteeriyada bakteeriyada gram-positive, sidoo kale waxay leedahay sifooyin bakteeriyada ka hortagga bakteeriyada Gram-negative.Isticmaalka zinc bacitracin ee quudinta qiimaha buuxa ee doofaarku waxay kor u qaadi kartaa heerka koritaanka, hagaajinta gunnada quudinta, iyo ka hortagga shubanka bakteeriyada doofaarka iyo cudurrada neef-mareenka ee joogtada ah.Isku-darka isku-darka guud ahaan waa 10 ~ 100mg / kg, saameyntuna si weyn uma wanaajin wax ka baxsan qiyaasta dheeraadka ah.Bacitracin Zinc guud ahaan laguma nuugo mindhicirrada doofaarka, markaa ma jirto dhibaato haraaga ah.Waa maaddo antibiyootik ah oo ammaan ah oo la isku halayn karo.Bacitracin Zinc waa sun aad u daran oo aan si sahal ah u nuugin mindhicirka, sidaa darteed looma isticmaali karo daawaynta caabuqyada nidaamka.
Antibiyootigyada polypeptide-ka waxay saameyn xooggan ku leeyihiin bakteeriyada bakteeriyada garaam-positive, waxayna sidoo kale saameyn bakteeriyada ku leedahay dhowr bakteeriyada garaam-negative, spirochetes, actinomycetes iyo xitaa penicillin-u adkaysta staphylococci.Habka bakteeriyada waa in la joojiyo samaynta gidaarka unugyada bakteeriyada oo ay dhaawacdo xuubka unugyada bakteeriyada.Waxay kor u qaadi kartaa koritaanka microorganisms faa'iido leh ee xiidmaha, waxay kordhisaa qulqulka xuubabka mindhicirka, waxayna kor u qaadaa nuugista nafaqooyinka.Inta badan waxaa loo isticmaalaa si kor loogu qaado koritaanka xoolaha iyo digaagga, ka hortagga iyo xakamaynta shuban bakteeriyada ee xoolaha iyo digaagga iyo dhiig-dhiig-dhiig qaba ee uu keeno Treponema.Bacitracin Zinc si dhib ah ayay u nuugtaa gudaha, badankeedana waxaa laga soo saaraa saxarada 2 maalmood gudahood, sidaas darteed ma fududa in lagu sii jiro xoolaha iyo wax soo saarka digaagga;Bakteeriyadu dhif ayay u samaysaa iska caabbinta bacitracin, mana laha iska caabbinta antibiyootiga kale, waxayna leedahay saamayn is-dhexgal ah oo leh penicillin, streptomycin, neomycin, aureomycin, polymyxin, iwm. Alaabtani aad bay sun u tahay lamana duri karo.Alaabtan waxaa ka mamnuuc ah olaquindox, kitasamycin, virginiamycin, iyo Enramycin.
Sida wax lagu daro quudinta, waxaa inta badan loo isticmaalaa si kor loogu qaado koritaanka xoolaha iyo digaagga, ka hortagga shuban bakteeriyada ee xoolaha iyo digaagga iyo dhiig- dysentery uu keeno treponema.Bacitracin Zinc si dhib ah ayay u nuugtaa gudaha, badankeedana waxaa laga soo saaraa saxarada 2 maalmood gudahood, sidaas darteed ma fududa in lagu sii jiro xoolaha iyo wax soo saarka digaagga;Bakteeriyadu dhif ayay u samaysaa iska caabbinta bacitracin, mana laha iska caabbinta antibiyootiga kale, waxayna leedahay saamayn is-dhexgal ah oo leh penicillin, streptomycin, neomycin, aureomycin, polymyxin, iwm. Alaabtani aad bay sun u tahay lamana duri karo.Alaabtan waxaa ka mamnuuc ah olaquindox, kitasamycin, virginiamycin, iyo Enramycin.
Bacitracin Zinc waa antibiyootiko polypeptide ah, kaas oo saameyn bakteeriya ku leh bakteeriyada garaam-positive.Nidaamkeedu inta badan waa in la xakameeyo isku-darka gidaarka bakteeriyada ee bakteeriyada, sidoo kale waxay isku dari kartaa xuubka unugyada bakteeriyada xasaasiga ah, waxay dhaawacdaa daacadnimada xuubka unugyada, waxayna keentaa soo-baxa walxaha muhiimka ah ee unugyada.Si wax ku ool ah u joojiso bakteeriyada Gram-positive iyo qaar ka mid ah bakteeriyada Gram-negative;heerka caabbinta bakteeriyada ee zinc bacitracin waa mid gaabis ah, mana jiraan wax iska caabbinta antibiyootiga kale.Antibiyootikada polypeptide waxay joojisaa dephosphorylation of pyrophosphate lipid, sidaas awgeed waxay joojisaa isku-darka derbiyada unugyada bakteeriyada.
