Betamethasone CAS 378-44-9 Nadiifinta 97.0% ~ 103.0% API Nadaafadda Sare

Betamethasone
C22 H29FO5 392.46
Uurka-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11,16)-.
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione [378-44-9].
Betamethasone waxay ka kooban tahay wax aan ka yarayn 97.0 boqolkiiba oo aan ka badnayn 103.0 boqolkiiba C22H29FO5, oo lagu xisaabiyo sal qallalan.
Baakadaha iyo kaydinta-Ku xafid weel cidhiidhi ah.Ku kaydi inta u dhaxaysa 2℃ iyo 30℃.
Heerarka Tixraaca USP <11>-
USP Betamethasone RS
Aqoonsiga -
J: Nuugista Infrared <197M>.
B: Tijaabada Aqoonsiga Chromatographic-Layer ee khafiifka ah <201>-
Tijaabi xalka-U diyaari xal Betamethasone ee khamriga fuuqbaxay oo ka kooban 0.5 mg halkii mL.
Horumarinta habka dareeraha: isku dhafka chloroform iyo diethylamine (2:1).
Habka-u soco sida lagu faray cutubka, marka laga reebo in la helo dhibcooyinka adiga oo si khafiif ah ugu buufinaya aashitada sulfuric acid (1 ee 2) iyo kuleylinta saxan kulul ama hoos laambad ilaa ay baro ka muuqdaan.
Wareeg gaar ah <781S>: inta u dhaxaysa +118 iyo +126, oo lagu xisaabiyay saldhigga qallalan.
Xalka tijaabada: 5 mg halkii ml, methanol.
Luminta qalajinta 731-ku qalaji 105 ilaa 3 saacadood: waxay luminaysaa wax aan ka badnayn 1.0% miisaankeeda.
Hadhaaga dabka 281: aan ka badnayn 0.2%, platinum crucible ayaa la isticmaalayaa.
wasakhda caadiga ah 466-
Xalka tijaabada: methanol.
Xalka caadiga ah: methanol.
Codsiga mugga: 10µL.
Eluant: isku dar ah toluene, acetone, methyl ethyl ketone, iyo formic acid (55:20:20:5), oo ku jira qol aan dheellitirnayn.
Muuqaalka: 5.
Imtixaan-
Marxaladda guurguura- Diyaari isku dhafka biyaha iyo acetonitrile la sifeeyay oo la soo dejiyay (63:37).Samee hagaajin haddii loo baahdo (eeg Habboonaanta Nidaamka ee hoos timaada Chromatography 621).
Xalka caadiga ah ee gudaha-U diyaari xalka propylparaben ee aalkolada iyadoo la og yahay in la og yahay oo ku saabsan 0.25 mg halkii ml.
U diyaargarowga caadiga ah-Mila tirada saxda ah ee USP Betamethasone RS ee aalkolada si loo helo xal la og yahay oo ku saabsan 0.2 mg halkii ml.Ku wareeji 10.0 ml ee xalkan fijaal ku habboon, kuna dar 10.0 ml oo ah xal gudaha gudaha ah, si aad u hesho diyaargarow heerar ah oo la og yahay oo ku saabsan 0.1 mg oo betamethasone ah iyo qiyaastii 0.125 mg propylparaben halkii ml.
Diyaarinta Assay-Isticmaalka qiyaastii 80 mg ee Betamethasone, si sax ah loo miisaamay, u diyaari sidii lagu faray diyaarinta caadiga ah.
Nadaamka Chromatographic (eeg Chromatography 621)-Kromaatograph-ka dareeraha ah waxa uu ku qalabaysan yahay 240-nm detector iyo tiir 4.6-mm × 25-cm ah oo ka kooban xirmo L1.Heerka socodka waa qiyaastii 1.0 mL daqiiqadii.Chromatograph ee heerka diyaarinta, oo qor jawaabaha ugu sarreeya sida lagu faray Habraaca: waqtiyada haynta qaraabo waxay ku dhow yihiin 1.0 ee betamethasone iyo 1.4 ee propylparaben;xallinta, R, inta u dhaxaysa betamethasone iyo propylparaben kama yarayn 3.0;iyo weecasho heerka qaraabo ah ee cirbadaha soo noqnoqda kama badna 2.0%.
Habka-Si gooni ah u duri mugga siman (qiyaastii 10 µL) ee diyaarinta Heerka iyo diyaarinta Assay chromatograph-ka, duub chromatogram-yada, oo cabbir jawaabaha meelaha ugu sarreeya.Xisaabi tirada, mg, ee C22H29FO5 ee qaybta Betamethasone ee ay qaadatay qaacidada:
800C (RU / RS)
taas oo C ay tahay xoojinta, mg per mL, ee USP Betamethasone RS ee diyaarinta Standard;iyo RU iyo RS waa saamiga ugu sarreeya ee dhererka betamethasone iyo heerka ugu sarreeya ee gudaha ee laga helay diyaarinta Assay iyo diyaarinta Heerka, siday u kala horreeyaan.