Bicalutamide CAS 90357-06-5 API Tayada Sare ee Kansarka Qanjidhka Prostate Sawirka

Bicalutamide CAS 90357-06-5 API Kansarka Prostate Sare oo Tayo Sare leh

Sharaxaad Gaaban:

Magaca: Bicalutamide

CAS: 90357-06-5

Muuqashada: Caddaan ilaa-cad-cad budada crystalline

Qiimaynta: 98.0% ~ 102.0%

Bicalutamide ee daaweynta kansarka qanjirka 'prostate' ee sare

API Tayada Sare, Wax soo saarka Ganacsiga

Inquiry: alvin@ruifuchem.com

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Sharaxaad:

Soo saaraha soo saaraha oo leh nadiif sare iyo tayo xasilan
Magaca: Bicalutamide
CAS: 90357-06-5
Bicalutamide ee daaweynta kansarka qanjirka 'prostate' ee sare
API Tayada Sare, Wax soo saarka Ganacsiga

Guryaha Kiimikada:

Magaca	Bicalutamide
La mid ah	N-[4-Cyano-3- (trifluoromethyl) phenyl]-3-[(4-fluorophenyl) sulfonyl]-2-hydroxy-2-methylpropionamide
Lambarka CAS	90357-06-5
Lambarka CAT	RF-API76
Heerka Saamiyada	Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram
Qaanuunka molecular	C18H14F4N2O4S
Miisaanka Molecular	430.37
Heerkulka Kaydinta	2-8℃
Summada	Kiimikada Ruifu

Tilmaamaha:

Shayga	Tilmaamaha
Muuqashada	Budada Crystalline ee Caddaan iyo Off-White
Aqoonsiga A	IR: Spectrum muunadu waxay u dhigantaa heerka tixraaca
Aqoonsiga B	HPLC: Waqtiga haynta ee ugu sarreysa xalka muunada waxay u dhigantaa tan xalka caadiga ah
Aqoonsiga C	Aqoonsiga Fluoride-ka Dabiiciga ah
Solubility	Si Xor Ah Ugu Soluble Acetone iyo Tetrahydrofuran, Waxyar Ku Soluble Ethyl Acetate
Meesha dhalaalaysa	191.0-195.0 ℃
Waxyaalaha biyaha (waxaa qoray KF)	≤0.20%
Waxa ku jira fluoride	15.9% ~ 18.5%
Khasaare xagga qalajinta	≤0.50%
Hadhaaga dabka	≤0.10%
Biraha culus	≤10pm
Xalalka Haraaga ah
Tetrahydrofuran	≤0.072%
Toluene	≤0.089%
N-Hexane	≤0.029%
Acetone	≤0.50%
Ethyl acetate	≤0.50%
Walxaha laxidhiidha
N, N'-Dimethyl Acetamide	≤0.109%
Bicalutamide Aminobenzonitrile	≤0.10%
Isku-dhafka Bicalutamide La Xiriira A Isomer A	≤0.10%
Isku-dhafka Bicalutamide La Xiriira A Isomer B	≤0.10%
Desfluoro Bicalutamide	≤0.20%
2-Fluoro Bicalutamide	≤0.20%
Deoxy Bicalutamide	≤0.20%
Bicalutamide Sulfide	≤0.10%
Najaasad kasta oo aan la cayimin	≤0.10%
Wadarta wasakhda	≤0.50%
Cabbirka Qaybaha	90% <10um;50% <5um
Qiimayn	98.0% ~ 102.0% (ku salaysan qalalan)
Tijaabooyinka Microbiological
Wadarta tirada hawada ee la hirgalin karo	≤500CFU/g
Khamiir iyo caaryaal	≤50CFU/g
Nolosha shelf	24 bilood
Heerka Imtixaanka	Heerka Ganacsiga;Heerka USP
Isticmaalka	API, ee daaweynta Kansarka qanjirka 'prostate' ee sare

Xidhmada & Kaydinta:

Xidhmada: Dhalo, boorsada aluminium aluminium, durbaanka kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.

Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.

Faa'iidooyinka:

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Codsiga:

Bicalutamide (CAS: 90357-06-5) waa antagonist aan steroidal ahayn, kaas oo la tartamaya soo-dhoweynta androgen-ka ee androgen-ka, xannibaya qaadashada gacanta ee androgen, oo xannibaysa ku-xidhka androgens ee xubinta la beegsanayo.Waxay ku xidhan tahay reseptor-ka androgen-ka kaas oo sameeya isku-xidhka reseptor-ka, kaas oo galaa xudunta oo lagu daro nukleoprotein-ka, taas oo ka hortagaysa koritaanka unugyada burooyinka.Waxay noqon kartaa sida dawada safka kowaad ee daawaynta palliative ee kansarka qanjirka 'prostate'.Bicalutamide waxaa laga bilaabay Boqortooyada Ingiriiska, oo ah suuqgeedii ugu horreeyay ee adduunka oo dhan, oo loogu talagalay daawaynta kansarka qanjirka 'prostate' ee horumarsan oo ay weheliso analoogga LHRH ama qalliin.A non-steroidal, antiandrogen peripherally xushay, bicalutamide xannibi tallaabada dihydrotestosterone iyo testosterone ee goobaha bartilmaameedka by tartanka ku xidha cytosolic androgen receptor ah.Waxaa lagu soo waramayaa in si fiican loo dulqaatay iyada oo aan lahayn waxyeelooyinka wadnaha iyo xididada dheef-shiid kiimikaadka sababtoo ah faa'iidada la'aanta wax dhaqdhaqaaq steroid ah.Waxtarka bicalutamide sida monotherapy ahaan ayaa lagu muujiyay kiliinikada.Heerarka jawaabta rajo-gelinta leh ayaa sidoo kale laga soo sheegay daawaynta mindhicirka, naaska, beeryarada iyo kansarka sambabada unugyada aan yaryarayn.