Bortezomib CAS 179324-69-7 Nadiifinta ≥99.0% (HPLC) API Nadaafadda Sare ee Warshada
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Bortezomib CAS 179324-69-7
| Magaca Kiimikada | Bortezomib |
| La mid ah | Velcade, MG-341, PS-341 |
| Lambarka CAS | 179324-69-7 |
| Lambarka CAT | RF-API65 |
| Heerka Saamiyada | Kaydka, Miisaanka Wax-soo-saarka Ilaa boqollaal Kiilogaram |
| Qaanuunka molecular | C19H25BN4O4 |
| Miisaanka Molecular | 384.24 |
| Meesha dhalaalaysa | 122.0 ~ 124.0 ℃ |
| Cufnaanta | 1.214 |
| Tusmada Dib-u-celinta | 1.564 |
| Solubility | Ku milma Chloroform, DMSO, ethanol iyo methanol |
| Xasilooni | Higroscopic iyo Qoyaanka xasaasiga ah |
| Xaalada Maraakiibta | Lagu soo raray Heer kulka jawiga |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Budada cad ama Off-Cad |
| Daahirnimada / Habka Falanqaynta | ≥99.0% (HPLC) |
| Khasaare xagga qalajinta | ≤0.50% |
| Hadhaaga dabka | ≤0.20% |
| Wareegga indhaha | -41.0° ~ -46.0° |
| Birta culus | ≤20pm |
| Aysiidhka | 4.0 ~ 7.0 |
| Isomer | ≤0.50% |
| Xumaanta Keliya | ≤0.50% |
| Wadarta wasakhda | ≤1.0% |
| Xalalka Haraaga ah | |
| Methanol | ≤0.30% |
| Dichloromethane | ≤0.05% |
| Hexane | ≤0.02% |
| Ethyl acetate | ≤0.50% |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | API |
Xidhmada: Dhalo, Bac aluminium biil ah, Durbaan kartoonada, 25kg/Drum, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka, qoyaanka iyo cayayaanka.
Shanghai Ruifu Chemical Co., Ltd. waa saaraha iyo soo saaraha ugu horreeya ee Bortezomib (CAS: 179324-69-7) oo leh tayo sare, API.
Bortezomib, oo lagu iibiyo magaca sumadda Velcade iyo kuwa kale, waa dawo ka hortagga kansarka oo loo isticmaalo in lagu daweeyo myeloma badan iyo lymphoma unugga mantle.Bortezomib waxaa loo oggolaaday isticmaalka caafimaadka gudaha Mareykanka 2003 iyo Midowga Yurub 2004. Waxay ku jirtaa Liiska Dawooyinka Muhiimka ah ee Ururka Caafimaadka Adduunka.Bortezomib waa ka hortagga borotiinka ugu horreeya ee loo oggolaado FDA-da Mareykanka ee Multiple myeloma, kansarka dhiigga.Dib-u-dejiyaha la beddeli karo ee 26S proteasome-qayb-protein-badane qaabeysan oo foosto ah oo laga helay xudunta iyo cytosol ee dhammaan unugyada eukaryotic.Bortezomib waa xushay oo adag 26S proteasome inhibitor, kaas oo ah boronic acid dipeptide derivative.Daraasadaha unugyada kansarka qanjidhada ee bini'aadamka waxay muujinayaan Bortezomib si loo xakameeyo PKR-like endoplasmic reticulum (ER) kinase oo kor u qaado cadaadiska ER, taasoo keenta apoptosis.
