Candesartan Cilexetil CAS 145040-37-5 daahirnimo>99.0% (HPLC) Sawirka Warshada API

Candesartan Cilexetil CAS 145040-37-5 daahirnimo>99.0% (HPLC) Warshada API

Sharaxaad Gaaban:

Magaca Kiimikada: Candesartan Cilexetil

CAS: 145040-37-5

Daahirsanaanta:>99.0% (HPLC)

Muuqashada: Caddaan ilaa-cad-cad budada crystalline

Xulashada Angiotensin II Receptor antagonist

API Tayada Sare, Wax soo saarka Ganacsiga

E-Mail: alvin@ruifuchem.com

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Sharaxaad:

Qalabka Kiimikada ee Ruifu Candesartan Cilexetil Dhexdhexaad oo leh daahir sare
Candesartan Cilexetil CAS 145040-37-5
Candesartan CAS 139481-59-7
1-Chloroethyl Cyclohexyl Carbonate CAS 99464-83-2
Candesartan Cilexetil Dhexdhexaad Eethyl Ester C6 CAS 139481-41-7
Candesartan Cilexetil Dhexdhexaadiyaha CAS 139481-44-0
Tril Candesartan Cilexetil CAS 170791-09-0

Guryaha Kiimikada:

Magaca Kiimikada	Candesartan Cilexetil
La mid ah	TCV-116;1-((((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl) -2-ethoxy-1H -benzo[d]imidazole-7-Carboxylate
Lambarka CAS	145040-37-5
Lambarka CAT	RF-PI1891
Heerka Saamiyada	Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan
Qaanuunka molecular	C33H34N6O6
Miisaanka Molecular	610.66
Summada	Kiimikada Ruifu

Tilmaamaha:

Shayga	Tilmaamaha
Muuqashada	Budada Crystalline ee Caddaan iyo Off-White
Aqoonsiga HPLC	Waqtiga haynta ee ugu sarreysa chromatogram-ka muunadda ayaa u dhiganta tan chromatogram-ka laga helay heerka
Aqoonsiga IR	IR nuugista infrared spectrum waxay la mid tahay heerka tixraaca Candesartan Cilexetil
Cadaynta iyo Xalka Midabka	Xalka chloroform ee 5% waa cad yahay oo aan midab lahayn
Daahirnimada / Habka Falanqaynta	>99.0% (HPLC)
Meesha dhalaalaysa	155.0 ~ 160.0 ℃
Khasaare xagga qalajinta	<0.30%
Hadhaaga dabka	<0.10%
Biraha culus	<10pm
Arsenic (As)	<1pm
Qaybinta Cabbirka Qaybaha	90% <30 μm
Waxyeellada dabiiciga ah	by HPLC
Ethyl Candesartan	<0.15%
Desethyl Candesartan	<0.15%
N2-Ethyl Candesartan Cilexei	<0.15%
Wax kasta oo wasakh ah oo aan la garanayn	<0.15%
Wadarta wasakhda	<0.60%
Qiimaynta Potentiometry	99.0 ~ 101.0% ee C33H34N6O6, lagu xisaabiyay walaxda anhydrous
Dabiiciga Dabiiciga ah
Methano	<0.30%
Ethanol	<0.50%
Diethyl Ether	<0.50%
Aceton	<0.50%
Dichloromethan	<0.06%
Dimethylformamide	<0.088%
Fadhitaanka Microbiological
Wadarta tirada Microbial Aerobic	<1000cfu/g
Caaryada & khamiirka	<100cfu/g
E.Coli	Maqan
Salmonella	Maqan
Heerka Imtixaanka	Heerka Ganacsiga
Isticmaalka	API;Wakiilka Dhiig-karka

Xidhmada & Kaydinta:

Xidhmada: Dhalo, bacda bireed aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka

Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka

Faa'iidooyinka:

FAQ:

Codsiga:

Candesartan Cilexetil (TCV-116) (CAS: 145040-37-5) waa angiotensin II reseptor antagonist leh IC50 ee 0.26 nM, oo loo isticmaalo daaweynta hypertension.Candesartan waa angiotensin-receptor blocker (ARB) kaas oo laga yaabo in loo isticmaalo kaligiis ama wakiilada kale si loo daaweeyo hypertension.Waxaa loo maamulaa afka sida prodrug, candesartan cilexetil, kaas oo si degdeg ah loogu beddelay metabolite firfircoon, candesartan, inta lagu jiro nuugista ee mareenka caloosha iyo mindhicirka.Candesartan waxay hoos u dhigtaa cadaadiska dhiigga iyadoo ka soo horjeeda nidaamka renin-angiotensin-aldosterone (RAAS);waxay la tartantaa angiotensin II si loogu xidho nooca-1 angiotensin II reseptor (AT1) subtype waxayna ka hortagtaa cadaadiska dhiigga ee sii kordhaya saamaynta angiotensin II.Si ka duwan angiotensin-converting enzyme (ACE) horjoogayaasha, ARBs ma laha saamaynta xun ee qufaca qalalan.Candesartan ayaa laga yaabaa in loo isticmaalo daawaynta dhiig-karka, hypertension systolic go'doonsan, hypertrophy ventricular bidix iyo nephropathy sonkorowga.Waxa kale oo loo isticmaali karaa sidii wakiil kale oo loogu talagalay daawaynta wadne xanuunka, cillad la'aanta systolic, wadnaxanuun myocardial iyo cudurrada halbowlaha wadnaha.