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Carvedilol CAS 72956-09-03 daahirnimo>99.0% (HPLC) Sawirka
  • Carvedilol CAS 72956-09-03 daahirnimo>99.0% (HPLC)

Carvedilol CAS 72956-09-03 daahirnimo>99.0% (HPLC)

Sharaxaad Gaaban:

Magaca Kiimikada: Carvedilol

CAS: 72956-09-03

Daahirsanaanta:>99.0% (HPLC)

Muuqaalka: Budada Crystalline White

Xiriirka: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Faahfaahinta Alaabta

Alaabooyinka La Xiriira

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Sharaxaad:

Shanghai Ruifu Chemical Co., Ltd. waa saaraha ugu horreeya ee Carvedilol (CAS: 72956-09-03) oo leh tayo sare leh.Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibso Carvedilol,Please contact: alvin@ruifuchem.com

Dhexdhexaadiyayaasha la xidhiidha:

Dhexdhexaadiyaha laxiriira ee Carvedilol

Guryaha Kiimikada:

Magaca Kiimikada Carvedilol
La mid ah 1- (9H-Carbazol-4-yloxy) -3-[[2- (2-Methoxyphenoxy) ethyl] amino]-2-Propanol;Fanaanka;Cadillan;Carca;Wadnaha;Carloc;Carvas;Carvedilol;Carvediol;Coreg;DQ 2466;Dilatrend;Dimitone;Eukardic;Korvasan;Kredex;Querto;Talliton;BM-14190
Heerka Saamiyada Suuqa dhexdiisa, GMP Commercial
Lambarka CAS 72956-09-3
Qaanuunka molecular C24H26N2O4
Miisaanka Molecular 406.48 g/mol
Meesha dhalaalaysa 115.0 ilaa 119.0 ℃
Cufnaanta 1.250± 0.06 g/cm3
Ku milmay biyaha Aan ku milmin Biyaha
Solubility Ku milma Methanol.Waxoogaa Ku Soluble Ethanol, Ether
Heerkulka Kaydinta Meel Qabow & Qallalan (2 ~ 8 ℃)
COA & MSDS La heli karo
Summada Kiimikada Ruifu

Tilmaamaha:

Walxaha Heerarka Kormeerka Natiijooyinka
Muuqashada Budada Crystalline White U hogaansama
Khasaare xagga qalajinta ≤0.50% (105 ℃ 3 saac) 0.25%
Hadhaaga dabka ≤0.10% 0.07%
Walxaha laxidhiidha    
Wadarta wasakhda ≤0.50% U hogaansama
Xumaanta A ≤0.20% U hogaansama
Xumaanta C ≤0.02% U hogaansama
Wax kasta oo kale oo aan nadiif ahayn ≤0.10% U hogaansama
Biraha culus (Pb) ≤10pm <10pm
Daahirnimada / Habka Falanqaynta >99.0% (HPLC) 99.72%
Infrared Spectrum Waafaqsan Qaab-dhismeedka U hogaansama
Gabagabo Alaabta waa la tijaabiyay oo waafaqay qeexitaannada

Xidhmada/Kaydinta/Raridda:

Xidhmada:Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Ku kaydi weel si adag u xiran.Ku kaydi bakhaar qabow, qalalan (2 ~ 8 ℃) iyo bakhaar hawo wanaagsan leh oo ka fog walxaha aan ku habboonayn.Ka ilaali iftiinka iyo qoyaanka.
Rarida:Ku gaarsii adduunka oo dhan hawo, by FedEx/DHL Express.Bixi keenid degdeg ah oo la isku halayn karo.

Faa'iidooyinka:

Awood ku filan: Tas-hiilaad ku filan iyo farsamoyaqaanno

Adeegga Xirfadlaha: Adeegga iibsashada hal joogsi

Xidhmada OEM: Xidhmada gaarka ah iyo summada ayaa diyaar ah

Gaadhida Degdega ah: Haddii kaydku ku jiro, dammaanad bixinta saddex maalmood ah

Supply xasiloon: Hayso kayd macquul ah

Taageerada Farsamada: Xalka tignoolajiyada waa la heli karaa

Adeegga Isku-dhafka Gaarka ah: Wuxuu u dhexeeyaa garaam ilaa kiilo

Tayo Sare: Waxaa la sameeyay nidaam hubinta tayada dhamaystiran

FAQ:

Sidee loo Iibsadaa?Fadlan la xidhiidhDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

Khibrad 15 Sano ah?Waxaan leenahay in ka badan 15 sano oo waayo-aragnimo ah oo ku saabsan soo saarista iyo dhoofinta ee tiro balaadhan oo ah dhexdhexaad ah daawooyinka tayada sare leh ama kiimikooyinka ganaax.

Suuqyada Waaweyn?Iibiya suuqa gudaha, Waqooyiga Ameerika, Yurub, Hindiya, Kuuriya, Jabbaan, Australia, iwm.

Faa'iidooyinka?Tayada sare, qiimo jaban, adeegyo xirfadeed iyo taageero farsamo, gaarsiin degdeg ah.

TayadaHubinta?Nidaamka xakamaynta tayada adag.Qalabka xirfadlayaasha ah ee falanqaynta waxaa ka mid ah NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Imtixaanka xadka Microbial, iwm.

Tusaalooyinka?Badeecadaha intooda badani waxay bixiyaan muunado bilaash ah oo loogu talagalay qiimeynta tayada, kharashka dhoofinta waa in ay bixiyaan macaamiisha.

Hantidhawrka Warshada?Hantidhawrka warshada soo dhawoow.Fadlan horay u sii ballan.

MOQ?Ma jiro MOQ.Dalabka yar waa la aqbali karaa.

Waqtiga dirida? Haddii ay ku jirto kaydka, dammaanad bixinta saddex maalmood ah.

Gaadiidka?By Express (FedEx, DHL), hawada, badda.

Dukumentiyada?Adeegga iibka kadib: COA, MOA, ROS, MSDS, iwm waa la bixin karaa.

Isku-dhafka gaarka ah?Waxay ku siin kartaa adeegyada isku-dhafka gaarka ah si ay ugu habboonaato baahiyahaaga cilmi-baarista.

Shuruudaha Lacag-bixinta?Qaansheegga Proforma ayaa marka hore la soo diri doonaa ka dib marka la xaqiijiyo dalabka, oo lagu soo lifaaqay macluumaadka bangigayaga.Lacag bixinta T/T (Telex Transfer), PayPal, Western Union, iwm.

72956-09-3 - Macluumaadka Badbaadada:

Xeerarka halista N,Xn
Bayaanada halista 51/53-36/37/38-20/21/22
Bayaanada Badbaadada 61-36-26
RIDADR UN 3077 9/PG 3
WGK Germany 3
RTECS UA8670000
HazardClass IRITANT
PackingGroup III
Xogta Walxaha halista ah 72956-09-3(Xogta Walxaha halista ah)
Sunta LD50 ee afka laga qaato:> 1gm/kg

72956-09-3 -Codsiga:

Carvedilol (CAS: 72956-09-03) waa vasodilating beta-blocker oo faa'iido u leh daaweynta hypertension iyo angina pectoris.Marka laga soo tago hoos u dhigista cadaadiska dhiigga, carvedilol wuxuu hoos u dhigaa wadarta iska caabbinta xididdada dhiigga iyada oo aan la helin tachycardia reflex oo caadi ahaan ku dhaca vasodilators.Waxaa lagu soo waramayaa in si wanaagsan loogu dul-qaatay saameynada kelyaha.

Carvedilol waxaa markii ugu horeysay laga bilaabay Beljamka 1985. Alaabtani waxay xannibi kartaa alfa iyo beta reseptors, ma jiraan wax dhaqdhaqaaq gudaha ah, oo leh heerar sare oo moodada ah oo leh kalsiyum ka soo horjeeda.Waxay leedahay saameyn xoog leh oo xannibaya soo-dhoweynta beta, taas oo ballaarin karta xididdada dhiigga, yareyn karta caabbinta durugsan iyo hoos u dhigidda cadaadiska dhiigga, saameyn yarna ku leh wax soo saarka wadnaha iyo garaaca wadnaha.Kiliinikada waxaa loo isticmaali karaa hypertension aasaasiga ah iyo angina pectoris.

72956-09-3 - USP 35 Heerka:

Qeexitaan
Carvedilol wuxuu ka kooban yahay NLT 98.0% iyo NMT 102.0% ee C24H26N2O4, oo lagu xisaabiyo sal qallalan.
AQOONSIGA
• A. Nuugista Infrared <197K>
B. Wakhtiga haynta ee ugu sarraysa ee xal muunadu waxay u dhigantaa kan xalalka caadiga ah, sida lagu helay Assay.
ASSAY
Habka
Bakhaar: 2.72 g/L oo ah fosfatta potassium monobasic.Ku hagaaji aashitada fosfooraska ku milmi pH ah 2.0.
Marxaladda mobilada: Acetonitrile iyo Buffer (31:69)

Xalka ku habboonaanta nidaamka: 0.05 mg/mL mid kasta oo USP Carvedilol RS iyo USP Carvedilol La Xiriira Isku-dhafka A RS ee marxaladda mobilada
Xalka caadiga ah: 0.04 mg/mL ee USP Carvedilol RS ee marxaladda mobilada
Xalka muunada: 0.04 mg/mL ee Carvedilol ee wajiga mobilada
Nidaamka Chromatographic

(Fiiri Chromatography <621>, Habboonaanta Nidaamka.)
Habka: LC
Baaraha: UV 240 nm
Tiirka: 4.6-mm × 15-cm;5-µm xirmo L7
Heerkulka tiirka: 55 ℃
Heerka socodka: 1 ml/min
Wakhtiga orodka: 60 min
Cabbirka duritaanka: 10 µL
Ku habboonaanta nidaamka

Tusaalaha: Xalka ku habboonaanta nidaamka
Shuruudaha ku habboonaanta

Xallinta: NLT 4.0 inta u dhaxaysa carvedilol iyo carvedilol-ka laxiriira A
Qodobka dabada: NMT 1.5 ee carvedilol ugu sarreeya
Qiyaasta heerka qaraabada: NMT 2%
Falanqaynta

Tusaalooyinka: Xalka caadiga ah iyo xalalka muunada
Xisaabi boqolkiiba carvedilol (C24H26N2O4) ee qaybta muunada la qaaday:
Natiijadu = (rU/rS) × (CS/CU) × 100
rU= jawaabta ugu sarreysa ee carvedilol ee xalka Tusaalaha
rS= jawaabta ugu sarreysa ee carvedilol ee xalka Standard
CS= fiirsashada carvedilol ee xalka caadiga ah (mg/mL)
CU= fiirsashada Carvedilol ee xalka Tusaalaha (mg/mL)
Shuruudaha aqbalaadda: 98.0% -102.0% ee salka qallalan
XANUUNKA
• Hadhaaga dabka <281>: NMT 0.1% laga bilaabo 1 g
• Biraha culus, Habka II <231>: NMT 10 ppm
• Wasakhyada Dabiiciga ah, Habka 1: [Xusuusin-Oo ku saleysan waxyaalaha wasakhda ah ee jira, samee midkoodna wasakhaynta dabiiciga ah, habka 1 ama wasakhaynta dabiiciga ah, habka 2. Waxyeelada dabiiciga ah, Habka 2 ayaa lagula talinayaa marka carvedilol laxiriira xayndaabyada F waa wasakh iman kara.]

Marxaladda kaydka iyo moobilka: U diyaari sida lagu faray Assay.
Xalka ku habboonaanta nidaamka: 0.05 mg/mL mid kasta oo ka mid ah USP Carvedilol RS iyo USP Carvedilol La Xiriira Isku-dhafka C RS ee wajiga wareega
Xalka caadiga ah: 1 µg/mL mid kasta oo ka mid ah USP Carvedilol RS, USP Carvedilol La Xiriira Isku-dhafka A RS, USP Carvedilol La Xiriira Isku-dhafka B RS, USP Carvedilol La Xiriira Isku-dhafka D RS, iyo USP Carvedilol La Xiriira Isku-dhafka E RS, iyo 0.2 µg/mL ee USP Carvedil Isku dhafka C RS ee laxidhiidha ee wajiga mobaylka
Xalka muunada: 1 mg/mL ee Carvedilol ee wajiga mobaylka
Nidaamka Chromatographic
(Fiiri Chromatography <621>, Habboonaanta Nidaamka.)
Habka: LC

Baaraha: Mawjadaha laba-geesoodka ah, UV 220 iyo 240 nm.Isticmaal 220 nm si aad u qiyaasto carvedilol E, oo u isticmaal 240 nm carvedilol iyo dhammaan xeryahooda kale ee la xiriira.
Tiirka: 4.6-mm × 15-cm;5-µm xirmo L7
Heerkulka tiirka: 55 ℃
Heerka socodka: 1 ml/min
Cabbirka duritaanka: 20 µL
Ku habboonaanta nidaamka

Tusaalaha: Xalka ku habboonaanta nidaamka
Shuruudaha ku habboonaanta

Xallinta: NLT 17 inta u dhaxaysa carvedilol iyo carvedilol ee laxiriira xarunta C
Falanqaynta
Tusaalooyinka: Xalka caadiga ah iyo xalalka muunada
Xisaabi boqolleyda carvedilol-ka laxiriira A, kaarvedilol B, C, carvedilol D, carvedilol E, iyo wax kasta oo wasakh kale oo shakhsi ah oo ku jira qaybta Carvedilol ee la qaatay:
Natiijadu = (rU/rS) × (CS/CU) × 100
rU = jawaabta ugu sarreysa ee isku dhafka laxiriira ama wax kasta oo wasakh kale ah oo ka yimaada xalka Tusaalaha
rS = jawaabta ugu sarreysa ee isku dhafka laxiriira ee ka yimid xalalka Standard.Si loo xisaabiyo boqolleyda wasakh kale ee shakhsi ahaaneed isticmaal jawaabta ugu sarreysa ee carvedilol.
CS = fiirsashada xarunta u dhiganta ee la xiriirta xalalka caadiga ah (mg/mL).Si loo xisaabiyo boqolkiiba wixii wasakh kale ah ee CS, isticmaal xoojinta USP Carvedilol RS.
CU = fiirsashada Carvedilol ee xalka Tusaalaha (mg/mL)
Shuruudaha aqbalaadda: eeg Shaxda 1.

Shaxda 1
Magaca Waqtiga Haynta Qaraabo Shuruudaha Ogolaanshaha, NMT (%)
Isku dhafka Carvedilol Ea 0.35 0.1
Isku-dhafka Carvedilol Ab 0.52 0.1
Carvedilol bisalkylpyrocatechol derivative (haddii uu jiro)c 0.70 0.15
Carvedilol 1.0 -
Isku-dhafka Carvedilol ee Cd 3.6 0.02
Iskudhis la xidhiidha Carvedilol De 5.0 0.1
Carvedilol laxiriira iskudarka Bf 8.5 0.1
Wax kasta oo kale oo nijaas ah oo shakhsi ah - 0.10
Wadarta wasakhda - 0.5g
a 2-(2-Methoxyphenoxy) ethyl amin.
b 1- (4- (2-Hydroxy-3--2- (2-methoxyphenoxy) ethylamino)propoxy) -9H-carbazol-9-yl)-3-(2-- -ol.
c 3,3¢-{2,2¢-[1,2-Phenylenebis(oxy)]bis(ethane-2,1-diyl)}bis(azanediyl)bis(1-(9H-carbazol-4-yloxy) propan-2-ol).
d 1- (9H-Carbazol-4-yloxy) -3- (benzyl (2- (2-methoxyphenoxy) ethyl)amino) propan-2-ol.
e 4-(Oxiran-2-ylmethoxy) -9H-carbazole.
f 3,3¢-(2- (2-Methoxyphenoxy)etylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol).
g Iska ilaali wasakh kasta oo ka yar 0.01%.
• Wasakhyada Dabiiciga ah, Habka 2

Xalka A: Acetonitrile iyo trifluoroacetic acid (100:0.1)
Xalka B: Trifluoroacetic acid iyo biyo (0.1:100)
Dareeraha: Acetonitrile, trifluoroacetic acid, iyo biyo (22:0.1:78)
Marxaladda mobilada: eeg Shaxda 2
Shaxda 2
Waqtiga
(min)		 Xalka A
(%)		 Xalka B
(%)
0 22 78
20 22 78
33 38 62
45 38 62
55 55 45
65 55 45
68 22 78
80 22 78
Xalka ku habboonaanta nidaamka: 1.0 mg/mL ee nidaamka USP Carvedilol Ku habboonaanta Isku-dhafka RS ee Diluent
Xalka muunada: 1 mg/mL ee Carvedilol ee dareeraha ah
Nidaamka Chromatographic
(Fiiri Chromatography <621>, Habboonaanta Nidaamka.)
Habka: LC
Baaraha: UV 240 nm
Tiirka: 4.6-mm x 15-cm;5-µm xirmada L68
Heerkulka tiirka: 30℃
Heerka socodka: 1.4 ml/min
Cabbirka duritaanka: 20 µL
Ku habboonaanta nidaamka
Tusaalaha: Xalka ku habboonaanta nidaamka
Shuruudaha ku habboonaanta
Xallinta: NLT 1.8 inta u dhaxaysa carvedilol iyo carvedilol laxiriirta iskudarka F
Falanqaynta
Tusaalaha: Tusaale xal
Xisaabi boqolkiiba wasakh kasta ee qaybta Carvedilol ee la qaatay:
Natiijadu = (rU/rT) × 100
rU = jawaabta ugu sarreysa ee wasakh kasta oo ku jirta xalka Tusaalaha
rT = wadarta dhammaan jawaabaha ugu sarreeya ee xalka Tusaalaha
Shuruudaha aqbalaadda: eeg Shaxda 3.
Shaxda 3

Magaca Qaraabo
Haysashada
Waqtiga		 Ogolaanshaha
Shuruudaha,
NMT (%)
Isku-dhafka Carvedilol Aa 0.7 0.1
Carvedilol 1.0 -
Iskudhis la xidhiidha Carvedilol Fb 1.2 0.1c
N-Isopropylcarvedilold 1.6 0.1
Isku-dhafka Carvedilol ee Ce 1.8 0.02
Carvedilol laxiriira iskudarka Bf 2.1 0.1
Biscarbazoleg 3 0.1
Wax kasta oo kale oo nijaas ah oo shakhsi ah - 0.1
Wadarta wasakhda - 0.5
a 1- (4- (2-Hydroxy-3--2- (2-methoxyphenoxy) ethylamino)propoxy) -9Hcarbazol-9-yl)-3-(2- (2-methoxyphenoxy) ethylamino) propan-2-ol .
b 1- (2- (2-Methoxyphenoxy) ethylamino) -3- (6,7,8,9-tetrahydro-5H-carbazol-4-yloxy) propan-2-ol.
c Nijaastan waxaa lagu qiyaasaa iyadoo la isticmaalayo nidaamka hoos yimaada wasakh-dabiiciga dabiiciga ah, habka 3: Compound la xidhiidha Carvedilol F.
d 1-(H-Carbazol-4-yloxy)-3-[[2- (2-methoxyphenoxy) ethyl] N-isopropylamino]-2-propanol.
e 1- (9H-Carbazol-4-yloxy) -3- (benzyl (2- (2-methoxyphenoxy) ethyl)amino) propan-2-ol.
f 3,3'-(2- (2-Methoxyphenoxy)etylazanediyl)bis (1- (9H-carbazol-4-yloxy) propan-2-ol).
g 1,3-Bis-(9H-carbazol-4-yloxy)-2-propanol.
• Wasakhyada Dabiiciga ah, Habka 3: Isku-dhafka Carvedilol ee F (haddii uu jiro)

Xalka A: Trifluoroacetic acid iyo biyo (0.5:100)
Xalka B: Methanol iyo trifluoroacetic acid (100: 0.5)
Qalafiyaha: Biyaha iyo acetonitrile (1:1)
Marxaladda mobilada: Xalka A iyo Xalka B (65:35)
Xalka ku habboonaanta nidaamka: 1.5 mg/mL ee nidaamka USP Carvedilol Ku habboonaanta Isku-dhafka RS ee Diluent
Xalka muunada: 1.5 mg/mL ee Carvedilol ee Diluent loo diyaariyey sida soo socota.Isticmaal qiyaastii 1.9 ml of Diluent halkii mg ee Carvedilol, iyo sonicate si kooban si loo fududeeyo milanka.
Nidaamka Chromatographic

(Fiiri Chromatography <621>, Habboonaanta Nidaamka.)
Habka: LC
Baaraha: UV 226 nm
Tiirka: 4.6-mm × 30-mm;3-µm xirmo L7
Heerkulka tiirka: 40 ℃
Heerka socodka: 2 ml/min
Cabbirka duritaanka: 10 µL
Ku habboonaanta nidaamka
Tusaalaha: Xalka ku habboonaanta nidaamka
Shuruudaha ku habboonaanta
Xallinta: NLT 2.0 inta u dhaxaysa carvedilol iyo carvedilol isku darka F
Falanqaynta
Tusaalaha: Tusaale xal
Xisaabi boqolleyda carvedilol ee laxiriira kaamka F ee qaybta muunada la qaaday:
Natiijadu = (rU/rT) × (1/F) × 100
rU = jawaabta ugu sarreysa ee carvedilol ee laxiriirta xayndaabka F ee xalka Tusaalaha
rT = wadarta jawaabaha ugu sarreeya ee carvedilol iyo carvedilol ee laxiriira xayndaabka F ee xalka Tusaalaha
F = qodobka jawaabta qaraabo, 1.1
Shuruudaha aqbalaadda: NMT 0.1%
IMTIXAANO GAAR AH
• Luminta qallajinta <731>: Ku qalaji muunad 105 ℃ 3 saacadood: waxay luminaysaa NMT 0.5% miisaankeeda.
SHURUUD DHEERAAD AH
Baakadaha iyo Kaydinta: Ku kaydi weelal cidhiidhi ah, oo ku kaydi heerkulka qolka kontaroolan.
• Calaamadaynta: Haddii tijaabada HPLC ee wasakhda dabiiciga ah la isticmaalo oo aan ahayn Habka 1, markaa calaamadaynta ayaa sheegaysa tijaabada uu maqaalku raacayo.
• Heerarka Tixraaca USP <11>

USP Carvedilol RS
Isku dhafka USP Carvedilol A RS
1- (4- (2-Hydroxy-3---2-------- ol.
C36H43N3O7 629.74
Isku dhafka USP Carvedilol B RS
3,3'-(2- (2-Methoxyphenoxy)etylazanediyl)bis (1- (9H-carbazol-4-yloxy) propan-2-ol).
C39H39N3O6 645.74
Isku dhafka USP Carvedilol La Xiriira C RS
1- (9H-Carbazol-4-yloxy) -3- (benzyl (2- (2-methoxyphenoxy) ethyl)amino) propan-2-ol.
C31H32N2O4 496.60
Isku dhafka USP Carvedilol la xiriira D RS
4-(Oxiran-2-ylmethoxy) -9H-carbazole.
C15H13NO2 239.27
Isku dhafka USP Carvedilol E RS
2- (2-Methoxyphenoxy) ethyl amin.
C9H13NO2 167.21
Isku dhafka Habboon ee Nidaamka USP Carvedilol RS
Isku darka qiyaastii 0.1% carvedilol la xidhiidha isku-dhafka F (1- (2- (2-Methoxyphenoxy) ethylamino) -3- (2,3,4,9-tetrahydro-1H-carbazol-5-yloxy) propan-2-ol) ee matrixka walaxda daroogada carvedilol.
Halkan ku qor fariintaada oo noo soo dir