Daclatasvir Dihydrochloride Dhexdhexaad CAS 1007882-23-6 daahirnimo>98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. waa saaraha ugu horreeya ee Daclatasvir Dihydrochloride Intermediate (CAS: 1007882-23-6) oo leh tayo sare.Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, tiro yar iyo tiro badan oo la heli karo.Iibso Daclatasvir Dihydrochloride Dhexdhexaadiyeyaasha,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | Di-tert-Butyl (2S,2'S)-2,2'-(4,4'-Biphenyldiylbis(1H-imidazole-5,2-diyl))di(1-Pyrrolidinecarboxylate) |
| La mid ah | Daclatasvir Dhexdhexaadiyaha Ⅱ;Dacaltasvir Dhexdhexaad 02;Daclatasvir T-Butyl Ester;Bis (2-Methyl-2-Propanyl) (2S,2'S) -2,2'- [4,4'-Biphenyldiylbis(1H-Imidazole-4,2-diyl)]di (1-Pyrrolidinecarboxylate);Di-tert-butyl 2,2′-([1,1′-Biphenyl]-4,4′-diylbis(1H-Imidazole-5,2-diyl))(2S,2'S)-bis(Pyridineidine-1- Carboxylate;(2S,2'S)-2,2'-([1,1'-Biphenyl]-4,4'-diyldi-1H-Imidazole-5,2-diyl)bis-1-Pyrrolidinecarboxylic Acid 1,1'-Bis (1,1-Dimethylethyl) Ester;Daclatasvir wasakh 4 |
| Heerka Saamiyada | Suuqa dhexdiisa, Wax-soo-saarka Ganacsiga |
| Lambarka CAS | 1007882-23-6 |
| Qaanuunka molecular | C40H51ClN8O6 |
| Miisaanka Molecular | 775.35 g/mol |
| Barta Karsan | 890.2± 65.0℃ at 760 mmHg |
| Cufnaanta | 1.220± 0.06 g/cm3 |
| COA & MSDS | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Qaybta | Dhexdhexaadiyaha Daclatasvir Dihydrochloride (CAS: 1009119-65-6) |
| Summada | Kiimikada Ruifu |
| Walxaha | Tilmaamaha | Natiijooyinka |
| Muuqashada | Jaalle fudud ilaa budada jaalaha ah | Budada Jaallaha fudud |
| Khasaare xagga qalajinta | <1.00% | 0.65% |
| Xumaanta Keliga ah ee ugu badan | <1.00% | 0.45% |
| Wadarta wasakhda | <2.00% | 1.24% |
| Daahirnimada / Habka Falanqaynta | >98.0% (HPLC) | 98.76% |
| Infrared Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| 1H NMR Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| Gabagabo | Alaabtu waa la tijaabiyay oo waafaqday tilmaamihii la bixiyay | |
| Codsiga | Dhexdhexaadiyaha Daclatasvir Dihydrochloride (CAS: 1009119-65-6) | |
Xidhmada:Dhalada fluorinated, bacda bireed aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
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Sidee loo Iibsadaa?Fadlan la xidhiidhDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Khibrad 15 Sano ah?Waxaan leenahay in ka badan 15 sano oo waayo-aragnimo ah oo ku saabsan soo saarista iyo dhoofinta ee tiro balaadhan oo ah dhexdhexaad ah daawooyinka tayada sare leh ama kiimikooyinka ganaax.
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Di-tert-Butyl (2S,2'S)-2,2'-(4,4'-Biphenyldiylbis(1H-imidazole-5,2-diyl))di(1-Pyrrolidinecarboxylate) (CAS: 1007882-23-6) waa dhexe ee Daclatasvir Dihydrochloride (CAS: 1009119-65-6).
Daclatasvir (Daklinza) ayaa heshay heerka "dib u eegista mudnaanta leh", oo ay weheliso Sorafenib ee daaweynta genotype III bukaannada qaangaarka ah ee qaba cagaarshow C dabadheeraad ah. caabuqa iyada oo aan la wadaagin interferon ama ribavirin.Interferon iyo Ribavirin waa laba daawo oo ay FDA u ansixisay daaweynta caabuqa cagaarshow C.Cagaarshowga C waa cudur fayras ah oo keeni kara barar beerka, taasoo keenta hoos u dhaca shaqada beerka ama beerka oo shaqayn waayo.Bukaanjiifka qaba cagaarshowga C intooda badan ma laha calaamado ilaa uu ka soo shaac baxo dhaawaca beerka, kaas oo qaadan kara dhowr sano.Caalam ahaan, genotype III cagaarshowga C waa genotype-ka labaad ee ugu caansan cagaarshowga C ka dib genotype 1 cagaarshow C waxaana loo arkaa mid ka mid ah cudurrada genotype ee ugu caansan.Daklinza waa pan-genotype NS5A dib-u-celinta isku-dhafan ee ka-hortagga, oo leh waxtarka xakamaynta taranka RNA iyo isu-ururinta fayraska, saameyn laba geesood ah.Daraasadaha in vitro, Daklinza ayaa lagu muujiyay in ay leedahay saameyn lid ku ah fayraska ka hortagga genotype 1 ~ 6 fayraska cagaarshow C.Daklinza waxaa weheliya digniin ah in isku-darka amiodarone, Daklinza iyo Sofosbuvir ay keeni karto hoos u dhac weyn oo garaaca wadnaha.Daklinza waa kiniin afka laga qaato oo leh qiyaasta lagu taliyey ee 60 mg 1 jeer/d, iyadoo lala kaashanayo Sofosbuvir wadar ahaan 12 toddobaad.
Shirkadda cilmi-baarista iyo horumarinta: Bristol-Myers Squibb.
Suugaanta Patent: WO 2008021927A2 (Agoosto 9, 2007).
Waqtiga suuqgeynta: Luulyo 24, 2015 oo ku taxan gudaha Mareykanka, magaca ganacsiga Daklinza.
Tilmaamaha: Waxaa loo isticmaalaa marka lagu daro Sofosbuvir daawaynta genotype 3 cagaarshowga C (HCV) ee raaga.
Habka ficilka: HCV borotiinka aan qaabdhismeedka lahayn ee 5A (NS5A) horjoogayaasha.Dareen-celinta xun: madax-xanuun iyo daal.
Samaynta iyo qeexida: Kiniinnada, 30 iyo 60mg.
