Risperidone CAS 106266-06-2 Assay 98.0 ~ 102.0%
Shanghai Ruifu Chemical Co., Ltd. waa soo saaraha ugu horreeya ee Risperidone (CAS: 106266-06-2) oo leh tayo sare.Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibso Risperidone,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | Risperidone |
| La mid ah | 3-[2-[4-(6-Fluoro-1,2-Benzisoxazol-3-yl)-1-Piperidinyl] ethyl]-6,7,8,9-Tetrahydro-2-Methyl-4H-Pyrido[1 ,2-a]pyrimidin-4-kow;Risperdal;Risperidal;Risperdal Consta;Rispolept;Risperin;Rispolin;Sequinan;Risperdal M-Tab |
| Heerka Saamiyada | Suuqa dhexdiisa, Wax-soo-saarka Ganacsiga |
| Lambarka CAS | 106266-06-2 |
| Qaanuunka molecular | C23H27FN4O2 |
| Miisaanka Molecular | 410.49 g/mol |
| Meesha dhalaalaysa | 170.0 ilaa 174.0 ℃ |
| Cufnaanta | 1.38± 0.10 g/cm3 |
| Heerka khatarta | 6.1;Sun |
| COA & MSDS | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Summada | Kiimikada Ruifu |
| Walxaha | Tilmaamaha | Natiijooyinka |
| Muuqashada | Caddaan ilaa budo cad-cad | U hogaansama |
| Aqoonsiga A | Nuugista Infrared | U hogaansama |
| Aqoonsiga B | Waqtiga Haynta: Waxay la mid tahay walxaha tixraaca | U hogaansama |
| Khasaare xagga qalajinta | <0.50% | 0.12% |
| Hadhaaga dabka | <0.10% | 0.07% |
| Biraha culus | <0.001% | <0.001% |
| Isku dhafka la xiriira | ||
| E-Oxime | <0.20% | <0.20% |
| Z-Oxime | <0.20% | <0.20% |
| 9-Hydroxyrisperidone | <0.20% | <0.20% |
| 5-Fluororisperidone | <0.20% | <0.20% |
| 6-Methylrisperidone | <0.20% | <0.20% |
| Wax kasta oo wasakh ah oo aan la garanayn | <0.10% | <0.10% |
| Wadarta wasakhda | <0.30% | <0.30% |
| Qiimayn | 98.0 ~ 102.0% (waxaa lagu xisaabiyaa ku salaysan qalalan) | 100.52% |
| Gabagabo | Alaabta waa la tijaabiyay oo waafaqday heerka USP 35 | |
Xidhmada:Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Weelka si adag u xidh oo ku kaydi qabow, qalalan (2 ~ 8 ℃) iyo bakhaar hawo wanaagsan leh oo ka fog walxaha aan ku habboonayn.Ka ilaali iftiinka iyo qoyaanka.
Rarida:Ku gaarsii adduunka oo dhan hawo, by FedEx/DHL Express.Bixi keenid degdeg ah oo la isku halayn karo.
Risperidone
C23H27FN4O2 410.48
4H-Pyrido[1,2-a]pyrimidin-4-kow, 3-[2-[4- (6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl] ethyl]-6,7 ,8,9-tetrahydro-2-methyl-.
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl) piperidino] ethyl] -6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-kow [106266-06-2].
» Risperidone waxa uu ka kooban yahay wax aan ka yarayn 98.0 boqolkiiba oo aan ka badnayn 102.0 boqolkiiba C23H27FN4O2, oo lagu xisaabiyay hab qalalan.
Baakadaha iyo kaydinta- Ku kaydi weelasha si fiican u xidhan.Ku kaydi heerkulka qolka.
Heerarka Tixraaca USP <11>-
USP Risperidone RS
3-[2-[4- (6-fluoro-1,2-benzisoxazol-3-yl) piperidino] ethyl] -6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-hal 410.48 CAS-106266-06-2
Isku darka Habboon ee Nidaamka USP Risperidone RS
Waxa ku jira risperidone iyo ilaa 0.2% mid kasta oo ka mid ah kuwan soo socda:
Z-Oxime-3-[2-[4-[(Z)-(2,4-difluorophenyl) (hydroxyimino) methyl] piperidin-1-yl] ethyl] -2-methyl-6,7,8,9- tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-kow.
9-Hydroxyrisperidone- (6RS) -3-[2-[4- (6-fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl] -2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-hal.
6-Methylrisperidone- (6RS) -3-[2-[4- (6-fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl] -2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-hal.
[Fiiro gaar ah: Isku-dhafkan wuxuu ka kooban yahay risperidone, Z-oxime, 9-hydroxyrisperidone, iyo 6-methylrisperidone.]
Aqoonsiga -
J: Nuugista Infrared <197K>.
B: Waqtiga haynta ee ugu sarreysa chromatogram-ka diyaarinta Assay waxay u dhigantaa tan ku jirta chromatogram-ka diyaarinta Heerka, sida laga helay Assay.
Luminta qalajinta <731>- Ku qallaji faakuum 80 ilaa 4 saacadood: waxay luminaysaa wax aan ka badnayn 0.5% miisaankeeda.
Hadhaaga dabka <281>: aan ka badnayn 0.1%, muunado 2.0-g oo tijaabo ah ayaa la isticmaalayaa.
Biraha culus, Habka II <231>: 0.001%.
Iskudhisyada la xidhiidha-
Xalka Buffer, Xalka A, Xalka B, Wajiga Mobilada, Diluent, Xalka ku habboonaanta Nidaamka, iyo Nidaamka Chromatographic-U diyaari sida lagu faray Assay.
Xalka caadiga ah-Isticmaal diyaarinta heerka, loo diyaariyey sida lagu faray Imtixaanka.
Tijaabi xalka-Isticmaal diyaarinta Assay.
Habka-Ku dur mugga siman (qiyaastii 10 µL) ee xalka caadiga ah iyo xalka tijaabada chromatograph-ka, oo duub chromatogramka.Aqoonso waxyaalaha wasakhda ah adoo isticmaalaya wakhtiyada haynta qaraabada ah ee lagu sheegay shaxda 1, oo cabbir jawaabaha ugu sarreeya.Xisaabi boqolleyda xarun kasta oo la xidhiidha risperidone ee qaybta Risperidone ee ay qaadatay qaacidada:
100 (CS / CU) (rU / rS) (1/F)
kuwaas oo CS iyo CU ay yihiin uruurinta, mg per mL, ee risperidone ee xalalka Heerka iyo xalka Imtixaanka siday u kala horreeyaan;rU waa meesha ugu sarreysa ee wasakh kasta oo laga helo xalka Tijaabada;rS waa meesha ugu sarreysa ee risperidone ee laga helay xalalka caadiga ah;iyo F waa qodobka jawaabta u dhiganta ee nijaas kasta oo la xiriirta risperidone.Marka lagu daro in aan ka badnayn xadka shaxda 1, in aan ka badnayn 0.10% wasakh kasta oo aan la garanayn (isticmaalka qiimaha F ee 1.0) ayaa la helay oo aan ka badnayn 0.30% wadarta wasakhda.Iska ilaali meelaha ugu sarreeya ee wasakhda ah ee ka yar 0.05%.
Shaxda 1
Wakhtiga Haynta Qaraabada ee Xidhiidhka Laxidhiidha
E-oxime1 0.60 1.0 NMT 0.20
Z-oxime2 0.67 0.63 NMT 0.20
9-hydroxyrisperidone3 0.76 0.92 NMT 0.20
5-fluororisperidone4 0.94 1.0 NMT 0.20
Risperidone 1.0 1.0 -
6-methylrisperidone5 1.2 0.95 NMT 0.20
1 3-[2-[4-[(E)-(2,4-Difluorophenyl) (hydroxyimino) methyl] piperidin-1-yl] ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-kow
2 3-[2-[4-[(Z)-(2,4-Difluorophenyl) (hydroxyimino) methyl] piperidin-1-yl] ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-kow
3 (9RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl]-9-hydroxy-2-methyl-6,7,8 ,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-hal
4 3-[2-[4- (5-Fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido [1,2-a]pyrimidin-4-kow
5 (6RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl) piperidin-1-yl] ethyl]-2,6-dimethyl-6,7,8,9 -tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-hal
Imtixaan-
Xalka Buffer-Ku mil 15.4 g oo ammonium acetate ah 1 L oo biyo ah.Ku hagaaji 10% acetic acid pH of 6.5, oo qas.
Xalka A- Isku qas 100 mL oo ah xal Buffer leh 150 ml oo methanol ah oo ku jira 1000-mL weel mug leh, oo ku mil biyo ilaa mug.
Xalka B- Isku qas 100 mL oo ah xal buffer iyo 850 ml oo methanol ah oo ku jira 1000-mL oo weel mug leh, oo ku mil biyo ilaa mug.
Marxaladda mobilada-Isticmaal isku dhafka kala duwan ee Xalka A iyo Xalka B sida lagu faray nidaamka Chromatographic.Samee hagaajin haddii loo baahdo (eeg Habboonaanta Nidaamka ee hoos timaada Chromatography 621).
Dareemka-Ku qas 100 mL oo ah xalinta 900 ml oo biyo ah iyo 1000 ml oo methanol ah.
Xalka ku habboonaanta nidaamka-U diyaari 1 mg halkii ml ee USP Risperidone Nidaamka Ku habboonaanta Isku-dhafka RS ee Diluent.
Diyaargarowga caadiga ah-Ku milmaan tirada saxda ah ee USP Risperidone RS ee Diluent, oo u milo tiro ahaan, iyo si tartiib tartiib ah haddii loo baahdo, iyadoo la isticmaalayo Diluent si loo helo xal isagoo leh uruur la og yahay oo ku saabsan 1.0 mg halkii ml.
Diyaarinta Assay-Ku milmi tiro sax ah oo la miisaamay oo Risperidone ah oo ku jirta Diluent, oo u milo tiro ahaan, iyo tallaabo tallaabo haddii loo baahdo, iyadoo la isticmaalayo Diluent si loo helo xal isagoo ku urursan qiyaastii 1.0 mg halkii ml.
Nadaamka Chromatographic (fiiri Chromatography <621>)--Kromaatograph-ka dareeraha ah waxa uu ku qalabaysan yahay 275-nm baaraha iyo tiir 4.6-mm × 10-cm ah oo ka kooban 3-µm xirmo L1.Heerka socodka waa qiyaastii 1.5 mL daqiiqadii.Heerkulka tiirka waxaa lagu hayaa 35. chromatograph-ka waxaa loo habeeyey sida soo socota.
Waqtiga (daqiiqado) Xalka A (%) Xalka B (%) Elution
0–1 70 30 isocratic
1–20 70®5 30®95 jaanis toosan
20-25 5 95 isocratic
25–27 5®70 95®30 jaanis toosan
27-35 70 30 dib-u-equilbration Duri xalka ku habboonaanta nidaamka.Qor jawaabaha ugu sarreeya sida lagu faray Habraaca, oo cadee meelaha ugu sarreeya sababtoo ah Z-oxime, 9-hydroxyrisperidone, 6-methylrisperidone, iyo risperidone adoo isticmaalaya waqtiyada haynta qaraabo (RRT) ee shaxda 1;xallinta, R, inta u dhaxaysa Z-oxime iyo 9-hydroxyrisperidone waa mid aan ka yarayn 2.8;Qodobka dabada ee risperidone kama badna 1.5;iyo jaangooyada heerka qaraabo ee loogu talagalay cirbadaha soo noqnoqda kama badna 2.0% ee ugu sarreysa risperidone.
Habka- Si gooni ah u duri mugga siman (qiyaastii 10 µL) ee diyaarinta Heerka iyo diyaarinta Assay chromatograph, oo cabbir jawaabaha ugu sarreeya risperidone.Xisaabi tirada, boqolkiiba C23H27FN4O2, ee qaybta Risperidone ee ay qaadatay qaacidada:
100 (CS / CU) (rU / rS)
taas oo CS iyo CU ay yihiin uruurinta, mg per mL, ee risperidone ee diyaarinta Standard iyo diyaarinta Assay, siday u kala horreeyaan;iyo rU iyo rS waa jawaabaha ugu sarreeya ee laga helay diyaarinta Assay iyo heerka diyaarinta, siday u kala horreeyaan.
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Aqoonsiga Qaramada Midoobay 3249
WGK Germany 3
RTECS UV1164800
HS code 2934999099
Heerka khatarta 6.1 (a)
Kooxda Baakadaha II
Risperidone (CAS: 106266-06-2) waxay saameyn liddi ku ah ku leedahay 5HT2 reseptors iyo D2 reseptors.Risperidone waxaa loo isticmaalaa schizophrenia ba'an iyo dabadheeraad ah.Daawooyinka dhimirka.Risperidone waxaa loo isticmaalaa daawaynta schizophrenia ba'an iyo dabadheeraad ah iyo xaalado kale oo nafsiyeed oo kala duwan oo muuqda calaamado muuqda (sida dhalanteedka, dhalanteedka, khalkhalka fikirka, cadaawad, shaki) iyo calaamado taban oo weyn (sida jawaab-la'aan, dareen la'aan iyo dareen la'aan bulsheed. erayada).Sidoo kale waxay yaraynaysaa calaamadaha saamaynta leh ee la xidhiidha schizophrenia (sida: niyad-jabka, eedda, welwelka).Bukaanada ay Risperidone waxtar u leedahay daaweynta degdega ah, marxaladda dayactirka ee daaweynta, Risperidone waxay sii wadi kartaa inay ciyaarto waxtarkeeda caafimaad.Risperidone, sidaas darteed, waxay leedahay ficil daweyn oo ku saabsan labadaba calaamadaha togan iyo kuwa taban ee schizophrenia waxayna soo saartaa waxyeelo aad u yar gaar ahaan calaamadaha ka baxsan pyramidal marka loo eego sida caadiga ah loo isticmaalo D2 antagonist antipsychotics.Waxa kale oo ay leedahay awood lagu maareeyo ka-saarista khamriga iyo qabatinka kookeynta.
