4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid CAS 123654-26-2 Prucalopride Succinate daahirnimo Dhexdhexaad ah ≥98.0% (HPLC)
Shanghai Ruifu Chemical waa soo saaraha ugu horreeya ee 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid (CAS: 123654-26-2) oo leh tayo sare leh.Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibka Prucalopride Dhexdhexaadiyaha Succinate,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid |
| La mid ah | 4-Amino-5-Chlorocoumaran-7-Carboxylic Acid;4-Amino-5-Chloro-2,3-Dihydrobenzo[b]furan-7-Carboxylic Acid;4-Amino-5-Chloro-2,3-Dihydro-1-Benzofuran-7-Carboxylic Acid;4-Amino-5-Chloro-2,3-Dihydro-7-Benzofurancarboxylic Acid;Prucalopride wasakh A;Prucalopride Succinate wasakh-2 |
| Heerka Saamiyada | Suuqa dhexdiisa, Wax-soo-saarka Ganacsiga |
| Lambarka CAS | 123654-26-2 |
| Qaanuunka molecular | C9H8ClNO3 |
| Miisaanka Molecular | 213.62 g/mol |
| Meesha dhalaalaysa | 242 ℃ (dac.) |
| Barta Karsan | 406.5 ± 45.0 ℃ |
| Cufnaanta | 1.566 |
| COA & MSDS | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Qaybta | Dhexdhexaadiyaha Prucalopride Succinate (CAS: 179474-85-2) |
| Summada | Kiimikada Ruifu |
| Walxaha | Heerarka Kormeerka | Natiijooyinka |
| Muuqashada | Ka-baxsan-cad ilaa Casaan-Casan Adag | Iftiin-Casaan Adag |
| Biyaha waxaa qoray Karl Fischer | ≤1.00% | 0.35% |
| Hadhaaga dabka | <0.20% | 0.08% |
| Biraha culus (Pb) | ≤20pm | <10pm |
| Xumaanta Keliya | ≤1.00% | U hogaansama |
| Wadarta wasakhda | ≤2.00% | U hogaansama |
| Daahirnimada / Habka Falanqaynta | ≥98.0% (HPLC) | 99.6% |
| Infrared Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| 1 H NMR Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| Gabagabo | Alaabta waa la tijaabiyay oo waafaqay tilmaamihii la bixiyay | |
Xidhmada:Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Weelka si adag u xidh oo ku kaydi qabow, qalalan (2 ~ 8 ℃) iyo bakhaar hawo wanaagsan leh oo ka fog walxaha aan ku habboonayn.Ka ilaali iftiinka iyo qoyaanka.
Rarida:Ku gaarsii adduunka oo dhan hawo, by FedEx/DHL Express.Bixi keenid degdeg ah oo la isku halayn karo.
Alaabtani waa 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid, waxa ku jira C12H12ClNO4 waa in aanay ka yarayn 98.0%, oo lagu xisaabiyo ku salaysan anhydrous.
[Properties] Alaabtani waa mid adag oo cad-cad ilaa iftiin-cas ah.
[eeg]
Qaado qadar ku habboon alaabtan (qiyaastii 0.5g) oo biyo ah, ku dar dareere (methanol: N, N-dimethylformamide = 50:50), oo ku milaan si waafaqsan habka go'aaminta biyaha (Lifaaqa Ⅷ M, habka koowaad A).Isticmaal dhibcaha tijaabada Fisher si aad u go'aamiso ilaa uu xalku ka bedelayo huruud khafiif ah oo uu guduudan yahay-brown taasoo muujinaysa barta dhamaadka, oo samee imtixaan kale oo maran.Xisaabi si waafaqsan qaacidada soo socota: waxa ku jira biyuhu waa in aanay ka badnayn 1.00%.
Waxa ku jira qoyaanka (%) = (AB) F/W×100%
Halkee, A waa mugga dareeraha Fisher ee uu isticmaalo alaabta tijaabada ah (ml);
B waa mugga dareeraha tijaabada Fisher ee lagu isticmaalo meel bannaan, ml;
F waa miisaanka xalka tijaabada Fisher oo u dhigma biyaha halkii 1ml, mg;
W waa miisaanka alaabta tijaabada, mg
Walaxda la xidhiidha
Marka loo eego habka hoos yimaada "Qalabka cabbiraadda Mawduuca", haddii ay jiraan meelaha ugu sarreeya ee nijaasta ah ee chromatogram ee xalka tijaabada, aagga ugu sarreeya ee nijaasta keliya waa inuusan ka badnaan 10 jeer (1.0%) ee aagga ugu sarreeya ee kantaroolka. xal, iyo wadarta aagga ugu sarreeya ee dhammaan wasakhooyinka waa in aanay ka badnaan 20 jeer (2.0%) meesha ugu sarreysa ee xalka xakamaynta.
[Go'aaminta nuxurka] Marka loo eego waxqabadka sare ee chromatography dareeraha (Lifaaqa VI D).
Octadecylsilane bonded silica jel waxa loo isticmaalay buuxinta xaaladaha chromatographic iyo imtixaanada ku haboonaanta nidaamka.Xalka fosfooraska (1.36g potassium dihydrogen fosfate, kala diri ultrasonic ee biyaha 1L, fosfooraska acid lagu hagaajiyay PH 3.0) ayaa loo isticmaalay sida wajiga wareega A. Acetonitrile waa wareega wareega B, iyo gradient elution waxaa loo sameeyaa si waafaqsan miiska soo socda:
Waqtiga (min) Wajiga moobilka A wejiga moobilka B
080 20
15 80 20
30 50 50
45 50 50
Dhererka mowjadda ogaanshaha waxay ahayd 254 nm.Heerka socodka wuxuu ahaa 1.0 ml/min.Tirada taarikada aragtidu kama yarayn 2000 marka loo eego heerka ugu sarreeya ee 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid
Ugu sarreeya ee furanoformic acid kama yara 2000.
Habka go'aaminta:
Qaado 10mg oo ah sheyga tijaabada ah, si sax ah u miisaamee, ku rid dhalada 10ml, ku milmi ultrasonic leh wajiga wareega A-mobile wajiga B (70:30) sida dareeraha, milo ilaa miisaanka, si fiican u rux, oo diyaari a xal oo leh fiirsashada 1mg/ml.20 l oo sax ah ayaa lagu duray chromatograph-ka dareeraha ah, chromatogram-kana waa la duubay.Nadiifinta ugu sarraysa kama yarayn 98.0% marka loo eego habka caadiga ah ee aagga ugu sarreeya
Tiirka: Dionex Acclaim C18, 4.6*250mm, 5um
Heerkulka tiirka: 40 ℃
Heerka socodka: 1.0ml/min
Dhererka mowjadda ogaanshaha: 254nm
Cabbirka Tusaalaha: 10μL
Sidee loo Iibsadaa?Fadlan la xidhiidhDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Dukumentiyada?Adeegga iibka kadib: COA, MOA, ROS, MSDS, iwm waa la bixin karaa.
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4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid (CAS: 123654-26-2), waxaa loo isticmaali karaa dhex dhexaad u ah isku-dhafka Prucalopride Succinate (CAS: 179474-85-2), agonist 5-HT4 receptor agonist loo isticmaalo waxtar u leh calool-istaagga raaga.Prucalopride Succinate, oo ah heerka koowaad ee dihydrobenzofurancarboxamide, waa agonist-ka-qaade serotonin (5-HT4).Daawada, oo lagu suuqgeeyay magaca sumadda Resolor®, waxay leedahay dhaqdhaqaaqa enterokinetic waxaana soo saartay shirkadda dawooyinka ee Belgian ee Movetis.Prucalopride waxay beddeshaa qaababka dhaqdhaqaaqa xiidanka iyada oo loo marayo serotonin 5-HT4 kicinta reseptor, kicinta xoogga dhexe ee kicinta ee saxarada.
