CAS 177036-94-1 daahirnimo>99.0% (HPLC) API Nadaafadda Sare ee Warshada
Sahayda Ganacsiga (CAS: 177036-94-1) Dhexdhexaadiyayaasha la xidhiidha:
CAS: 177036-94-1
Methyl 2-Hydroxy-3-Methoxy-3,3-Diphenylpropanoate CAS: 178306-47-3
2-Hydroxy-3-Methoxy-3,3-Diphenylpropanoic Acid CAS: 178306-51-9
(S)-2-Hydroxy-3-Methoxy-3,3-Diphenylpropionic Acid CAS: 178306-52-0
L-Proline Methyl Ester Hydrochlorid CAS: 2133-40-6
4,6-Dimethyl-2-(Methylsulfonyl) pyrimidine CAS: 35144-22-0
Magaca Kiimikada | (S)-2-[(4,6-Dimethylpyrimidin-2-yl) oxy]-3-Methoxy-3,3-Diphenylpropionic Acid |
La mid ah | (+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl) oxy)-3-Methoxy-3,3-Diphenylpropanoic Acid |
Lambarka CAS | 177036-94-1 |
Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
Qaanuunka molecular | C22H22N2O4 |
Miisaanka Molecular | 378.43 |
Wareeg gaar ah [α]D20 | +170.0° ilaa +176.0° (C=0.5, MeOH) |
Meesha dhalaalaysa | 172.0 ~ 178.0 ℃ (dac.) |
Solubility | Aad ugu milmay Methanol;Ku milmay Ethanol, Acetone;Aan ku milmin Biyaha |
Summada | Kiimikada Ruifu |
Shayga | Tilmaamaha |
Muuqashada | Budada cad ama Off-Cad |
Aqoonsiga | HPLC;NMR;LC-MS |
Walxaha laxidhiidha | |
Xumaanta Shaqsiga ah | ≤0.50% |
Wadarta wasakhda | <1.00% |
Khasaare xagga qalajinta | ≤0.50% |
Hadhaaga dabka | ≤0.20% |
Biraha culus | ≤20pm |
Daahirnimada / Habka Falanqaynta | >99.0% (HPLC) |
Heerka Imtixaanka | Heerka Ganacsiga |
Isticmaalka | Dhexdhexaadiyeyaasha Daawooyinka |
Xidhmada: Dhalo, bacda bireed aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka
Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka
(CAS: 177036-94-1) APIwaa antagonist endothelin-A (ETA) oo la xushay oo loo soo bandhigay daaweynta afka ee bukaanka qaba hypertension sambabada (PAH), si loo hagaajiyo awoodda jimicsiga iyo dib u dhigista kiliinikada.PAH waa cudur naadir ah oo ku dhaca halbowlayaasha sambabada yaryar ee lagu garto faafinta xididada iyo dib u habeynta, taasoo keentay koror sii kordhaya ee iska caabbinta sambabada sambabada iyo cadaadiska halbowlaha sambabada, iyo ugu dambeyntii, fashilka saxda ah ee saxda ah iyo dhimashada hore.Calaamadaha ugu horreeya ee PAH waxaa ka mid ah neefta oo si tartiib ah u bilaabata, daal, garaaca wadnaha, barar, iyo miyir beelid.Endothelin-1 (ET-1), vasoconstrictor awood leh iyo mitogen muruqa siman, waa qayb muhiim ah oo ka qaybqaata dardargelinta cudurka, saameyntiisana waxaa lagu dhexdhexaadiyaa iyada oo loo marayo firfircoonida ETA iyo ETB.Bishii Juun 2007, FDA waxay ogolaatay (CAS: 177036-94-1) API daawaynta hal mar ee PAH.