Pramipexole Dihydrochloride Monohydrate CAS 191217-81-9 Assay 98.0 ~ 102.0%

Sharaxaad Gaaban:

Pramipexole Dihydrochloride Monohydrate

La mid ah: Pramipexole DiHCL Monohydrate

CAS: 191217-81-9

Qiimaynta: 98.0 ~ 102.0%

Muuqashada: Caddaan ilaa budo cad-cad

Xiriirka: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Faahfaahinta Alaabta

Alaabooyinka La Xiriira

Tags Product

Sharaxaad:

Kiimikada Ruifu waa soo saaraha ugu horreeya ee Pramipexole Dihydrochloride Monohydrate (CAS: 191217-81-9) oo leh tayo sare.Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibso Pramipexole Dihydrochloride Monohydrate,Please contact: alvin@ruifuchem.com

Guryaha Kiimikada:

Magaca Kiimikada Pramipexole Dihydrochloride Monohydrate
La mid ah Pramipexole DiHCL Monohydrate;Pramipexole 2HCl Monohydrate;(S)-2-Amino-4,5,6,7-Tetrahydro-6-(Propylamino)benzothiazole Dihydrochloride Monohydrate
Heerka Saamiyada Suuqa dhexdiisa, Wax-soo-saarka Ganacsiga
Lambarka CAS 191217-81-9
CAS la xidhiidha 104632-25-9 & 104632-26-0
Qaanuunka molecular C10H17N3S·2HCl·H2O
Miisaanka Molecular 302.26 g/mol
Meesha dhalaalaysa 290 ℃ (diseembar)
Wareeg gaar ah [a]20/D -65.0° ilaa -71.0° (C=1 gudaha MeOH)(calcd.on anh.walax)
Biyuhu milmayn Ku milmay Biyaha
Solubility Ku milma Methanol.Ethanol aad u yar.Aan ku milmin Dichloromethane
COA & MSDS La heli karo
Asal ahaan Shanghai, Shiinaha
Summada Kiimikada Ruifu

Tilmaamaha:

Walxaha Tilmaamaha Natiijooyinka
Muuqashada Caddaan ilaa budo cad-cad Budada Cad
Qiimaynta (waxaa qoray HPLC) 98.0 ~ 102.0% 99.34%
Biyaha waxaa qoray Karl Fischer 4.5-6.5% U hogaansama
Hadhaaga dabka ≤0.10% <0.10%
Biraha culus (Pb) ≤10pm <10pm
Pramipexole Propionamidea ≤0.15% U hogaansama
Isku dhafka Pramipexole ee La Xiriira A ≤0.15% U hogaansama
N-Propylpramipexole ≤0.15% U hogaansama
Pramipexole Dimer ≤0.15% U hogaansama
Wax kasta oo kale oo aan la aqoonsanayn nijaasaha shaqsiyeed ≤0.10% U hogaansama
Nadiifinta Enantiomeric ≤1.00% U hogaansama
Palladium ≤5pm <5pm
Infrared Spectrum Waafaqsan Qaab-dhismeedka U hogaansama
1H NMR Spectrum Waafaqsan Qaab-dhismeedka U hogaansama
Gabagabo Alaabtu waa la tijaabiyay oo waafaqday tilmaamihii la bixiyay

Xidhmada/Kaydinta/Raridda:

Xidhmada:Dhalada fluorinated, bacda bireed aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Weelka si adag u xidh oo ku kaydi qabow, qalalan (2 ~ 8 ℃) iyo bakhaar hawo wanaagsan leh oo ka fog walxaha aan ku habboonayn.Ka ilaali iftiinka iyo qoyaanka.
Rarida:Ku gaarsii adduunka oo dhan hawo, by FedEx/DHL Express.Bixi keenid degdeg ah oo la isku halayn karo.

Habka Imtixaanka:

C10H17N3S·2HCl·H2O 302.26
(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino) benzothiazole dihydrochloride monohydrate [191217-81-9].
Qeexitaan
Pramipexole Dihydrochloride wuxuu ka kooban yahay NLT 98.0% iyo NMT 102.0% ee C10H19Cl2N3S, oo lagu xisaabiyo ku salaysan anhydrous.
AQOONSIGA
• A. Nuugista Infrared <197A> ama <197M>
Nambarka hirarka kala duwan: <197A>, 3800 cm-1 ilaa 650 cm-1;<197M>, 4000 cm-1 ilaa 600 cm-1
B. Waqtiga haynta ee ugu sarraysa ee xalka Tusaalaha waxay u dhigantaa tan pramipexole (S-enantiomer) ee xalka ku habboonaanta Nidaamka ee imtixaanka Enantiomeric Purity.
C. Tijaabada Aqoonsiga-Guud, Chloride <191>
Tusaalaha: 1 mg/ml ee Pramipexole Dihydrochloride ee biyaha
Shuruudaha aqbalaadda: Buuxiyay shuruudaha tijaabada nitrate-ka qalinka ah
ASSAY
Habka
Xalka A: Kala diri 9.1 g oo ah potassium dihydrogen phosphate iyo 5.0 g of sodium 1-octanesulfonate monohydrate 1 L oo biyo ah.Ku hagaaji phosphoric acid una beddel pH 3.0.
Xalka B: Acetonitrile iyo Xalka A (1:1)
Dareeraha: Acetonitrile iyo Xalka A (1:4)
Marxaladda guurguura: Eeg shaxda gradient ee hoose.
Waqtiga (min) Xalka A (%) Xalka B (%)
060 40
15 20 80
15.1 60 40
20 60 40
Xalka ku habboonaanta nidaamka: 1.5 mg/mL ee USP Pramipexole Dihydrochloride RS iyo 0.8 mg/mL ee USP Pramipexole Laxidhiidha Iskuxidhka A RS ee Diluent
Xalka caadiga ah: 1.5 mg/mL oo ah USP Pramipexole Dihydrochloride RS ee dareeraha
Xalka muunada: 1.5 mg/ml ee Pramipexole Dihydrochloride ee dareeraha ah
Nidaamka Chromatographic
(Fiiri Chromatography <621>, Habboonaanta Nidaamka.)
Habka: LC
Baaraha: UV 264 nm
Tiirka: 4.6-mm × 15-cm;5-µm xirmo L1
Heerkulka tiirka: 40 ± 5
Heerka socodka: 1.5 ml/min
Cabbirka duritaanka: 5µL
Ku habboonaanta nidaamka
Tusaalooyinka: Xalka ku habboonaanta nidaamka iyo xalalka caadiga ah [Xusuusin-Wakhtiyada sii haynta qaraabada ah ee isku xidhka pramipexole ee A iyo pramipexole waa qiyaastii 0.7 iyo 1.0, siday u kala horreeyaan.]
Shuruudaha ku habboonaanta
Xallinta: NLT 6.0 inta u dhaxaysa barxadda la xidhiidha pramipexole A iyo pramipexole, Xalka ku habboonaanta nidaamka
Qodobka dabada: NMT 2.0 ee pramipexole, nidaamka ku habboonaanta xalka
Isbeddelka heerka qaraabada: NMT 1.0%, Xalka caadiga ah
Falanqaynta
Tusaalooyinka: Xalka caadiga ah iyo xalalka muunada
Xisaabi boqolkiiba C10H19Cl2N3S ee qaybta Pramipexole Dihydrochloride ee la qaatay:
Natiijadu = (rU/rS) × (CS/CU) × (Mr1/Mr2) × 100
rU = jawaabta ugu sarreysa ee xalka Tusaalaha
rS = jawaabta ugu sarreysa ee xalalka caadiga ah
CS = fiirsashada USP Pramipexole Dihydrochloride RS ee xalka caadiga ah (mg/mL)
CU = fiirsashada saamiga saamiga (mg/mL)
Mr1 = Miisaanka molecular ee pramipexole dihydrochloride, 284.26
Mr2 = Miisaanka molecular ee pramipexole dihydrochloride monohydrate, 302.26
Shuruudaha aqbalaadda: 98.0%-102.0% ku salaysan anhydrous
XANUUNKA
wasakhda aan noolaha ahayn
• Hadhaaga dabka <281>: NMT 0.10%
• Biraha culus, Habka I <231>
Xalka caadiga ah: Xalka Lead ee caadiga ah, 10 ppm
Xalka Tusaalaha: Ash 2 g oo ah Pramipexole Dihydrochloride ilaa inta la helayo cuf kaarboonaysan oo ku dhow qalalan.Qabo hadhaaga, ku dar 2.0 ml oo nitric acid ah iyo 5 dhibcood oo sulfuric acid ah, si taxadar lehna u ogolow qiiqa inuu kobco.Shid 500-600 ilaa kaarboonku gabi ahaanba ka gubto.Qabooji haraaga, ku dar 4 mL oo ah 6 M hydrochloric acid, dabool qoloflaha, oo dheefshiidka qubeyska biyaha karkaraya 15 daqiiqo.Uumi u bixi qallayl.Ku dar hal dhibic oo ah hydrochloric acid iyo 10 ml oo biyo kulul ah, oo dheefshiido 2 daqiiqo oo kale qubeyska biyaha karkarinta.Ku dar 6 M xal ammonia hoos u dhac ilaa uu xalku daciif yahay alkaline, oo ku hagaaji 1 M acetic acid pH of 3.0-4.0.Ku sifee xalka 25-mL weel mug leh, oo ku mil biyo ilaa 25 mL adiga oo dhaqaya weelka iyo shaandhada.
Shuruudaha aqbalaadda: NMT 10 ppm
Waxyeellada dabiiciga ah
Habka
Xalka A, Xalka B, Diluent, Marxaladda Mobilka, iyo Nidaamka Chromatographic: U wad sida lagu faray Assay.
Xalka ku habboonaanta nidaamka: 7.5 µg/ml ee USP Pramipexole Dihydrochloride RS iyo 3 µg/mL ee USP Pramipexole Isku-xidhka Laxidhiidha A RS ee Diluent
Xalka caadiga ah: 1.5 µg/ml ee USP Pramipexole Dihydrochloride RS
Xalka muunada: 1.5 mg/ml ee Pramipexole Dihydrochloride ee dareeraha ah
Ku habboonaanta nidaamka
Tusaalooyinka: Xalka ku habboonaanta nidaamka iyo xalalka caadiga ah
Shuruudaha ku habboonaanta
Xallinta: NLT 6.0 inta u dhaxaysa barxadda la xidhiidha pramipexole A iyo pramipexole, Xalka ku habboonaanta nidaamka
Qodobka dabada: NMT 2.0 ee pramipexole, nidaamka ku habboonaanta xalka
Isbeddel heerka qaraabada ah: NMT 5.0%, Xalka caadiga ah
Falanqaynta
Tusaalooyinka: Xalka caadiga ah iyo xalalka muunada
Xisaabi boqolleyda wasakh kasta oo shakhsi ah ee qaybta Pramipexole Dihydrochloride ee la qaatay:
Natiijadu = (rU/rS) × (CS/CU) × (Mr1/Mr2) × 100
rU = jawaabta ugu sarreysa ee wasakh kasta oo ka timaadda xalka Tusaalaha
rS = jawaabta ugu sarreysa ee pramipexole oo ka timid xalalka caadiga ah
CS = fiirsashada USP Pramipexole Dihydrochloride RS ee xalka caadiga ah (mg/mL)
CU = fiirsashada pramipexole dihydrochloride monohydrate ee xalka Tusaalaha (mg/mL)
Mr1 = Miisaanka molecular ee pramipexole dihydrochloride, 284.26
Mr2 = Miisaanka molecular ee pramipexole dihydrochloride monohydrate, 302.26
Shuruudaha aqbalaadda
Wasakhda Shakhsiyeed: Eeg Shaxda 1aad ee wasakhda.
Wadarta wasakhda: NMT 0.5%
Shaxda wasakhaysan 1
Magaca Shuruudaha Ogolaanshaha Wakhtiga Haynta Qaraabo, NMT (%)
Pramipexole propionamidea 0.5 0.15
Xarunta Pramipexole ee la xidhiidha Ab 0.7 0.15
Pramipexole 1.0 —
N-Propylpramipexolec 1.4 0.15
Pramipexole dimerd 1.7 0.15
Mid kasta oo kale oo aan la aqoonsan shakhsi ahaan wasakhnimo - 0.10
a (S)-N-(2-Amino-4,5,6,7-tetrahydrobenzothiazol-6-yl)propionamide.
b (S)-4,5,6,7-Tetrahydrobenzothiazole-2,6-diamine.
c (S)-2,6-Dipropylamino-4,5,6,7-tetrahydrobenzothiazole.
d N6,N6'-[2-Methylpentane-1,3-diyl]bis(4,5,6,7-tetrahydrobenzothiazole-2,6-diamine).Kani waa dimer of pramipexole (isku dar ah afar isomers oo suurtagal ah).
IMTIXAANO GAAR AH
• Go'aaminta Biyaha, Habka I <921>: NLT 4.5% iyo NMT 6.5%
• Nadiifinta Enantiomeric
Marxaladda wareegta: n-Hexane, khamriga fuuqbaxay, iyo diethylamine (850:150:1)
Xalka saamiga ku habboonaanta nidaamka: 1 mg/mL midkiiba USP Pramipexole Dihydrochloride RS iyo USP Pramipexole Compound D RS ee khamriga fuuqbaxay
Xalka ku habboonaanta nidaamka: 0.01 mg/mL midkiiba USP Pramipexole Dihydrochloride RS iyo USP Pramipexole Combound D RS oo ka yimid nidaamka ku habboonaanta saamiga ee wejiga mobilada
Xalka saamiga caadiga ah: 2.0 mg/mL ee USP Pramipexole La Xiriira Isku-dhafka D RS ee khamriga fuuqbaxay
Xalka caadiga ah: 1.5 µg/ml ee USP Pramipexole La Xiriira Isku-dhafka D RS ee wajiga mobaylka
Tusaalaha xalalka: 0.3 mg/mL, oo ​​loo diyaariyey iyadoo lagu milmay tiro miisaaman oo ku habboon Pramipexole Dihydrochloride 25% ee mugga galaaska khamriga fuuqbaxay iyo lagu milo wejiga mobilada ilaa mugga.
Nidaamka Chromatographic
(Fiiri Chromatography 621, Habboonaanta Nidaamka.)
Habka: LC
Baaraha: UV 254 nm
Tiirka: 4.6-mm × 25-cm;10-µm xirmo L51
Heerka socodka: 1.5 ml/min
Cabbirka Tusaalaha: 75µL
Ku habboonaanta nidaamka
Tusaalooyinka: Xalka ku habboonaanta nidaamka [Fiiro gaar ah-Wakhtiyada haynta qaraabada ah ee isku xidhka pramipexole ee la xidhiidha D (R-enantiomer) iyo pramipexole (S-enantiomer) waa 0.5 iyo 1.0, siday u kala horreeyaan.]
Shuruudaha ku habboonaanta
Xallinta: NLT 5.0 inta u dhaxaysa xarunta pramipexole ee la xidhiidha D iyo pramipexole, Xalka ku habboonaanta nidaamka
Qodobka dabada: NMT 2.4 ee pramipexole, Nidaamka ku habboonaanta xalka
Falanqaynta
Tusaalooyinka: Xalka caadiga ah iyo xalalka muunada
Xisaabi boqolkiiba xarunta pramipexole ee D ee qaybta Pramipexole Dihydrochloride ee la qaatay:
Natiijadu = (rU/rS) × (CS/CU) × 100
rU = jawaabta ugu sarreysa ee xarunta pramipexole ee laxiriirta D ee xalka Tusaalaha
rS = jawaabta ugu sarreysa ee xarunta pramipexole ee laxiriirta D ee xalka caadiga ah
CS = fiirsashada xarunta pramipexole ee la xidhiidha D ee xalka caadiga ah (mg/mL)
CU = fiirsashada saamiga saamiga (mg/mL)
Shuruudaha aqbalaadda: NMT 1.0% ee isku dhafka pramipexole ee D
• Xadka Palladium
[Fiiro gaar ah- Samee tijaabadan haddii palladium ay tahay wasakh aan noolayn oo la yaqaan.]
Qalafsan: 0.1 M hydrochloric acid
Xalka caadiga ah: 40 µg/L ee palladium gudaha Diluent, laga bilaabo ganacsi ahaan la heli karo xalka palladium ee nuugista atomiga/balaasmaha isku xidhan[Xusuusin—Si cusub u diyaari xalkan sida loogu baahan yahay maalinta la isticmaalayo.]
Xalka Tusaalaha: Ilaa 0.5 g oo Pramipexole Dihydrochloride ah oo ku jira 50-mL caag mug leh ayaa ku dar 5.00 mL oo ah 1 M hydrochloric acid, oo ku milmi kulayl.Ku qabooji heerkulka qolka, oo ku mil biyo ilaa mugga.
Xaaladaha Spectrometric
(Fiiri Spectrophotometry iyo Iftiin-kala-firdhinta 851).
Qaabka: spectrophotometry nuugista atomiga
Dhererka mowjadda falanqaynta: Khadka qiiqa ee Palladium oo ah 247.6 nm
Lambaska: cathode madhan
Isha atomization: Foornada Graphite.[Xusuusin—Raac nidaamka soo saaraha ee taxanaha barnaamijka.]
Cabbirka Tusaalaha: 20µL
Banaan: Diluent
Ku habboonaanta nidaamka
Tusaale: Xalka caadiga ah
Shuruudaha ku habboonaanta
Nuugista: NLT 0.034
Falanqaynta
Tusaalooyinka: Xalka caadiga ah iyo xalalka muunada
Go'aami fiirsashada palladium ee xalka Tusaalaha habka isku-darka caadiga ah.
Shuruudaha aqbalaadda: NMT 5 ppm
SHURUUD DHEERAAD AH
Baakadaha iyo Kaydinta: Ku kaydi weelasha si fiican u xidhan, oo laga ilaaliyo qoyaanka iyo iftiinka.
• Heerarka Tixraaca USP 11
USP Pramipexole Dihydrochloride RS Guji si aad u aragto Qaabdhismeedka
Isku dhafka USP Pramipexole La Xiriira A RS
(S)-4,5,6,7-Tetrahydrobenzothiazole-2,6-diamine.
C7H11N3S 169.25
Isku dhafka USP Pramipexole ee la xidhiidha D RS
(R)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole.
C10H17N3S 211.33

Faa'iidooyinka:

Awood ku filan: Tas-hiilaad ku filan iyo farsamoyaqaanno

Adeegga Xirfadlaha: Adeegga iibsashada hal joogsi

Xidhmada OEM: Xidhmada gaarka ah iyo summada ayaa diyaar ah

Gaadhida Degdega ah: Haddii kaydku ku jiro, dammaanad bixinta saddex maalmood ah

Supply xasiloon: Hayso kayd macquul ah

Taageerada Farsamada: Xalka tignoolajiyada waa la heli karaa

Adeegga Isku-dhafka Gaarka ah: Wuxuu u dhexeeyaa garaam ilaa kiilo

Tayo Sare: Waxaa la sameeyay nidaam hubinta tayada dhamaystiran

FAQ:

Sidee loo Iibsadaa?Fadlan la xidhiidhDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

Khibrad 15 Sano ah?Waxaan leenahay in ka badan 15 sano oo waayo-aragnimo ah oo ku saabsan soo saarista iyo dhoofinta ee tiro balaadhan oo ah dhexdhexaad ah daawooyinka tayada sare leh ama kiimikooyinka ganaax.

Suuqyada Waaweyn?Iibiya suuqa gudaha, Waqooyiga Ameerika, Yurub, Hindiya, Kuuriya, Jabbaan, Australia, iwm.

Faa'iidooyinka?Tayada sare, qiimo jaban, adeegyo xirfadeed iyo taageero farsamo, gaarsiin degdeg ah.

TayadaHubinta?Nidaamka xakamaynta tayada adag.Qalabka xirfadlayaasha ah ee falanqaynta waxaa ka mid ah NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Imtixaanka xadka Microbial, iwm.

Tusaalooyinka?Badeecadaha intooda badani waxay bixiyaan muunado bilaash ah oo loogu talagalay qiimeynta tayada, kharashka dhoofinta waa in ay bixiyaan macaamiisha.

Hantidhawrka Warshada?Hantidhawrka warshada soo dhawoow.Fadlan horay u sii ballan.

MOQ?Ma jiro MOQ.Dalabka yar waa la aqbali karaa.

Waqtiga dirida? Haddii ay ku jirto kaydka, dammaanad bixinta saddex maalmood ah.

Gaadiidka?By Express (FedEx, DHL), hawada, badda.

Dukumentiyada?Adeegga iibka kadib: COA, MOA, ROS, MSDS, iwm waa la bixin karaa.

Isku-dhafka gaarka ah?Waxay ku siin kartaa adeegyada isku-dhafka gaarka ah si ay ugu habboonaato baahiyahaaga cilmi-baarista.

Shuruudaha Lacag-bixinta?Qaansheegga Proforma ayaa marka hore la soo diri doonaa ka dib marka la xaqiijiyo dalabka, oo lagu soo lifaaqay macluumaadka bangigayaga.Lacag bixinta T/T (Telex Transfer), PayPal, Western Union, iwm.

63-91-2-Macluumaadka Badbaadada:

H

Codsiga:

Pramipexole Dihydrochloride Monohydrate (CAS: 191217-81-9) ayaa la isticmaalaa

Halkan ku qor fariintaada oo noo soo dir