Vardenafil Dhexdhexaadiyaha CAS 224789-21-3 daahirnimo>99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. waa soo saaraha ugu horreeya ee 2- (2-Ethoxyphenyl) -5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4 (3H) -hal (CAS: 224789-21-3) oo leh tayo sare, dhexdhexaad ah Vardenafil.Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibka Vardenafil Dhexdhexaadiyeyaasha,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | 2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H) -hal |
| La mid ah | Vardenafil Dessulfonyl wasakh;2-(2-Ethoxyphenyl)-5-Methyl-7-Propyl-3H-Imidazo[5,1-F][1,2,4]triazin-4-hal;Vardenafil Propyl Imidazotriazinone wasakh;Isku dhafka Vardenafil 1 |
| Heerka Saamiyada | Kaydka dhexdiisa, Awood Wax-soo-saar 2 Tan bishii |
| Lambarka CAS | 224789-21-3 |
| Qaanuunka molecular | C17H20N4O2 |
| Miisaanka Molecular | 312.37 g/mol |
| Meesha dhalaalaysa | 142.0 ~ 148.0 ℃ |
| Cufnaanta | 1.26±0.10 g/cm3 |
| Kaydinta Muddada Dheer | Meel Qabow & Qallalan (2 ~ 8 ℃) |
| COA & MSDS | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Summada | Kiimikada Ruifu |
| Walxaha | Tilmaamaha | Natiijooyinka |
| Muuqashada | Ka-caddan ilaa budada jaalaha ah ee cirro leh | Budo-cad-cad |
| Meesha dhalaalaysa | 142.0 ~ 148.0 ℃ | 146.0 ~ 147.0 ℃ |
| Khasaare xagga qalajinta | <1.00% (102℃, 3h) | 0.23% |
| Biraha culus (Pb) | ≤20pm | <20ppm |
| Daahirnimada / Habka Falanqaynta | >99.0% (HPLC) | 99.79% |
| 1H NMR Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| Gabagabo | Alaabtu waa la tijaabiyay oo waafaqday tilmaamihii la bixiyay | |
| Codsiga | Dhexdhexaadiyaha Vardenafil / Vardenafil Hydrochloride | |
Xidhmada:Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Weelka si adag u xidh oo ku kaydi qabow, qalalan (2 ~ 8 ℃) iyo bakhaar hawo wanaagsan leh oo ka fog walxaha aan ku habboonayn.Ka ilaali iftiinka qorraxda iyo qoyaanka.
Rarida:Ku gaarsii adduunka oo dhan hawo, by FedEx/DHL Express.Bixi keenid degdeg ah oo la isku halayn karo.
1. Muuqashada: Ku rid muunada warqad cad oo u fiirso muuqaalka, cad-caddaan iyo budo jaale ah oo cirro leh.
2. Falanqaynta:
2.1 Go'aaminta barta dhalaalaysa sida sharciga qabo (Pharmacopoeia ee Shiinaha 2010 Daabacaadda II Lifaaqa ⅥC) Meesha dhalaalaysaa waa 142.0 ~ 148.0℃.
2.2 Khasaarida Qalajinta: Go'aaminta sida uu qabo sharciga (Lifaaqa ⅧL, Qaybta II, Daabacaadda 2010 ee Pharmacopoeia Shiinaha).Miisaanka saxda ah ee qiyaasta saxda ah ee alaabtan, qalalan 102 ℃ 3 saacadood, miisaan lumis waa in aanu ka badnayn 1.00%.
2.3 Biraha Culus: Go'aaminta sida uu qabo sharciga (Jamhuuriyadda Dadka ee Shiinaha Pharmacopoeia 2010 Edition, Qaybta II Lifaaqa ⅧH) Go'aaminta habka labaad.
Saxnaanta miisaankeedu yahay 1.0g ee alaabta tijaabada ah, si tartiib ah u gubanaya ilaa gebi ahaanba kaarboon, qabow, ku dar 0.5-1.0ml sulfuric acid, ka dhig qoyan, kulaylka heerkulka hooseeya ilaa sulfuric acid uu dhammeeyo, ku dar 0.5ml nitric acid, uumi qalalan, ilaa Uumiga nitrogen oxide waa daalan yahay, qabow, kulul at 500-600 ℃ si buuxda carbonized, qabow, ku dar 2ml hydrochloric acid, Ka dib markii lagu qalajiyo qubeyska biyaha, ku dar 15ml biyo ah, tuur xal tijaabada ammonia ilaa ay noqoto dhexdhexaad in tilmaame phenolphthalein xal, ku dar 2ml acetate buffer (ph3.5), oo in yar kulaylka milaan, u guuri tuubada Nachner colorimetric, oo ku qas 25ml biyo.Qaado reagent kale si aad u diyaariso xalka tijaabada, oo ku tumi saxan caag ah, ku dar 2ml acetate buffer (PH3.5) iyo 15ml biyo ah kulayl yar ka dib kala dirida Nath tuubada midabaynta, ku dar qadar go'an oo ah xalalka rasaasta caadiga ah, ka dibna ku qas biyo ilaa 25ml.Tijaabada midabaynta ayaa la sameeyaa inta u dhaxaysa xalka tijaabada iyo xalka caadiga ah si loo helo.Diyaarinta xalalka caadiga ah sida uu qabo (Jamhuuriyadda Dadka ee Shiinaha Pharmacopoeia 2010 daabacaadda II Lifaaqa Ⅷ Habka tijaabada biraha culus) habka ugu horreeya.Biraha culusi waa in aanay ka badnayn 20 qaybood halkii milyan.
3. Daahirnimada: Marka loo eego waxqabadka sare ee chromatography dareere ah, oo lagu go'aamiyay sharciga (Pharmacopoeia Shiinaha 2010 daabacaadda II Lifaaqa VD).
Xaaladaha Chromatographic:
Tiirka: C18, 200mm × 4.6mm, 5μm;
Marxaladda wareegta: Fosfate baffer (miisaanka 2.72g potassium dihydrogen phosphate, ku dar biyo si ay u milaan oo u milmaan 1000ml, hagaajin pH=3.5) : acetonitrile: = 35:65;
Dhererka hirarka: 254nm;
Heerka socodka: 1.0ml/min.
Habka go'aaminta: Qaado qiyaastii 30mg ee alaabtan, si sax ah u miisaamee, ku qas wajiga mobaylka si aad u samayso fiirsashada qiyaastii 0.3mg/ml, qaado 20μl chromatograph-ka dareeraha ah, duub chromatogramka.Marka loo eego habka caadiga ah ee aagga, nadiifnimadu kama yarayn 99.0%.
Sidee loo Iibsadaa?Fadlan la xidhiidhDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Khibrad 15 Sano ah?Waxaan leenahay in ka badan 15 sano oo waayo-aragnimo ah oo ku saabsan soo saarista iyo dhoofinta ee tiro balaadhan oo ah dhexdhexaad ah daawooyinka tayada sare leh ama kiimikooyinka ganaax.
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MOQ?Ma jiro MOQ.Dalabka yar waa la aqbali karaa.
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Dukumentiyada?Adeegga iibka kadib: COA, MOA, ROS, MSDS, iwm waa la bixin karaa.
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2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H) -hal (CAS: 224789-21-3) waa dhexdhexaad Vardenafil (CAS: 224785-90-4) / Vardenafil Hydrochloride (CAS: 224785-91-5).Vardenafil waa PDE5 inhibitor cusub oo loo bilaabay daaweynta afka ee cillad la'aanta ragga iyo waxay leedahay qaabdhismeed weyn oo la mid ah sildenafil (Viagra), kaas oo ahaa kii ugu horreeyay ee PDE5 ee lagu soo bandhigay 1998 tilmaantan.
Vardenafil wuxuu ahaa wakiilka labaad ee la suuq geeyey wuxuuna faa'iido u lahaa in waqtigiisa bilawga ah aan la dhimin iyadoo dawada lagu qaato calool buuxa .Waa 30 jeer ka awood badan sida horjoogaha PDE5 (macnaha IC50, 3.9 nM) marka loo eego sildenafil iyo 10 jeer ka awood badan tadalafil, oo leh doorasho weyn (> 1,000 jeer) ee PDE5 bini'aadamka marka loo eego PDE2, PDE3, iyo PDE4 iyo xulashada dhexdhexaadka ah (> 80 jeer) ee PDE1.Xulashada inhibitory PDE iyo labadaba in vitro iyo awoodda vivo ee PDE5 inhibitor vardenafil cusub.Vardenafil waxay si gaar ah u joojisay hydrolysis of cGMP by PDE5, oo leh IC50 ee 0.7 nM (sildenafil 6.6 nM).IC50 ee vardenafil ee PDE1 waxay ahayd 180 nM, PDE6 11 nM, iyo PDE2, PDE3 iyo PDE4 in ka badan 1,000 nM.
