Saldhig Lapatinib CAS 231277-92-2 Nadiifnimada

Saldhig Lapatinib CAS 231277-92-2 daahirnimo ≥99.0% (HPLC)

Sharaxaad Gaaban:

Magaca Kiimikada:Saldhig Lapatinib

CAS: 231277-92-2

Daahirsanaanta: ≥99.5% (HPLC)

Ku dhawaad Caddaan ama budo Jaalle ah oo khafiif ah

Xiriirka: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Alaabooyinka La Xiriira

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Lapatinib Intermediates:

Saldhig Lapatinib	CAS 231277-92-2
Lapatinib Ditosylate Monohydrate	CAS 388082-78-8
Sodium Methanesulfinate	CAS 20277-69-4
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2-Aminoethyl Methyl Sulfone Hydrochloride	CAS 104458-24-4
4-Chloro-6-Iodoquinazoline	CAS 98556-31-1
6-Iodo-4-Hydroxyquinazoline	CAS 16064-08-7
5-Formyl-2-Furanboronic Acid	CAS 27329-70-0
5-[4-[3-Chloro-4-(3-Fluorobenzyloxy)anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde	CAS 231278-84-5

Guryaha Kiimikada:

Magaca Kiimikada	Saldhig Lapatinib
La mid ah	Lapatinib;N-[3-Chloro-4-[(3-fluorobenzyl) oxy] phenyl]-6-[5-[[(2- (methylsulfonyl) ethyl]amino] methyl]furan-2-yl]quinazolin-4-amine ; N-[3-Chloro-4-[(3-fluorobenzyl) oxy] phenyl]-6-[5-[[2- (methylsulfonyl) ethyl]amino] methyl]-2-furyl]-4-quinazolinamine
Lambarka CAS	231277-92-2
Heerka Saamiyada	In Stock
Qaanuunka molecular	C29H26ClFN4O4S
Miisaanka Molecular	581.06
Meesha dhalaalaysa	141.0 ~ 149.0 ℃
Cufnaanta	1.381± 0.06 g/cm3
COA & MSDS	La heli karo
Summada	Kiimikada Ruifu

Tilmaamaha:

Shayga	Tilmaamaha
Muuqashada	Ku dhawaad Caddaan ama budo Jaalle ah oo khafiif ah
Aqoonsiga	IR;HPLC
Daahirnimada / Habka Falanqaynta	≥99.0% (HPLC)
Meesha dhalaalaysa	141.0 ~ 149.0 ℃
Khasaare xagga qalajinta	≤0.50%
Hadhaaga dabka	≤0.10%
Biraha culus (sida Pb)	≤20pm
Waxyaalaha wasakhaysan ee Dabiiciga ah	Buuxi Shuruudaha
Walxaha laxidhiidha
Xumaanta Keliya	≤0.30%
Wadarta wasakhda	≤1.00%
Heerka Imtixaanka	Heerka Ganacsiga
Nolosha shelf	2 Sano Marka Si Wanaagsan loo kaydiyo
Isticmaalka	API, Daawaynta Afka ee Kansarka Naasaha

Xidhmada & Kaydinta:

Xidhmada: Dhalo, bacda bireed aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka

Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka

Faa'iidooyinka:

FAQ:

231277-92-2 - Codsiga:

API (CAS: 231277-92-2)waa daawaynta la beegsanayo ee dawada kansarka naasaha, waa tyrosine kinase inhibitor, waxay si wax ku ool ah u joojin kartaa soo-dhoweynta koritaanka epidermal ee bini'aadamka -1 (ErbB1) iyo soo-dhoweynta korriinka koritaanka bini'aadamka (ErbB2) tyrosine kinase dhaqdhaqaaqa -2.Waa mid gaar ah in ay door ka ciyaari karto siyaabo kala duwan, si unugyada kansarka naasaha aysan u helin calaamadda loo baahan yahay koritaanka.Habka ficilku waa in la xakameeyo EGFR intracellular (ErbB-1) iyo HER2 (ErbB-2) goobaha ATP si looga hortago fosforyaalka iyo firfircoonida unugyada burooyinka, iyo in la xakameeyo hoos-u-dhigga calaamadaynta EGFR (ErbB-1) iyo HER2 (ErbB-1) isku-dhafan iyo laba wadarood oo kala duwan.Isku-darka (CAS: 231277-92-2) ee Capecitabine waxaa loo isticmaalaa in lagu daaweeyo bukaanada qaba kansarka naasaha ee sare ama metastatic oo leh xad-dhaaf ah oo ah reseptormal bini'aadamka2, oo horey loogu daaweeyay anthracyclines, paclitaxel, iyo trastuzumab.Tijaabooyin caafimaad ayaa muujiyay inay sidoo kale si wax ku ool ah u daaweyso bukaanka nooca kansarka ee HER2 leh iska caabin Herceptin.

231277-92-2 - Tilmaamaha:

Lapatinib oo lagu daray Capecitabine waxay ku habboon tahay daaweynta bukaannada kansarka naasaha ee horumarsan ama metastatic ee leh HER2 (ErbB-2 xad-dhaaf ah) iyo daaweyn hore oo ay ku jiraan anthracyclines, paclitaxel iyo trastuzumab.

231277-92-2 - Isdhexgalka daroogada:

Kiniinnada Lapatinib ee gudaha ku jira waxay ka joojin karaan CYP3A4 iyo CYP2C8 xajmiyada daawaynta, waxaana inta badan metaboleedyada CYP3A4.Daawooyinka joojiya hawshan enzyme waxay si weyn u kordhin kartaa xoogga daawada dhiigga ee Lapatinib.Ketoconazole, 0.2g mar kasta, 2 jeer/d, waxay kordhin kartaa AUC ee Lapatinib 3 ~ 7 jeer waxayna ku dheerayn kartaa nolosha nuska 1.7 jeer ka dib 7 maalmood.Mutadawiciin caafimaad qaba ayaa afka ka qaatay inducer CYP3A4, 100 mg mar kasta, laba jeer maalintii, waxayna u beddeleen 200mg mar kasta 3 maalmood ka dib, iyagoo wadaagaya 17 maalmood laba jeer maalintii.AUC ee Lapatinib ayaa hoos u dhacay 72%.Lapatinib waa goob lagu raro P-glycoprotein, iyo daawooyinka joojiya glycoprotein waxay kordhin karaan xoogga dhiiga daawada.

Daawooyinka Cusub ee Daawaynta La Beegsado ee Kansarka Naasaha:

Lapatinib waa daawo cusub oo loogu talagalay daawaynta la beegsaday ee kansarka naasaha oo ay samaysay GlaxoSmithKline, UK.Waa tyrosine kinase inhibitor kaas oo si wax ku ool ah u joojin kara soo-dhoweynta kobaca epidermal-ka bini'aadamka -1 (ErbB1) iyo kororka korriinka ee bini'aadamka -2 (ErbB2) waxqabadka tyrosine kinase.Waa mid gaar ah in ay siyaabo kala duwan u shaqeyn karto si unugyada kansarka naasaha aysan u helin calaamadaha loo baahan yahay koritaanka.Habka ficilku waa in la joojiyo goobaha ATP ee EGFR (ErbB-1) iyo HER2 (ErbB-2) ee unugyada si looga hortago fosfooraska iyo firfircoonida unugyada burooyinka, iyo xannibaadda calaamadaha hoos-u-dhigga iyada oo loo marayo isku-dhafka isku midka ah iyo kuwa kala duwan ee EGFR (ErbB) -1) iyo HER2 (ErbB-1).Daawaynta molecular ee kansarka naasaha waxaa loola jeedaa daawaynta oncogenes iyo alaabada hadalka la xidhiidha ee la xidhiidha dhacdada iyo horumarinta kansarka naasaha.Daawooyinka molecular bartilmaameedku waxay joojiyaan ama dilaan unugyada burooyinka iyagoo xannibaya gudbinta calaamadaha unugyada burooyinka ama unugyada la xidhiidha si loo xakameeyo isbeddelada muujinta hidda-wadaha unugyada.Bishii Maarso 14, 2007, maamulka cuntada iyo maandooriyaha Mareykanka ayaa ansixiyay isku darka lapatinib iyo xeloda (capecitabine) ee loogu talagalay daawaynta bukaannada kansarka naasaha ee horumarsan ama metastatic oo ay si xad dhaaf ah u caddeeyeen receptor factor factor 2 (ErbB2) oo lagu daaweeyay anthracyclines, paclitaxel iyo trastuzumab .Tijaabooyin caafimaad ayaa muujinaya in alaabtani ay sidoo kale saameyn caafimaad oo wanaagsan u leedahay bukaannada HER2 ee kansarka naasaha kuwaas oo yeeshay caabbinta daawada Roche's Herceptin (Herceptin).Lapatinib waa daawo cusub oo ka hortagga kansarka oo lala beegsaday.Waxay ku dhaqmi kartaa bartilmaameedyada Her-1 iyo Her-2 isku mar.Saamaynta bayooloji ee habkan ficilka ah ee fidinta iyo korriinka unugyada burooyinka ayaa aad uga weyn midka kaliya ee la beegsanayo.Waxa loogu yeero dawooyinka daawaynta ee la beegsaday waxay tixraacaan daawooyinka isticmaala qaar ka mid ah reseptors, hiddo-wadaha ama borotiinnada muhiimka ah sida bartilmaameedyada lagu dilo unugyada burooyinka ee la xidhiidha hab bartilmaameed ah.