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Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl) hydrazono] acetate Purity ≥99.0% (HPLC)
Kiimikada Ruifu waa alaab-qeybiyaha ugu horreeya ee Ethyl Chloro [(4-Methoxyphenyl) hydrazono] acetate (CAS: 27143-07-3) oo leh tayo sare, dhexdhexaad ah Apixaban (CAS: 503612-47-3).Ruifu waxa uu bixin karaa keenista aduunka oo dhan, qiimo tartan ah, tiro yar iyo tiro badan oo la heli karo.Iibso Apixaban dhexdhexaadiyeyaasha, iimaylka: alvin@ruifuchem.com
| Magaca Kiimikada | Ethyl Chloro[(4-Methoxyphenyl) hydrazono] acetate |
| La mid ah | Ethyl 2-Chloro-2-[2- (4-Methoxyphenyl) hydrazono] acetate;(Z)-Ethyl 2-Chloro-2- (2- (4-Methoxyphenyl) hydrazono) acetate;2-Chloro-2-[2- (4-Methoxyphenyl) hydrazinylidene];Apixaban-2;Apixaban wasakh 3 |
| Heerka Saamiyada | Suuqa dhexdiisa, Wax-soo-saarka Ganacsiga |
| Lambarka CAS | 27143-07-3 |
| Qaanuunka molecular | C11H13ClN2O3 |
| Miisaanka Molecular | 256.69 g/mol |
| Meesha dhalaalaysa | 94℃ |
| Cufnaanta | 1.23 |
| COA & MSDS | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Qaybta | Dhexe ee Apixaban (CAS: 503612-47-3) |
| Summada | Kiimikada Ruifu |
| Walxaha | Heerarka Kormeerka | Natiijooyinka |
| Muuqashada | Jaalle fudud ilaa budada jaalaha ah | U hogaansama |
| Khasaare xagga qalajinta | <0.50% | 0.23% |
| Daahirnimada / Habka Falanqaynta | ≥99.0% (HPLC) | 99.3% |
| Infrared Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| 1 H NMR Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| Gabagabo | Alaabta waa la tijaabiyay oo waafaqay tilmaamihii la bixiyay | |
Xidhmada:Dhalo, bacda bireed ee aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Weelka si adag u xidh oo ku kaydi qabow, qalalan (2 ~ 8 ℃) iyo bakhaar hawo wanaagsan leh oo ka fog walxaha aan ku habboonayn.Ka ilaali iftiinka iyo qoyaanka.
Rarida:Ku gaarsii adduunka oo dhan hawo, by FedEx/DHL Express.Bixi keenid degdeg ah oo la isku halayn karo.
Liiska xalalka loo isticmaalo wax soo saarka
| Maya | Magaca | CAS Maya. | Qaanuunka molecular |
| 1 | Ethyl acetate | CAS: 141-78-6 | C4H8O2 |
| 2 | Dichloromethane | CAS: 75-09-2 | CH2Cl2 |
| 3 | Khamriga Ethyl | CAS: 64-17-5 | C2H5OH |
5.3.1 Muuqashada: Waa in ay ahaataa huruud fudud ilaa budo huruud ah.Muuqaal ahaan, dhig tiro ku filan oo alaabta tijaabada ah (adigoon miisaan lahayn) saxan crystal nadiif ah oo ku yaal asalka cad (sida warqad cad) hoostiisa iftiinka dabiiciga ah.
5.3.2 Aqoonsiga: 1H-NMR wuxuu leeyahay qaab-dhismeed la mid ah kan caadiga ah.10 ~ 15mg ee muunada ayaa lagu miisaamay tuubada magnetic nukliyeerka, iyo 0.5mL of deuterium DMSO ayaa lagu daray si ay si buuxda u milaan muunadda, ka dibna lagu tijaabiyay qalab resonance nukliyeer ah oo ka badan 400MHz.
5.3.3 Khasaarida qalajinta: Miisaanka miisaanka 1.0g oo ku qalaji 3 saacadood foornada qalajinta ee 85 ℃.Qalliinka gaarka ah ee xisaabinta miisaan dhimista waa in la sameeyaa si waafaqsan shuruudaha SOP-AP-QC-002-01 ee Go'aaminta Dhimista Miisaanka Qalajinta.
5.3.4.1 Xaaladaha Chromatographic:
Tijaabada dib-u-hagaajinta: 1) acetonitrile ee chromatography 2) biyo nadiif ah 3) phosphoric acid
Tiirka: WondaCrac ODS-2 4.6*250mm*5um (8520-39993)
Marxaladda wareegta: A: Si sax ah u cabbir 1.0ml fosfooraska acid iyo 1000ml oo biyo ah, filter ultrasonic degassing.
B: Acetonitrile.
Habka gradient: shaxda soo socota
Waqtiga wareega wareega A (%) moobilka wajiga B (%)
3 90 10
10 25 75
20 0 100
25 0 100
Baaraha: 210nm
Heerkulka tiirka: 35 ℃
Xawaaraha socodka: 1.0ml/min
Cabbirka Tusaalaha: 5µl
5.3.4.2 Diyaarinta xalka:
5.3.4.3 dareere: acetonitrile
5.3.4.4 Xalka madhan: dareere waa in loo isticmaalaa xal maran.
5.3.4.5 Tijaabi xalinta badeecada: Miisaanka sheyga tijaabada ah oo ku saabsan 12.5mg ee dhalada mugga 25ml oo ku milan leh miisaan.
5.3.4.6 Habka hawlgalka: Ka dib markii saldhigga aasaasiga ah ee qalabku uu xasilloon yahay, hal ilaa laba irbadood oo xal faaruq ah ayaa horumarsan, ka dibna xalka badeecada tijaabada ayaa la falanqeynayaa.chromatogram-ka waa la keydiyay oo la falanqeeyay, meesha ugu sarreysa ee bannaan waa la jaray, iyo nadiifinta ugu sarreysa iyo natiijooyinka wasakhda ah ee chromatogram-ka ee badeecada waxaa lagu diiwaangeliyaa habka caadiga ah ee aagga.Falanqaynta ka dib, chromatogram-ka ayaa la daabacay.
Sidee loo Iibsadaa?Fadlan la xidhiidhDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Khibrad 15 Sano ah?Waxaan leenahay in ka badan 15 sano oo waayo-aragnimo ah oo ku saabsan soo saarista iyo dhoofinta ee tiro balaadhan oo ah dhexdhexaad ah daawooyinka tayada sare leh ama kiimikooyinka ganaax.
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TayadaHubinta?Nidaamka xakamaynta tayada adag.Qalabka xirfadlayaasha ah ee falanqaynta waxaa ka mid ah NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Imtixaanka xadka Microbial, iwm.
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MOQ?Ma jiro MOQ.Dalabka yar waa la aqbali karaa.
Waqtiga dirida? Haddii ay ku jirto kaydka, dammaanad bixinta saddex maalmood ah.
Gaadiidka?By Express (FedEx, DHL), hawada, badda.
Dukumentiyada?Adeegga iibka kadib: COA, MOA, ROS, MSDS, iwm waa la bixin karaa.
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Ethyl Chloro [(4-Methoxyphenyl) hydrazono] acetate (CAS: 27143-07-3) waxaa loo isticmaalaa dhexdhexaadinta isku dhafka Apixaban (CAS: 503612-47-3).Apixaban waa nooc cusub oo ah factor afka ah Xa inhibitor ay si wadajir ah u soo saareen Bristol-Myers Squibb iyo Pfizer.Magaca ganacsigu waa Erroto.Waa nooc cusub oo ah daawada xinjirowga lidka ku ah afka.Iyadoo la joojinayo xinjirowga muhiimka ah ee Xa, apixaban waxay ka hortagi kartaa soo saarista thrombin iyo xinjirowga dhiigga.Apixaban waxaa soo saartay Bristal-Myers squibb Company.Waxay leedahay bioavailability wanaagsan iyo xulashada sare.Waxaa lagu taxay Shiinaha 2013. Apixaban waa ammaan, suurtagalnimada isdhexgalka daroogada waa yar yahay, waxaana jira siyaabo badan oo lagu baabi'iyo, kaas oo la filayo in loo isticmaalo kooxo gaar ah oo qaba xanuunka beerka ama dhaawaca shaqada kelyaha.
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