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Ibrutinib Dhexdhexaad CAS 330792-70-6 daahirnimo>98.0% (HPLC) Sawirka
  • Ibrutinib Dhexdhexaad CAS 330792-70-6 daahirnimo>98.0% (HPLC)

Ibrutinib Dhexdhexaad CAS 330792-70-6 daahirnimo>98.0% (HPLC)

Sharaxaad Gaaban:

5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile

CAS: 330792-70-6

Daahirsanaanta:>98.0% (HPLC)

Muuqashada: Caddaan-ka-baxsan ilaa budada jaalaha ah ee fudud

Dhexdhexaadka Ibrutinib (CAS: 936563-96-1) 

Xiriirka: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Dhexdhexaadiyaha Ibrutinib:

Ibrutinib CAS 936563-96-1
3-Hydroxypiperidine CAS 6859-99-0
1-Boc-3-Hydroxypiperidine CAS 85275-45-2
(S)-1-Boc-3-Hydroxypiperidine CAS 143900-44-1
4-Phenoxybenzoic Acid CAS 2215-77-2
4-Phenoxyphenylboronic Acid CAS 51067-38-0
4-Aminopyrazolo[3,4-d] pyrimidine CAS 2380-63-4
4-Amino-3-Iodo-1H-Pyrazolo[3,4-d]pyrimidine CAS 151266-23-8
Ibrutinib Deacryloylpiperidine CAS 330786-24-8
5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile CAS 330792-70-6

Guryaha Kiimikada:

Magaca Kiimikada 5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile
La mid ah Ibrutinib Dhexdhexaadiyaha N-3;3-Amino-5- (4-Phenoxyphenyl) pyrazole-4-Carbonitrile;3-Amino-4-Cyano-5- (4-Phenoxyphenyl) pyrazole;5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile
Lambarka CAS 330792-70-6
Heerka Saamiyada Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan
Qaanuunka molecular C16H12N4O
Miisaanka Molecular 276.29
Cufnaanta 1.37±0.10 g/cm3
COA & MSDS La heli karo
Asal ahaan Shanghai, Shiinaha
Summada Kiimikada Ruifu

Tilmaamaha:

Shayga Tilmaamaha
Muuqashada Ka-bax-caddan ilaa budada jaalaha ah ee khafiifka ah
Daahirnimada / Habka Falanqaynta >98.0% (HPLC)
Khasaare xagga qalajinta <1.00%
Hadhaaga dabka <0.50%
Wadarta wasakhda <2.00%
Biraha culus (sida Pb) <20ppm
1 H NMR Spectrum Waafaqsan Qaab-dhismeedka
Heerka Imtixaanka Heerka Ganacsiga
Isticmaalka Dhexdhexaadka Ibrutinib (CAS: 936563-96-1)

Xidhmada & Kaydinta:

Xidhmada: Dhalo, bacda bireed ee aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka.

Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka.

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330792-70-6 - Codsiga:

5-Amino-3- (4-Phenoxyphenyl) -1H-Pyrazole-4-Carbonitrile (CAS: 330792-70-6) waa dhexe ee Ibrutinib (CAS: 936563-96-1).Ibrutinib waxay muujineysaa saameynta xannibaadda ee xoogga leh iyo kuwa aan la bedeli karin iyo xulashada waxqabadka enzymatic Btk.Dariiqa BCR ee firfircoon ee khadka unugyada DOHH2, Ibrutinib wuxuu joojiyaa autophosphorylation ee Btk, fosforyaalka Btk's substrate physiological PLCγ, iyo fosforyaalka kinase kale ee hoose, ERK oo leh IC50 ee 11 nM, 29 nM iyo 13 nM, siday u kala horreeyaan.Ibrutinib waxa uu soo bandhigaa qiyaas-ku-tiirsanaan iyo waqti-ku-tiirsanaan ku-tiirsanaanta cytotoxicity ee unugyada lymphocytic leukemia (CLL).Intaa waxaa dheer, Ibrutinib wuxuu keenaa dhimashada unugyada iyadoo ku xiran dhaqdhaqaaqa dariiqa caspase wuxuuna ka soo horjeedaa awoodda unugyada CLL si ay u bataan ka dib markii calaamadaha TLR.

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