CAS 361442-04-8 daahirnimo>99.0% (HPLC) API

Sharaxaad Gaaban:

La mid ah: BMS-477118;Onglyza

CAS: 361442-04-8

Daahirsanaanta:>99.0% (HPLC)

Muuqaalka: Budada Cad

API, Tayo Sare, Wax Soo Saarka Ganacsiga

E-Mail: alvin@ruifuchem.com

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Sharaxaad:

Dhexdhexaadiyayaasha La Xiriira Bixinta Kiimikada Ruifu
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Guryaha Kiimikada:

La mid ah	BMS-477118;Ongliza;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamantyl)acetyl]-2-Azabicyclo[3.1.0]hexane-3-Carbonitrile;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxytricyclo [3.3.1.13,7]dec-1-yl)acetyl]-2-Azabicyclo[3.1.0]hexane -3-Carbonitrile
Lambarka CAS	361442-04-8
Lambarka CAT	RF-PI1991
Heerka Saamiyada	Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan
Qaanuunka molecular	C18H25N3O2
Miisaanka Molecular	315.41
Summada	Kiimikada Ruifu

Tilmaamaha:

Shayga	Tilmaamaha
Muuqashada	Budada Cad
ur	Sifada
aqoonsiga	A: IR B: Waqtiga Haynta HPLC
Daahirnimada / Habka Falanqaynta	>99.0% (HPLC)
Cadaynta Xalka Biyaha	Daah-furnaan, Midab-la'aan, Arrimo la hakiyay midna ma jiro
Falanqaynta Sieve	100% Gudub 80 Mesh
Meesha dhalaalaysa	202.0 ~ 212.0 ℃
Khasaare xagga qalajinta	<0.50%
Sulfated Ash	<0.20%
Wareeg gaar ah	+174.0°~+186.0°
Xumaanta Keliya	<0.50%
Wadarta wasakhda	<1.00%
Biraha culus	<10pm
Arsenic (As)	<2.0pm
Ledhka (Pb)	<1.0pm
Cadmium (Cd)	<1.0pm
Xalalka Haraaga ah	<100pm
Hadhaaga sunta cayayaanka	xun
Microbiology
Wadarta tirada saxanada	<1000cfu/g
Khamiirka & Caaryada	<100cfu/g
E. Coli	xun
S. Aureus	xun
Salmonella	xun
Nolosha shelf	24 bilood laga bilaabo taariikhda wax soo saarka haddii si sax ah loo kaydiyo
Heerka Imtixaanka	Heerka Ganacsiga
Isticmaalka	API;Nooca 2aad ee Sonkorowga Mellitus

Xidhmada & Kaydinta:

Xidhmada: Dhalo, bacda bireed aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka

Xaaladda Kaydinta:Ku kaydi weelasha xiran meel qabow oo qallalan;Ka ilaali iftiinka iyo qoyaanka

Faa'iidooyinka:

FAQ:

Codsiga:

(BMS-477118) (CAS: 361442-04-8) waa mid awood leh, la dooran karo, dib loo celin karo, tartan iyo hadal firfircoon dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) horjooge.BMS-477118 waxay leedahay cilmi-baarista nooca 2 ee sonkorowga mellitus.BMS-477118waa dawada 2-aad ee xanuunka macaanka taasoo kicin karta xameetida inay soo saarto insuliin badan cuntada kadib.Waxaa lagu gaaray iskaashiga AstraZeneca iyo Bristol-Myers Squibb Company waxaana iska leh DPP-IV inhibitor.BMS-477118wuxuu door ka ciyaaraa isagoo joojinaya hoos u dhaca GLP-l.GLP-I waa hormoonnada si dabiici ah loogu soo saaro mindhicirka kadib qaadashada cuntada.Waxay nidaamin kartaa dheecaanka insulinta waxayna xoojisaa ka faa'iidaysiga gulukooska ee unugyada durugsan.Daawada kaliya ee BMS-477118 waxay wanaajin kartaa xakamaynta gulukooska dhiigga iyo dawada la isku daray ee BMS-477118 ee leh Metformin, Sulfonylurea iyo Thiazolidinediones waxay kor u qaadi kartaa saameynta daaweynta.Waxay u horseedaa khatarta hoose ee hypoglycemia iyo falcelinteeda xun waxay la mid tahay placebo, taasoo muujinaysa dulqaad wanaagsan.Bishii Luulyo 31, 2009, BMS-477118 Kiniinada (Onglyza), daawo cusub oo nooca 2-aad ee xanuunka macaanka, si wadajir ah loo baadhay oo loo sameeyay AstraZeneca iyo Bristol-Myers Squibb waxaa ansixiyay US FDA.Waxa la qaadan karaa hal mar maalintii si loo daweeyo nooca 2-aad ee xanuunka macaanka oo ay weheliso xakamaynta Cuntada iyo jimicsiga.