5- (2-Pyridyl) -1,2-Dihydropyridin-2-hal CAS 381233-78-9 Perampanel Nadiif Dhexdhexaad ah>98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. waa soo saaraha ugu horreeya ee 5- (2-Pyridyl) -1,2-Dihydropyridin-2-hal ([2,3'-Bipyridin] -6'(1'H) -hal (CAS: 381233-78-9) oo leh tayo sare, dhexdhexaad ah Perampanel (CAS: 380917-97-5).Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibka Perampanel dhexdhexaadiyaha,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | 5-(2-Pyridyl)-1,2-Dihydropyridin-2-hal |
| La mid ah | [2,3'-Bipyridin] -6'(1'H) -hal;5-(Pyridin-2-yl)pyridin-2(1H) -hal;5-(Pyridin-2-yl)-2(1H)-Pyridone;5-(2-Pyridyl)pyridin-2(1H) -hal;5-Pyridin-2-yl-1H-Pyridin-2-hal;5-(Pyridin-2-yl)-1,2-Dihydropyridin-2-hal;Perampanel wasakh 1 |
| Heerka Saamiyada | Suuqa dhexdiisa, Wax-soo-saarka Ganacsiga |
| Lambarka CAS | 381233-78-9 |
| Qaanuunka molecular | C10H8N2O |
| Miisaanka Molecular | 172.18 g/mol |
| Meesha dhalaalaysa | 71.0 ~ 75.0 ℃ |
| Cufnaanta | 1.221± 0.06 g/cm3 |
| COA & MSDS | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Qaybta | Dhexdhexaadiyaha Perampanel (CAS: 380917-97-5) |
| Nolosha shelf | 24 bilood haddii si habboon loo kaydiyo |
| Summada | Kiimikada Ruifu |
| Walxaha | Heerarka Kormeerka | Natiijooyinka |
| Muuqashada | Caddaan ilaa ku dhawaad cad budo | Budada Cad |
| Daahirnimada / Habka Falanqaynta | >98.0% (HPLC) | 99.7% |
| Biyaha waxaa qoray Karl Fischer | <1.00% | 0.58% |
| Xumaanta Keliya | <1.00% | U hogaansama |
| Wadarta wasakhda | <2.00% | 0.30% |
| 1H NMR Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| Gabagabo | Alaabtu waa la tijaabiyay oo waafaqday tilmaamihii la bixiyay | |
| Codsiga | Dhexdhexaadiyaha Perampanel (CAS: 380917-97-5) | |
Xidhmada:Dhalada fluorinated, bacda bireed aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
Xaaladda Kaydinta:Weelka si adag u xidh oo ku kaydi bakhaar qabow, engegan oo hawo wanaagsan leh oo ka fog walxaha aan ku habboonayn.Ka ilaali iftiinka iyo qoyaanka.
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Xalka: Tetrahydrofuran, Toluene, Ethylacetate, Ethanol, Methanol, tert-Butyl Methyl Ether, Petroleum Ether, n-Hexane, Dichloromethane
Hubi: Walxaha La Xidhiidha: Qaado alaabtan oo ku milmi dareere (wajiga wareega biyaha: methanol (50∶50)) si aad u samayso xal ka kooban 0.5mg 1mlkiiba sidii xalka alaabta tijaabada ah.Marka loo eego waxqabadka sare ee chromatography dareeraha (Pharmacopoeia ee Shiinaha 2010 Edition II Lifaaqa Ⅴ D), jelka silica (ZORBAX SB-C18 4.6 × 250mm,5m) ayaa loo adeegsaday buuxin ahaan.Marxaladda guurguura A waxay ahayd biyo, moobilka B wuxuu ahaa methanol, iyo hirarka la ogaaday wuxuu ahaa 254nm.Heerka socodka wuxuu ahaa 1.0ml/daqiiqo heerkulka tiirkana wuxuu ahaa heerkulka qolka.5μl ee xalka tijaabada ayaa si sax ah loo qiyaasay waxaana lagu duray chromatograph-ka dareeraha ah si loo duubo chromatogramka.Marka loo eego habka caadiga ah ee aagga, waxa ku jira badeecadani waa mid aan ka yarayn 98%.Haddii ay jiraan meelaha ugu sarreeya ee wasakhda ah ee chromatogram ee xalka alaabta tijaabada ah, aagga ugu sarreeya ee wasakhaysan waa inaanu ka badnayn 1.0%, iyo wadarta aagga ugu sarreeya ee wasakhaysan waa inaanu ka badnayn 2.0%.
Qoyaanka: Qaado alaabtan, isticmaal tijaabiyaha qoyaanka, marka loo eego habka Karl Fischer (Shiinaha Pharmacopoeia 2010 daabacaadda II Lifaaqa Ⅷ M habka koowaad A) go'aaminta, qoyaanka ku jira waa inuusan dhaafin 1.0%.
Sidee loo Iibsadaa?Fadlan la xidhiidhDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Khibrad 15 Sano ah?Waxaan leenahay in ka badan 15 sano oo waayo-aragnimo ah oo ku saabsan soo saarista iyo dhoofinta ee tiro balaadhan oo ah dhexdhexaad ah daawooyinka tayada sare leh ama kiimikooyinka ganaax.
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Dukumentiyada?Adeegga iibka kadib: COA, MOA, ROS, MSDS, iwm waa la bixin karaa.
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5-(2-Pyridyl)-1,2-Dihydropyridin-2-hal ([2,3'-Bipyridin] -6'(1'H) -hal) (CAS: 381233-78-9), dhexdhexaad ah Perampanel (CAS: 380917-97-5).Perampanel (shati la siiyay 2012) waa jiilka saddexaad ee AED oo loo yaqaan magaca sumadda leh ee Fycompa® (Eisai, Hatfield) ee UK iyo Banzel® (Eisai, Hatfield) ee Mareykanka.Daaweynta isku dhafka ah ee suuxdinta xudunta leh ama aan lahayn isugeynta sare iyo suuxdinta guud ee tonicclonic aasaasiga ah.Bishii Oktoobar 2012, US FDA waxay ansixisay perampanel daaweynta suuxdinta qayb ahaan bilawga ah ee bukaannada suuxdinta ee ugu yaraan 12 jir ah.Perampanel waa antagonistaha AMPA ee ugu horreeya si uu u helo oggolaanshaha FDA sida AED.Receptors AMPA glutamate ayaa ugu horreyn laga helaa neurons-ka postsynaptic ee maskaxda.Xulasho ahaan, iska soo horjeeda aan tartan lahayn ee AMPA, parampanel waxay ka hortagtaa furitaanka kanaalka ion waxayna yaraynaysaa faafinta kartida ficilka.
