4,4′-Bis(2-Bromoacetyl)biphenyl CAS 4072-67-7 Daclatasvir Dihydrochloride daahirnimo dhexdhexaad ah>98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. waa saaraha ugu horreeya ee 4,4'-Bis (2-Bromoacetyl) biphenyl (CAS: 4072-67-7) oo leh tayo sare leh.Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibka 4,4'-Bis(2-Bromoacetyl)biphenyl,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | 4,4'-Bis(2-Bromoacetyl)biphenyl |
| La mid ah | 4,4'-Bis (Bromoacetyl) biphenyl;1,1'-[1,1'-Biphenyl] -4,4'-diylbis[2-Bromoethan-1-hal];Daclatasvir wasakh 7 |
| Heerka Saamiyada | Suuqa dhexdiisa, Wax-soo-saarka Ganacsiga |
| Lambarka CAS | 4072-67-7 |
| Qaanuunka molecular | C16H12Br2O2 |
| Miisaanka Molecular | 396.07 g/mol |
| Meesha dhalaalaysa | 226.0 ~ 227.0 ℃ |
| Cufnaanta | 1.622± 0.06 g/cm3 |
| COA & MSDS | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Qaybta | Dhexdhexaadiyaha Daclatasvir Dihydrochloride (CAS: 1009119-65-6) |
| Summada | Kiimikada Ruifu |
| Walxaha | Tilmaamaha | Natiijooyinka |
| Muuqashada | Adag | Adag |
| Daahirnimada / Habka Falanqaynta | >98.0% (HPLC) | 98.5% |
| Infrared Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| 1H NMR Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| Gabagabo | Alaabtu waa la tijaabiyay oo waafaqday tilmaamihii la bixiyay | |
| Codsiga | Dhexdhexaadiyaha Daclatasvir Dihydrochloride (CAS: 1009119-65-6) | |
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4,4'-Bis(2-Bromoacetyl)biphenyl (CAS: 4072-67-7) waa dhex dhexaad u ah Daclatasvir Dihydrochloride (CAS: 1009119-65-6).
Daclatasvir Dihydrochloride (Daklinza) waa horjooge fayraska cagaarshow C (HCV) NS5A kaas oo faa'iido u leh daaweynta genotype 3 cagaarshow C dabadheeraad ah.
Bishii Luulyo 24, 2015, FDA waxay ogolaatay daawada cagaarshow C ee dabadheeraatay (Bristol-Myers Squibb) suuqgeyn.
Hannaanka ansixinta FDA ee Daklinza (Bristol-Myers Squibb) ayaa soo maray qallooc iyo leexleex.Waxaa mar diiday FDA, laakiin ugu dambeyntii la ansixiyay bartamihii 2015.FDA waxay ogolaatay isku darka Daklinza iyo Sofosbuvir ee daaweynta cagaarshowga nooca 3 ee bukaannada.
Dhab ahaantii, horraantii ka hor ansixinta FDA, Daklinza waxaa loo oggolaaday suuq-geynta Japan, Midowga Yurub iyo Koonfurta Kuuriya iyo dalal kale.2014, waaxda caafimaadka Japan waxay ogolaatay codsiga Daklinza iyo Asunaprevir (Sunvepra) ee daaweynta caabuqa genotype 1.Midowga Yurub ayaa sidoo kale ansixiyay Daclatasvir in lagu daro daawooyinka kale ee daaweynta HCV genotypes 1, 2, 3 iyo 4 ee 2014. Daclatasvir waa NS5A ugu horeysay inhibitor adag oo ay ansixiyeen Midowga Yurub (EU).Marka lagu daro dawooyinka kale, marka la barbar dhigo isku darka daaweynta interferon iyo ribavirin oo qaadata 48 toddobaad, waxay leedahay daweyn ka gaaban (12 toddobaad ama 24 toddobaad).
Daclathavir monotherapy laguma talinayo, borotokoolka caadiga ah ee hadda jira waa daaweynta isku dhafan ee Dacastavir + Sofosbuvir, taas oo lagu garto waxtarka wanaagsan, SVR sare, waxyeellooyin yar yar iyo wareeg daaweyn oo dheeraad ah oo gaaban oo ka duwan fursadaha kale.
