Apixaban Intermediate CAS 503615-03-0 3-Morpholino-1- (4-Nitrophenyl) -5,6-Dihydropyridin-2(1H) -hal daahir ≥99.0% (HPLC)
Ruifu Chemical waa soo saaraha ugu horreeya ee 3-Morpholino-1- (4-Nitrophenyl) -5,6-Dihydropyridin-2 (1H) -hal (CAS: 503615-03-0) oo leh tayo sare.Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibso Apixaban dhexdhexaadiyeyaasha,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | 3-Morpholino-1-(4-Nitrophenyl)-5,6-Dihydropyridin-2(1H) -hal |
| La mid ah | 3- (4-Morpholinyl) -1- (4-Nitrophenyl) -5,6-Dihydro-2 (1H) -Pyridinone;5,6-Dihydro-3- (4-Morpholinyl) -1- (4-Nitrophenyl) -2 (1H) - Pyridinone;Apixaban Intermediate 3;Apixaban Impurity 36;Habka Apixaban wasakhda 1 |
| Heerka Saamiyada | Suuqa dhexdiisa, Wax-soo-saarka Ganacsiga |
| Lambarka CAS | 503615-03-0 |
| Qaanuunka molecular | C15H17N3O4 |
| Miisaanka Molecular | 303.31 g/mol |
| Meesha dhalaalaysa | 165.0 ~ 170.0 ℃ |
| Barta Karsan | 506.5 ± 50.0 ℃ |
| Cufnaanta | 1.357g/ml |
| COA & MSDS | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Qaybta | Dhexe ee Apixaban (CAS: 503612-47-3) |
| Summada | Kiimikada Ruifu |
| Walxaha | Heerarka Kormeerka | Natiijooyinka |
| Muuqashada | Budada jaalaha ah | Budada jaalaha ah |
| Meesha dhalaalaysa | 165.0 ~ 170.0 ℃ | 167.0 ~ 170.0 ℃ |
| Khasaare xagga qalajinta | ≤0.50% | 0.3% |
| Xumaanta Shakhsi ahaaneed (Max.) | ≤0.50% | 0.3% |
| Wadarta wasakhda | ≤1.00% | 0.6% |
| Daahirnimada / Habka Falanqaynta | ≥99.0% (HPLC) | 99.4% |
| 1 H NMR Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| LC/MS | Waafaqsan Qaab-dhismeedka | U hogaansama |
| Gabagabo | Alaabta waa la tijaabiyay oo waafaqay tilmaamihii la bixiyay | |
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Xaaladda Kaydinta:Weelka si adag u xidh oo ku kaydi qabow, qalalan (2 ~ 8 ℃) iyo bakhaar hawo wanaagsan leh oo ka fog walxaha aan ku habboonayn.Ka ilaali iftiinka iyo qoyaanka.
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Dukumentiyada?Adeegga iibka kadib: COA, MOA, ROS, MSDS, iwm waa la bixin karaa.
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3-Morpholino-1- (4-Nitrophenyl) -5,6-Dihydropyridin-2 (1H) -hal (CAS: 503615-03-0) waa dhexdhexaadinta isku dhafka Apixaban (CAS: 503612-47-3) .
Apixaban waa nooc cusub oo ah Xa-xakameeyaha afka laga qaato oo ay si wadajir ah u soo saareen Bristol-Myers Squibb iyo Pfizer.Magaca ganacsiga waa Eratol, oo ah nooc cusub oo ah daawada xinjirowga lidka ku ah afka.Iyadoo la xakameynayo xinjirowga muhiimka ah ee Xa, Apixaban waxay ka hortagi kartaa soosaarka thrombin iyo xinjirowga dhiigga.
Bishii Abriil 26, 2007, Bristol-Myers Squibb waxay ku biirtay gacmaha Pfizer si ay ugu dhawaaqdo iskaashiga horumarinta daawada xinjirowga lidka ku ah afka ee cusub ee Apixaban oo ay leedahay Bristol-Myers Squibb oo ah beddelka warfarin oo la cusboonaysiiyay.Sida ku cad heshiiska iskaashiga, Pfizer waxay bixin doontaa lacag horudhac ah oo US $ 0.25 bilyan ah Bristol-Myers Squibb si ay u qaadato 60% wadarta kharashka horumarinta daawada xinjirowga lidka ku ah ee Apixaban (laga bilaabo Janaayo 1, 2007), halka Bristol-Myers Squibb wuxuu qaadi doonaa inta soo hartay 40%, si uu u helo xuquuqda wadajirka ah ee horumarinta iyo iibinta daawada.
Bishii Maajo 2011, Apixaban wuxuu ahaa kii ugu horreeyay ee oggolaaday ka hortagga xinjirowga dhiigga ee bukaannada qaangaarka ah ee ku socda qalliinka beddelka miskaha ama jilibka ee la doortay ee 27 dalalka EU, Iceland iyo Norway.
Noofambar 20, 2012, Komishanka Yurub ayaa ansixiyay Ererto (Apixaban) si looga hortago istaroogga iyo embolism-ka habdhiska bukaanka ee bukaannada qaangaarka ah ee qaba fibrillation aan valvular ahayn (NVAF) oo leh hal ama dhowr arrimood oo halis ah.Ka dib, Maamulka Cuntada iyo Dawooyinka ee Kanadiyaanka, Japan, iyo US FDA waxay ansixiyeen Ererto (Apixaban) ka hortagga istaroogga iyo embolism-ka nidaamka ee bukaannada qaangaarka ah ee qaba fibrillation aan valvular ahayn (NVAF) oo leh hal ama dhowr arrimood oo halis ah.
Abriil 12, 2013, dawada cusub ee xinjirowga lidka ku ah ee Eloto (ELIQUIS)(apixaban) oo ay si wadajir ah u sameeyeen Bristol-Myers Squibb iyo Pfizer ayaa si rasmi ah loogu dhawaaqay in lagu taxay Shiinaha.Ererto waa cunsur cusub oo afka laga qaato Xa inhibitor oo loogu talagalay ka hortagga xinjirowga dhiigga xididada (VTE) ee bukaannada qaangaarka ah ee lagu beddelayo sinta ama jilibka ee la doortay.Liiskeedu wuxuu bixiyaa doorasho cusub oo badbaado leh oo waxtar leh oo loogu talagalay xinjirowga lidka ku ah bukaan-socodka ka dib qalliinka lafaha, waxayna u keentaa war wanaagsan bukaannada Shiinaha ee maraya beddelka miskaha/jilibka.Daraasadaha caafimaadku waxay xaqiijiyeen in marka la barbar dhigo 40mg enoxaparin hal mar maalintii, 2 jeer maalintii maamulka afka ee Eratol (Apixaban) 2.5mg ayaa aad waxtar ugu leh ka hortagga xinjirowga xididdada xididdada dhiigga ka dib qalliinka beddelka sinta ama jilibka, mana kordhinayso khatarta dhiig-baxa.
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