Apixaban Dhexdhexaad CAS 545445-44-1 daahirnimo>98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. waa soo saaraha ugu horreeya ee 3-Morpholino-1- (4- (2-Oxopiperidin-1-yl) phenyl) -5,6-Dihydropyridin-2 (1H) -hal (CAS: 545445). -44-1) oo leh tayo sare, dhexdhexaad ah Apixaban (CAS: 503612-47-3).Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibso Apixaban Intermediates,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | 3-Morpholino-1-(4- (2-Oxopiperidin-1-yl) phenyl)-5,6-Dihydropyridin-2(1H) -hal |
| La mid ah | Apixaban Intermediate 1;5,6-Dihydro-3- (4-Morpholinyl) -1- [4- (2-Oxo-1-Piperidinyl) phenyl] -2 (1H) - Pyridinone;5-Morpholin-4-yl-1-[4- (2-Oxopiperidin-1-yl) phenyl] -2,3-Dihydropyridin-6-hal;Apixaban Impurity A |
| Heerka Saamiyada | Suuqa dhexdiisa, Wax-soo-saarka Ganacsiga |
| Lambarka CAS | 545445-44-1 |
| Qaanuunka molecular | C20H25N3O3 |
| Miisaanka Molecular | 355.43 g/mol |
| Meesha dhalaalaysa | >199 ℃(dac.) |
| Cufnaanta | 1.267 g/ml |
| COA & MSDS | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Qaybta | Dhexe ee Apixaban (CAS: 503612-47-3) |
| Summada | Kiimikada Ruifu |
| Walxaha | Tilmaamaha | Natiijooyinka |
| Muuqashada | Budada Jaallaha fudud | Budada Jaallaha fudud |
| Khasaare xagga qalajinta | <0.50% | 0.16% |
| Hadhaaga dabka | <0.20% | 0.07% |
| Daahirnimada / Habka Falanqaynta | >98.0% (HPLC Aagga) | 99.12% |
| Xumaan Shaqsiyeed Kasta | <0.50% | <0.50% |
| Wadarta wasakhda | <2.00% | 0.88% |
| 1H NMR Spectrum | Waafaqsan Qaab-dhismeedka | waafaqsan |
| LC-MS ee Aqoonsiga | waafaqsan | waafaqsan |
| Gabagabo | Alaabtu waa la tijaabiyay oo waafaqday tilmaamihii la bixiyay | |
| Codsiga | Dhexe ee Apixaban (CAS: 503612-47-3) | |
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3-Morpholino-1- (4- (2-Oxopiperidin-1-yl) phenyl) -5,6-Dihydropyridin-2 (1H) -hal (CAS: 545445-44-1) waa dhexdhexaad ah Apixaban (CAS: 503612-47-3).
Apixaban waa nooc cusub oo ah Xa-xakameeyaha afka laga qaato oo ay si wadajir ah u soo saareen Bristol-Myers Squibb iyo Pfizer.Magaca ganacsiga waa Eratol, oo ah nooc cusub oo ah daawada xinjirowga lidka ku ah afka.Iyadoo la xakameynayo xinjirowga muhiimka ah ee Xa, Apixaban waxay ka hortagi kartaa soosaarka thrombin iyo xinjirowga dhiigga.Bishii Abriil 26, 2007, Bristol-Myers Squibb waxay ku biirtay gacmaha Pfizer si ay ugu dhawaaqdo iskaashiga horumarinta daaweeyaha xinjirowga lidka ku ah afka ee cusub ee Apixaban oo ay leedahay Bristol-Myers Squibb oo ah beddelka la cusboonaysiiyay ee Warfarin.Bishii Maajo 2011, Apixaban wuxuu ahaa kii ugu horreeyay ee oggolaaday ka hortagga xinjirowga dhiigga ee bukaannada qaangaarka ah ee ku socda qalliinka beddelka miskaha ama jilibka ee la doortay ee 27 dalalka EU, Iceland iyo Norway.Noofambar 20, 2012, Komishanka Yurub ayaa ansixiyay Ererto (Apixaban) si looga hortago istaroogga iyo embolism-ka habdhiska bukaanka ee bukaannada qaangaarka ah ee qaba fibrillation aan valvular ahayn (NVAF) oo leh hal ama dhowr arrimood oo halis ah.Ka dib, Maamulka Cuntada iyo Dawooyinka ee Kanadiyaanka, Japan, iyo US FDA waxay ansixiyeen Ererto (Apixaban) ka hortagga istaroogga iyo embolism-ka nidaamka ee bukaannada qaangaarka ah ee qaba fibrillation aan valvular ahayn (NVAF) oo leh hal ama dhowr arrimood oo halis ah.Abriil 12, 2013, dawada cusub ee xinjirowga lidka ku ah ee Eloto (ELIQUIS) (Apixaban) oo ay si wadajir ah u sameeyeen Bristol-Myers Squibb iyo Pfizer ayaa si rasmi ah loogu dhawaaqay in lagu taxay Shiinaha.
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