5-Amino-3-(Trifluoromethyl) picolinonitrile CAS 573762-62-6 Apalutamide Nadiifinta Dhexdhexaadka ah>98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. waa soo saaraha ugu horreeya ee 5-Amino-3- (Trifluoromethyl) picolinonitrile (CAS: 573762-62-6) oo leh tayo sare leh, dhexdhexaad ah Apalutamide (CAS: 956104-40-8).Kiimikada Ruifu waxay bixin kartaa gaarsiinta adduunka oo dhan, qiimo tartan ah, adeeg aad u wanaagsan, tiro yar iyo tiro badan oo la heli karo.Iibso dhexdhexaadiyaha Apalutamide,Please contact: alvin@ruifuchem.com
| Magaca Kiimikada | 5-Amino-3-(Trifluoromethyl) picolinonitrile |
| La mid ah | 5-Amino-3-(Trifluoromethyl) pyridine-2-Carbonitrile;5-Amino-3-(Trifluoromethyl) 2-Cyanopyridine;5-Amino-2-Cyano-3-(Trifluoromethyl) pyridine;Apalutamide wasakhnimada 10 |
| Heerka Saamiyada | Suuqa dhexdiisa, Wax-soo-saarka Ganacsiga |
| Lambarka CAS | 573762-62-6 |
| Qaanuunka molecular | C7H4F3N3 |
| Miisaanka Molecular | 187.12 g/mol |
| Cufnaanta | 1.45±0.10 g/cm3 |
| COA & MSDS | La heli karo |
| Asal ahaan | Shanghai, Shiinaha |
| Heerka khatarta | 6.1 |
| Kooxda Baakadaha | Ⅲ |
| Qaybta | Dhexdhexaadiyaha Apalutamide (CAS: 956104-40-8) |
| Summada | Kiimikada Ruifu |
| Walxaha | Heerarka Kormeerka | Natiijooyinka |
| Muuqashada | Jaalle fudud ilaa huruud adag | U hogaansama |
| Biyaha waxaa qoray Karl Fischer | <0.50% | 0.35% |
| Daahirnimada / Habka Falanqaynta | >98.0% (HPLC) | 99.03% |
| Infrared Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| 1H NMR Spectrum | Waafaqsan Qaab-dhismeedka | U hogaansama |
| Gabagabo | Alaabtu waa la tijaabiyay oo waafaqday tilmaamihii la bixiyay | |
| Codsiga | Dhexdhexaadiyaha Apalutamide (CAS: 956104-40-8) | |
Xidhmada:Dhalada fluorinated, bacda bireed aluminium, 25kg/Drum kartoonada, ama sida waafaqsan shuruudaha macmiilka.
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5-Amino-3- (Trifluoromethyl) picolinonitrile (CAS: 573762-62-6), waa pyridine heterocyclic organic compound, kaas oo loo isticmaali karo dhexdhexaadinta daawada.5-Amino-3-(Trifluoromethyl) picolinonitrile waa dhexdhexaadiye Apalutamide (CAS: 956104-40-8).Apalutamide waa antiandrogen-jiilka labaad ee loo isticmaalo daawaynta kansarka qanjirka 'prostate'.Waa antagonist awood leh oo soo dhaweeye androgen ah oo leh IC50 qiimaha 16 nM.Waxay xidhaa reseptors androgen, taas oo ka hortagaysa isu-beddelka nukliyeerka, ku-xidhka DNA-ga iyo firfircoonida qoraalka.Apalutamide waxay leedahay codsiyo daweyn oo aan ahayn dheef-shiid kiimikaad, kansarka qanjirka 'prostate'.
Apalutamide waxaa loo isticmaalaa in lagu daaweeyo noocyo ka mid ah kansarka qanjirka 'prostate' u adkeysta castration ama kansarka qanjirka 'prostate' ee aan ku faafin qaybaha kale ee jirka, laakiin aan lagu caawin daawaynta kale.Apalutamide waxay ku jirtaa nooc dawooyin ah oo la yiraahdo androgen receptor inhibitors.Waxay u shaqeysaa iyadoo xannibaysa saameynta androgen si ay u joojiso koritaanka iyo fiditaanka unugyada kansarka.Sebtembar 17, 2019, Maamulka Cuntada iyo Dawooyinka ayaa ansixiyay Apalutamide (ERLEADA, Janssen Biotech, Inc) bukaannada qaba kansarka qanjirka 'prostate' ee xasaasiga ah (mCSPC).Apalutamide waxaa markii hore loo oggolaaday 2018 bukaannada qaba kansarka qanjirka 'prostate' ee aan metastatic ahayn.
