TMC207 CAS 843663-66-1 daahirnimo>99.5% (HPLC)
Dhexdhexaadiyeyaasha la xidhiidha TMC207:
TMC207 CAS 843663-66-1
3-Benzyl-6-Bromo-2-Chloroquinoline CAS 654655-68-2
3-Benzyl-6-Bromo-2-Methoxyquinoline CAS 654655-69-3
| Magaca Kiimikada | TMC207 |
| La mid ah | TMC-207, R207910;Sirturo;(αS, βR) -6-Bromo-α- [2- (dimethylamino) ethyl] -2-methoxy-α-1-naphthalenyl-β-phenyl-3-Quinolineethanol;1- (6-Bromo-2-methoxyquinolin-3-yl) -4-dimethylamino-1-phenyl-2- (1-naphthyl) 2-butanol |
| Lambarka CAS | 843663-66-1 |
| Lambarka CAT | RF2336 |
| Heerka Saamiyada | Kaydka dhexdiisa, Qiyaasta Waxsoosaarka Ilaa Tan |
| Qaanuunka molecular | C32H31BrN2O2 |
| Miisaanka Molecular | 555.516 |
| Meesha dhalaalaysa | 104℃ |
| Cufnaanta | 1.322± 0.06 g/cm3 |
| Xasaasi ah | HygroscopicXasaasi Fudud, Dareen Hawada |
| Summada | Kiimikada Ruifu |
| Shayga | Tilmaamaha |
| Muuqashada | Budada cad ama Off-Cad |
| Daahirnimada / Habka Falanqaynta | > 99.5% (HPLC) |
| Khasaare xagga qalajinta | <0.50% |
| Hadhaaga dabka | <0.20% |
| Xumaan Shaqsiyeed Kasta | <0.10% |
| Isomer | <0.10% |
| Wadarta wasakhda | <0.50% |
| Biraha culus (sida Pb) | <20ppm |
| Arsenic (As) | <2.0pm |
| Infrared Spectrum | Waafaqsan Qaab-dhismeedka |
| Proton NMR Spectrum | Waafaqsan Qaab-dhismeedka |
| Heerka Imtixaanka | Heerka Ganacsiga |
| Isticmaalka | API |
Xidhmada: Dhalo, bacda bireed aluminium, 25kg / Durbaan kartoonada, ama sida waafaqsan shuruudaha macmiilka
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(CAS: 843663-66-1), (oo loo yaqaan TMC207 iyo R207910), oo lagu iibiyo magaca ganacsiga Sirturo, waa dawada diarylquinoline ee antimycobacterial novel taas oo saamaysa tiibishada iyadoo la joojinayo dhaqdhaqaaqa M. qaaxada ATP synthase proton pump.Isku-darka ATP ee mycobacteria wuxuu leeyahay saameyn bakteeriyada iyo bakteeriyada.Si kiliinig ah ayaa loo isticmaalaa in lagu daweeyo qaaxada dadka waaweyn ee u adkeysata daawooyinka badan (MDR-PTB).TMC207 waxay leedahay hawl bakteeriyad isku mid ah oo ka dhan ah M. qaaxada nuucyada xasaasiga ah iyo noocyada adkaysiga leh, sidoo kale waxay leedahay saamayn nadiifin wanaagsan oo bakteeriyada hurda.Bishii Disembar 2012, US FDA waxay ansixisay TMC207 oo qayb ka ah daawaynta isku dhafka ah ee daawaynta tiibishada u adkaysata daawooyinka badan (MDRTB).TMC207 waa daawadii ugu horeysay ee loo ogolaado MDR-TB waana ogolaanshihii ugu horeeyay ee fasalka cusub ee wakiilada ka hortagga qaaxada 40kii sano ee la soo dhaafay.Baahida caafimaad ee sare ee daawaynta MDR-TB awgeed, FDA waxay siisay TMC207 ogolaansho la dadajiyay oo ku salaysan natiijooyinka Wajiga II, taasoo siinaysa bukaanada marin u helka daawada iyadoo daraasado caafimaad oo dheeri ah la sameynayo.TMC207 waa diarylquinoline oo laga helay istaraatijiyad baadhiseed heersare ah oo unug dhan ah oo leh Mycobacterium smegmatis oo loo isticmaalo beddelka M. qaaxada.TMC207 waa hal-abuure hal-abuure ah oo ku dhacay baadhista bilowga ah.TMC207 waxay leedahay hawlo awood leh oo door ah oo ka dhan ah mycobacteria, waxayna si firfircoon uga hortagtaa daawooyinka xasaasiga ah iyo kuwa u adkaysta daawooyinka M. qaaxada.Habka ficilka ee TMC207 waa mid gaar ah oo ka mid ah daawooyinka ka hortagga TB-da waxayna ku lug leedahay joojinta mycobacterial ATP synthase;ma aha mid firfircoon oo liddi ku ah bini'aadamka ATP synthase.TMC207 waxay ku leedahay firfircoonida vivo noocyo badan oo hore u ah infekshanka TB, kaligiis iyo marka lagu daro wakiilada kale ee ka hortagga tiibayda, waxayna leedahay hawlo bakteeriyayaal ah moodooyinka caabuqa qaaxada ee la aasaasay.TMC207 waxa lagu farsameeyay shan tilaabo laga soo bilaabo 3-Phenylpropionic Acid iyo para-Bromoaniline.Ka dib samaynta amide, daawaynta POCl3 iyo DMF ee hoos timaada shuruudaha Vilsmeier-Hack waxay siisay badeecad 2-Chloroquinoline ah.Daawaynta sodium methoxide, oo ay ku xigto uumi 3- (Dimethylamino) -1- (naphthalen-1-yl) propan-1-one, iyo kala-soocida isomers waxay siisay TMC207.
